Abstract: A multi-piece snow sled designed to be transported in a compact form then assembled into a full-sized sled, and more specifically a multi-piece snow sled designed to be transported in a compact form then assembled into a full-sized sled having a rigid floor. The multi-piece sled comprises a front sled body piece, a rear sled body piece, a front interface edge, a rear interface edge, and a plurality of removable fasteners securing the front interface edge to the rear interface edge.

Abstract: Systems and methods of implementing a finite-state machine using electronic notifications delivered to a client device in a computer networking environment are provided. A content item can be received, along with first and second notifications associated with the content item. The first and second notifications can be stored in a queue. In some implementations, a state machine can be maintained in which at least some states may cause the first or second notifications to be displayed, and in which transitional conditions between states may depend at least in part on user interaction with the displayed notifications.

Abstract: A wearable respiratory isolation system is configured as an open collar to be worn loosely around the neck of the user, with an articulating arm positioning a mouthpiece in front of the mouth and nasal region of the user. The system provides filtered and sterilized air through a inhalation vent on the mouthpiece which creates a curtain of sterilized air in front of the users face, which protects the users face from air bourne pathogens provides sterile air for the user to inhale. Exhaled air is extracted through an exhalation vent on the mouthpiece, is decontaminated and exhausted to the rear of the user. A modified, background oriented Schlieren imaging technique is used to determine whether the user is inhaling or exhaling, and this information is used to control the flow of sterilized air and the capture of exhaled gases.

Abstract: A concierge system sends batches of orders to pickers that they can review and accept in a batch list on a client device. Each batch in the batch list is presented with a hide option that enables the picker to hide a batch that they do not intend to accept. In response to receiving a hide signal, the system extracts features associated with the batch and stores those features with a negative indication of the picker towards the batch. The hide signal provides the system with a higher quality signal indicating the picker's negative intent regarding an order, as compared to simply ignoring the order in favor of fulfilling another order. This higher quality signal is then used to train models to better predict events related to the pickers' acceptance of orders, such as for ranking orders for pickers or for predicting fulfillment times.

Abstract: Systems and methods of implementing a finite-state machine using electronic notifications delivered to a client device in a computer networking environment are provided. A content item can be received, along with first and second notifications associated with the content item. The first and second notifications can be stored in a queue. In some implementations, a state machine can be maintained in which at least some states may cause the first or second notifications to be displayed, and in which transitional conditions between states may depend at least in part on user interaction with the displayed notifications.

Abstract: The invention relates to a three-dimensional cellular microcompartment or a three-dimensional cellular microcompartment assembly comprising at least one external hydrogel layer and inside said external layer at least one layer of cells and/or at least one cellular base layer, of which less than 20% of the total population of cells present in the microcompartment or in the microcompartment assembly are cells having at least one mutation. The invention also relates to a method for producing such a microcompartment or microcompartment assembly.

Abstract: Nucleic acid molecules that include a nucleotide sequence encoding a chimeric antigen receptor (CAR) and a nucleotide sequence encoding a protease sensitive scFv, wherein the chimeric antigen receptor comprises: an scFv targeting a tumor antigen, a spacer, a transmembrane domain, a co-stimulatory domain, and a CD3 ? signaling domain; and the protease-sensitive scFv and the scFv target the same tumor antigen are described.

Abstract: An online concierge system iteratively makes a batch of one or more orders available to an increasing number of shoppers to choose to fulfill. Each shopper may choose to accept or reject a batch for fulfillment. To improve batch acceptance and matching between batches and shoppers, the batches are scored with respect to expected resource costs, likelihood of acceptance by the shopper, and/or other quality metrics to iteratively offer the batch to an increasing number of shoppers (prioritizing the scoring factors) until a shopper accepts. The number of shoppers notified of the batch and the frequency that additional shoppers are selected may vary based on characteristics of the batch and likelihood the batch will be accepted by a shopper.

Abstract: The online concierge system generates task units based on orders and assigns batches of task units to pickers. The online concierge system generates task units based on received orders. The online concierge system generates permutations of these task units to generate candidate sets of task batches. The online concierge system scores each of these candidate sets, and selects a set of task batches to assign to pickers based on the scores. Additionally, to determine which task UI to display to the picker, the picker client device uses a UI state machine. The UI state machine is a state machine where each state corresponds to a task UI to display on the picker client device. The state transitions between the UI states of the UI state machine indicate which UI state to transition to from a current UI state based on the next task unit in the received task batch.

Abstract: A multi-piece snow sled designed to be transported in a compact form then assembled into a full-sized sled, and more specifically a multi-piece snow sled designed to be transported in a compact form then assembled into a full-sized sled having a rigid floor. The multi-piece sled comprises a front sled body piece, a rear sled body piece, a front interface edge, a rear interface edge, and a plurality of removable fasteners securing the front interface edge to the rear interface edge.

Abstract: Nucleic acid molecules that include a nucleotide sequence encoding a chimeric antigen receptor (CAR) and a nucleotide sequence encoding a protease sensitive scFv, wherein the chimeric antigen receptor comprises: an scFv targeting a tumor antigen, a spacer, a transmembrane domain, a co-stimulatory domain, and a CD3? signaling domain; and the protease-sensitive scFv and the scFv target the same tumor antigen are described.

Abstract: Low power MASER (Microwave Amplification by Stimulated Emission of Radiation) radiation is used to non-invasively record molecular activity in a biological object such as a brain. Low power MASER radiation is also used to neuromodulate molecular targets via Rabi coupling, resulting for example in conformational and function change in specific molecular targets such as ligand-gated ion channels, voltage-gated ion channels, G-proteins, or dopamine receptors. The method can be used to change the energy state of targeted molecules via energization or enervation, or to ablate targeted molecules.

Abstract: Systems and methods of implementing a finite-state machine using electronic notifications delivered to a client device in a computer networking environment are provided. A content item can be received, along with first and second notifications associated with the content item. The first and second notifications can be stored in a queue. In some implementations, a state machine can be maintained in which at least some states may cause the first or second notifications to be displayed, and in which transitional conditions between states may depend at least in part on user interaction with the displayed notifications.

Abstract: Systems and methods of implementing a finite-state machine using electronic notifications delivered to a client device in a computer networking environment are provided. A content item can be received, along with first and second notifications associated with the content item. The first and second notifications can be stored in a queue. In some implementations, a state machine can be maintained in which at least some states may cause the first or second notifications to be displayed, and in which transitional conditions between states may depend at least in part on user interaction with the displayed notifications.

Abstract: Provided are Siglec-based chimeric polypeptides. Accordingly there is provided a chimeric receptor comprising: (a) an extracellular domain comprising an amino acid sequence of a Siglec-7 or a Siglec-9 receptor capable of binding a Siglec-7 and/or a Siglec-9 ligand; and (b) an intracellular domain comprising an amino acid sequence capable of transmitting a co-stimulatory signal in an immune cell expressing the chimeric receptor upon binding of said extracellular domain to said ligand. Also provided are polynucleotides encoding same, cells expressing same and methods of use thereof.

Abstract: A wearable respiratory isolation system is configured as an open collar to be worn loosely around the neck of the user, with an articulating arm positioning a mouthpiece in front of the mouth and nasal region of the user. The system provides filtered and sterilized air through a inhalation vent on the mouthpiece which creates a curtain of sterilized air in front of the users face, which protects the users face from air bourne pathogens provides sterile air for the user to inhale. Exhaled air is extracted through an exhalation vent on the mouthpiece, is decontaminated and exhausted to the rear of the user. A modified, background oriented Schlieren imaging technique is used to determine whether the user is inhaling or exhaling, and this information is used to control the flow of sterilized air and the capture of exhaled gases.