Abstract: The invention provides substituted piperidinyl-methylpurine pyridines and related compounds, pharmaceutical compositions, their use for inhibiting NSD2, and their use in the treatment of a disease or condition, such as cancer.

Abstract: The invention provides carbohydrate-functionalized piperidinyl-methylpurine pyridines and related compounds, pharmaceutical compositions, their use for inhibiting NSD2, and their use in the treatment of a disease or condition, such as cancer.

Abstract: The invention provides heterobicyclic-methylpurine pyridines and related compounds, pharmaceutical compositions, their use for inhibiting NSD2, and their use in the treatment of a disease or condition, such as cancer.

Abstract: The invention provides deuterium-enriched piperidinyl-methyl-purine amines and related compounds, pharmaceutical compositions, their use for inhibiting NSD2, and their use in the treatment of a disease or condition, such as cancer.

Abstract: Techniques for managing dataset resource instance performance via a data-centric approach are disclosed. A system determines an aggregated level of service demands placed on individual dataset resource instances that may be in a distributed computing system. The system may identify portions of a dataset that are associated with high levels of service demands. Once identified, the system may provide an administrator with the service demand information. The administrator may relocate these high demand dataset portions to other dataset resource instances that are better able to respond to the high levels of demand without impaired performance.

Abstract: The invention provides pharmaceutical compositions comprising a piperidinyl-methyl-purine amine and their use for inhibiting NSD2 and treating a disease or condition, such as cancer.

Abstract: Delivery systems for liquid embolics and methods of using them are disclosed. The devices generally include a catheter and one or more retention elements to limit migration of the liquid embolic to non-target sites.

Abstract: The invention provides piperidinyl-methyl-purine amine D-tartaric acid salts, crystalline forms, pharmaceutical compositions, their use in inhibiting NSD2, and their use in the treatment of a disease or condition, such as cancer.

Abstract: Provided herein are methods and intermediates for making (1R, 2R, 5R)-5-amino-2-methylcyclohexanol hydrochloride, which are useful for the preparation of compounds useful for the treatment of a disease, disorder, or condition associated with the JNK pathway.

Abstract: Techniques for managing dataset resource instance performance via a data-centric approach are disclosed. A system determines an aggregated level of service demands placed on individual dataset resource instances that may be in a distributed computing system. The system may identify portions of a dataset that are associated with high levels of service demands. Once identified, the system may provide an administrator with the service demand information. The administrator may relocate these high demand dataset portions to other dataset resource instances that are better able to respond to the high levels of demand without impaired performance.

Abstract: Expandable occlusive plugs and methods of using them are disclosed. The devices generally include a tubular body bearing multiple slits defining leaves, which expand radially outward when the ends of the device are brought toward one another.

Abstract: Provided herein are methods and intermediates for making (1R,2R,5R)-5-amino-2-methylcyclohexanol hydrochloride, which are useful for the preparation of compounds useful for the treatment of a disease, disorder, or condition associated with the JNK pathway.

Abstract: Delivery systems for liquid embolics and methods of using them are disclosed. The devices generally include a catheter and one or more retention elements to limit migration of the liquid embolic to non-target sites.

Abstract: Expandable occlusive plugs and methods of using them are disclosed. The devices generally include an expandable framework at least partially covered by a membrane. The occlusive plugs can be used for occlusion of body lumens and/or to limit migration of embolic agents to non-target sites.

Abstract: Provided herein are methods and intermediates for making (1R,2R,5R)-5-amino-2-methylcyclohexanol hydrochloride, which are useful for the preparation of compounds useful for the treatment of a disease, disorder, or condition associated with the JNK pathway.

Abstract: Provided herein are methods and intermediates for making (1R,2R,5R)-5-amino-2-methylcyclohexanol hydrochloride, which are useful for the preparation of compounds useful for the treatment of a disease, disorder, or condition associated with the JNK pathway.

Abstract: Provided herein are methods and intermediates for making (1R,2R,5R)-5-amino-2-methylcyclohexanol hydrochloride, which are useful for the preparation of compounds useful for the treatment of a disease, disorder, or condition associated with the JNK pathway.

Abstract: A cutting tool for performing cutting operations on a workpiece when the cutting tool is rotated about a central axis by a machine tool, the cutting tool includes a generally cylindrical body disposed about the central axis. The generally cylindrical body includes a first end and an opposite second end. The cutting tool further includes a cutting portion and a mounting portion. The cutting portion is disposed at or about the first end of the generally cylindrical body and includes a number of cutting edges structured to engage the workpiece during cutting operations. The mounting portion is disposed at or about the opposite second end of the generally cylindrical body and is structured to be coupled to the machine tool. At least a portion of the generally cylindrical body comprises a molded portion formed via a molding process about the cutting portion in a manner that couples the cutting portion to the generally cylindrical body.

Abstract: Provided herein are methods and intermediates for making (1R,2R,5R)-5-amino-2-methylcyclohexanol hydrochloride, which are useful for the preparation of compounds useful for the treatment of a disease, disorder, or condition associated with the JNK pathway.

Abstract: Provided herein are methods and intermediates for making (1R,2R,5R)-5-amino-2-methylcyclohexanol hydrochloride, which are useful for the preparation of compounds useful for the treatment of a disease, disorder, or condition associated with the JNK pathway.