Abstract: An automated carrier system is disclosed for moving objects to be processed. The automated carrier system includes a discontinuous plurality of track sections on which an automated carrier may be directed to move, and the automated carrier includes a base structure on which an object may be supported, and at least two wheels assemblies being pivotally supported on the base structure for pivoting movement from a first position to a second position to effect a change in direction of movement of the carrier.

Abstract: A programmable motion system is disclosed that includes a dynamic end effector system. The dynamic end effector system includes an end effector that is coupled via a dynamic coupling to the programmable motion system, wherein the dynamic coupling provides that at least a portion of the end effector may spin with respect to an other portion of the end effector.

Abstract: A system is disclosed for providing high flow vacuum control to an end effector of an articulated arm. The system includes a high flow vacuum source that provides an opening with an area of high flow vacuum at the end effector such that objects may be engaged while permitting substantial flow of air through the opening, and a load detection system for characterizing the load presented by the object.

Abstract: An object processing system within a trailer for a tracker trailer is discloses. The object processing system includes an input area of the trailer at which objects to be processed may be presented, a perception system for providing perception data regarding objects to be processed, and a primary transport system for providing transport of each object in one of at least two primary transport directions within the trailer based on the perception data.

Abstract: An online concierge system iteratively makes a batch of one or more orders available to an increasing number of shoppers to choose to fulfill. Each shopper may choose to accept or reject a batch for fulfillment. To improve batch acceptance and matching between batches and shoppers, the batches are scored with respect to expected resource costs, likelihood of acceptance by the shopper, and/or other quality metrics to iteratively offer the batch to an increasing number of shoppers (prioritizing the scoring factors) until a shopper accepts. The number of shoppers notified of the batch and the frequency that additional shoppers are selected may vary based on characteristics of the batch and likelihood the batch will be accepted by a shopper.

Abstract: A storage, retrieval and processing system for processing objects is disclosed. The storage, retrieval and processing system includes a plurality of storage bins providing storage of a plurality of objects, where the plurality of storage bins is in communication with a retrieval conveyance system, a programmable motion device in communication with the retrieval conveyance system for receiving the storage bins from the plurality of bins, where the programmable motion device includes an end effector for grasping and moving a selected object out of a selected storage bin, and a movable carriage for receiving the selected object from the end effector of the programmable motion device, and for carrying the selected object to one of a plurality of destination bins.

Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

Abstract: The online concierge system generates task units based on orders and assigns batches of task units to pickers. The online concierge system generates task units based on received orders. The online concierge system generates permutations of these task units to generate candidate sets of task batches. The online concierge system scores each of these candidate sets, and selects a set of task batches to assign to pickers based on the scores. Additionally, to determine which task UI to display to the picker, the picker client device uses a UI state machine. The UI state machine is a state machine where each state corresponds to a task UI to display on the picker client device. The state transitions between the UI states of the UI state machine indicate which UI state to transition to from a current UI state based on the next task unit in the received task batch.

Abstract: A multi-piece snow sled designed to be transported in a compact form then assembled into a full-sized sled, and more specifically a multi-piece snow sled designed to be transported in a compact form then assembled into a full-sized sled having a rigid floor. The multi-piece sled comprises a front sled body piece, a rear sled body piece, a front interface edge, a rear interface edge, and a plurality of removable fasteners securing the front interface edge to the rear interface edge.

Abstract: Nucleic acid molecules that include a nucleotide sequence encoding a chimeric antigen receptor (CAR) and a nucleotide sequence encoding a protease sensitive scFv, wherein the chimeric antigen receptor comprises: an scFv targeting a tumor antigen, a spacer, a transmembrane domain, a co-stimulatory domain, and a CD3? signaling domain; and the protease-sensitive scFv and the scFv target the same tumor antigen are described.

Abstract: Low power MASER (Microwave Amplification by Stimulated Emission of Radiation) radiation is used to non-invasively record molecular activity in a biological object such as a brain. Low power MASER radiation is also used to neuromodulate molecular targets via Rabi coupling, resulting for example in conformational and function change in specific molecular targets such as ligand-gated ion channels, voltage-gated ion channels, G-proteins, or dopamine receptors. The method can be used to change the energy state of targeted molecules via energization or enervation, or to ablate targeted molecules.

Abstract: Systems and methods of implementing a finite-state machine using electronic notifications delivered to a client device in a computer networking environment are provided. A content item can be received, along with first and second notifications associated with the content item. The first and second notifications can be stored in a queue. In some implementations, a state machine can be maintained in which at least some states may cause the first or second notifications to be displayed, and in which transitional conditions between states may depend at least in part on user interaction with the displayed notifications.

Abstract: Systems and methods of implementing a finite-state machine using electronic notifications delivered to a client device in a computer networking environment are provided. A content item can be received, along with first and second notifications associated with the content item. The first and second notifications can be stored in a queue. In some implementations, a state machine can be maintained in which at least some states may cause the first or second notifications to be displayed, and in which transitional conditions between states may depend at least in part on user interaction with the displayed notifications.

Abstract: Provided are Siglec-based chimeric polypeptides. Accordingly there is provided a chimeric receptor comprising: (a) an extracellular domain comprising an amino acid sequence of a Siglec-7 or a Siglec-9 receptor capable of binding a Siglec-7 and/or a Siglec-9 ligand; and (b) an intracellular domain comprising an amino acid sequence capable of transmitting a co-stimulatory signal in an immune cell expressing the chimeric receptor upon binding of said extracellular domain to said ligand. Also provided are polynucleotides encoding same, cells expressing same and methods of use thereof.

Abstract: A wearable respiratory isolation system is configured as an open collar to be worn loosely around the neck of the user, with an articulating arm positioning a mouthpiece in front of the mouth and nasal region of the user. The system provides filtered and sterilized air through a inhalation vent on the mouthpiece which creates a curtain of sterilized air in front of the users face, which protects the users face from air bourne pathogens provides sterile air for the user to inhale. Exhaled air is extracted through an exhalation vent on the mouthpiece, is decontaminated and exhausted to the rear of the user. A modified, background oriented Schlieren imaging technique is used to determine whether the user is inhaling or exhaling, and this information is used to control the flow of sterilized air and the capture of exhaled gases.

Abstract: A wipe comprising a flexible body is disclosed herewith. The wipe may be provided as a component of a wipe and a bag kit having the wipe and a bag, the wipe disposed within the bag. The wipe comprises a flexible body having an open end. The flexible body may be constructed of fabric. The wipe can be shaped and dimensioned complementary to a human male penis such that the human male penis may be inserted into the open end. The wipe may be pre-wetted with water and one or more additives.

Abstract: Systems and methods of implementing a finite-state machine using electronic notifications delivered to a client device in a computer networking environment are provided. A content item can be received, along with first and second notifications associated with the content item. The first and second notifications can be stored in a queue. In some implementations, a state machine can be maintained in which at least some states may cause the first or second notifications to be displayed, and in which transitional conditions between states may depend at least in part on user interaction with the displayed notifications.

Abstract: Low power MASER (Microwave Amplification by Stimulated Emission of Radiation) radiation is used to non-invasively record molecular activity in a biological object such as a brain. Low power MASER radiation is also used to neuromodulate molecular targets via Rabi coupling, resulting for example in conformational and function change in specific molecular targets such as ligand-gated ion channels, voltage-gated ion channels, G-proteins, or dopamine receptors. The method can be used to change the energy state of targeted molecules via energization or enervation, or to ablate targeted molecules.

Abstract: A phased-array MASER detector for synthetic aperture interferometric three-dimensional imaging. The detector elements, for example 102-106 zero bias Schottky detector diodes with sufficient sensitivity to reliably detect various values of MASER radiation, are arranged in layers offset in three dimensions. The phased-array MASER detector is particularly useful for detecting characteristics in a biological object using low energy (2-10 Watts), coherent MASER radiation. MASER intensity data of an interferometric pattern is collected by the detector array, is deconvolved, and is used to generate three-dimensional energy activity maps for a given time slice or on a time-shifting basis.

Abstract: A MASER (Microwave Amplified Stimulated Emission of Radiation) emitter is fabricated of thin film components, including a thin film of nitrogen-implanted, epitaxial crystal diamond. The MASER elements can also include a controllable Q-switching layer and be arranged in a thin panel, phased array to generate a single beam of coherent, mode-locked, continuous wave MASER radiation.