Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract: Disclosed herein are compositions comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell. Also disclosed herein are methods of treating cancer in a subject, comprising: providing a composition comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell; and treating the cancer by administering a therapeutically effective dosage of the composition to the subject.

Abstract: A three-dimensionally printed structure is provided. The three-dimensionally printed structure includes a first layer composed at least in part of a first material; a second layer composed at least in part of the first material, the second layer being positioned over, under, or through the first layer and having an interface with the first layer; and a first internal structure composed at least in part of a second material different from the first material, the first internal structure being situated in both the first layer and the second layer.

Abstract: An automatic card shuffler to shuffle eight decks of cards (or less) and deal a round of Baccarat. The automatic shuffler comprises two pre-shuffle bins, each receiving approximately four decks of cards wherein the pre-shuffle bins are spaced apart from one another with card slides directing to a card-receiving area. Cards are randomly selected from the cards in each of the pre-shuffle bins and propelled onto the card slides directing the cards to the card-receiving area. Once a sufficient number of buffer cards (e.g., seven) have been deposited into the card-receiving area, a card flipper moves the seven cards against a face plate of an integral dealing shoe. A buffer-holder member maintains the buffer cards against the face plate for dealing as the card flipper returns to a home position to receive more shuffled cards while buffer cards are being dealt in a round of Baccarat.

Abstract: A three-dimensionally printed structure is provided. The three-dimensionally printed structure includes a first layer composed at least in part of a first material; a second layer composed at least in part of the first material, the second layer being positioned over, under, or through the first layer and having an interface with the first layer; and a first internal structure composed at least in part of a second material different from the first material, the first internal structure being situated in both the first layer and the second layer.

Abstract: An automatic card shuffler to shuffle eight decks of cards (or less) and deal a round of Baccarat. The automatic shuffler comprises two pre-shuffle bins, each receiving approximately four decks of cards wherein the pre-shuffle bins are spaced apart from one another with card slides directing to a card-receiving area. Cards are randomly selected from the cards in each of the pre-shuffle bins and propelled onto the card slides directing the cards to the card-receiving area. Once a sufficient number of buffer cards (e.g., seven) have been deposited into the card-receiving area, a card flipper moves the seven cards against a face plate of an integral dealing shoe. A buffer-holder member maintains the buffer cards against the face plate for dealing as the card flipper returns to a home position to receive more shuffled cards while buffer cards are being dealt in a round of Baccarat.

Abstract: A method and apparatus are disclosed for measuring polarization of electromagnetic illumination. The method includes the steps of modulating a polarization state of illumination received from a target object to generate modulated intensity illumination, selectively measuring an intensity of the modulated intensity illumination by periodically gating an exposure of an imaging device to the modulated intensity illumination at a first gating frequency; responsive to the measured intensity, determining polarization parameters of the received illumination, and generating image data corresponding to the target object with a plurality of the polarization parameters, wherein the illumination from the target object is modulated in accordance with a first frequency and the first gating frequency is associated with and synchronized with at least the first frequency.

Abstract: A method and apparatus are disclosed for measuring polarisation of electromagnetic illumination. The method includes the steps of modulating a polarisation state of illumination received from a target object to generate modulated intensity illumination, selectively measuring an intensity of the modulated intensity illumination by periodically gating an exposure of an imaging device to the modulated intensity illumination at a first gating frequency; responsive to the measured intensity, determining polarisation parameters of the received illumination, and generating image data corresponding to the target object with a plurality of the polarisation parameters, wherein the illumination from the target object is modulated in accordance with a first frequency and the first gating frequency is associated with and synchronised with at least the first frequency.

Abstract: A method of determining multi-level printing parameters for a printing device includes identifying printing parameters for each of multiple colorant levels; providing at least one density measurement at a known coverage for each colorant level; providing an aim curve relating input tone value to printed density value; and identifying multiple test parameter sets. The method further includes, for each of the test parameter sets at each of multiple input tone values, determining a printed density value based on the parameters of the test parameter set and the density measurements, and determining an error value from differences between the determined printed density values and the aim curve. The method also includes selecting one of the test parameter sets using the determined error values; and communicating the selected one of the plurality of test parameter sets for receipt by the printing device for printing documents. Systems and software can employ the method.

Abstract: A single deck shuffler includes a pre-shuffle bin, card-selector assembly, drive wheel and post-shuffle bin. The pre-shuffle bin is configured to accept a single deck of cards. While in the pre-shuffle bin, a modest downward force is applied to the single deck of cards. A base of the pre-shuffle bin is an independent member that selectively raises and lowers the deck of cards pursuant to a randomly-selected card number (e.g., 1-52). Once positioned correctly based on the randomly-selected card number, an upper body of the card-selector assembly moves forward to push a number of cards off the top of the deck corresponding to the randomly-selected card number thereby exposing a bottom card (i.e., the randomly-selected card) to a drive wheel. The drive wheel propels the card from the pre-shuffle bin into the post-shuffle bin. The process is repeated until each card is propelled into the post-shuffle bin.

Abstract: Emission event data of an object of interest is acquired with a detector comprising a plurality of rings defining corresponding slices. Also, an amount of motion for each of a plurality of segments is determined with one or more processing units, wherein each segment corresponds to less than an axial field of view (AFOV) of the detector. Further, motion mitigation is performed for segments for which the amount of motion satisfies a threshold to provide motion mitigated data, and not performed for segments for which the amount of motion does not satisfy the threshold to provide non-mitigated data. An image is reconstructed using the motion mitigated data and the non-mitigated data, and the image is displayed on a display.

Abstract: A method is provided that includes acquiring, with a detector comprising a plurality of rings defining corresponding slices, emission event data of an object of interest. The method also includes determining, with one or more processing units, an amount of motion for each of a plurality of segments, wherein each segment corresponds to less than an axial field of view (AFOV) of the detector. Further, the method includes performing, with the one or more processing units, motion mitigation for segments for which the amount of motion satisfies a threshold to provide motion mitigated data, and not performing motion mitigation for segments for which the amount of motion does not satisfy the threshold to provide non-mitigated data. Also, the method includes reconstructing an image using the motion mitigated data and the non-mitigated data. The method also includes displaying the image on a display.

Abstract: A method and system for displaying a physiologic waveform. The method and system acquire positron emission tomography (PET) coincidence event data of an object of interest. The method and system further select a subset of the PET coincidence event data corresponding to a time window and apply a multivariate data analysis technique to the subset of the PET coincidence event data. The method and system also generate a physiologic waveform based on the multivariate data analysis, and display the physiologic waveform on a display.

Abstract: A mobile computing device includes a processor and a trigger device operatively attached to the mobile computing device and configured to generate a mechanical vibration pattern for selectively actuating the mobile computing device. A trigger interface, illustratively an accelerometer, is configured to convert the mechanical vibration pattern into an electrical signal pattern. The processor is configured to actuate a mobile computing function depending on the mechanical vibration pattern generated by the trigger device. A table of properties stored in memory correlates the mechanical vibration generated by the trigger device with a specific mobile computing function. The trigger device may include a plurality of trigger parts; and the mechanical vibration pattern generated by the trigger device may include multiple bits of data generated by the plurality of trigger parts. The mobile computing device may be in a candy bar, clam shell, or other form factor and may include a removable handle.

Abstract: A method for selecting data to reconstruct a three-dimensional (3D) image of a subject of interest includes acquiring a 3D emission dataset of the subject of interest, acquiring a respiratory signal of the subject of interest, the respiratory signal including a plurality of respiratory cycles, and calculating a respiratory profile using the respiratory signal. The method further includes, for each respiratory cycle, generating a gating window, calculating a minimum total squared difference (TSD) between a plurality of phases in the respiratory profile and the same plurality of phases in the respiratory cycle, and positioning the gating window based on the TSD values calculated, and reconstructing a 3D image using only the emission data within the plurality of gated windows. A system and non-transitory computer readable medium are also described herein.

Abstract: A splint system includes a first base member including at least one connector portion. A second base member including at least one connector portion having a cavity, wherein an interior surface of the cavity includes slidable portions and coupling portions, the first and second base members being aligned to form a longitudinal passage. A shaft member is disposed in the longitudinal passage, and when the coupling portions of the shaft member align with the coupling portions of the second base member, the first and second base members are fixed relative to each other.

Abstract: A method for selecting data to reconstruct a three-dimensional (3D) image of a subject of interest includes acquiring a 3D emission dataset of the subject of interest, acquiring a respiratory signal of the subject of interest, the respiratory signal including a plurality of respiratory cycles, and calculating a respiratory profile using the respiratory signal. The method further includes, for each respiratory cycle, generating a gating window, calculating a minimum total squared difference (TSD) between a plurality of phases in the respiratory profile and the same plurality of phases in the respiratory cycle, and positioning the gating window based on the TSD values calculated, and reconstructing a 3D image using only the emission data within the plurality of gated windows. A system and non-transitory computer readable medium are also described herein.

Abstract: A hydrogen-storage-material comprising ammonia borane and poly(ethylene oxide).

Abstract: A mobile computing device includes a processor and a trigger device operatively attached to the mobile computing device and configured to generate a mechanical vibration pattern for selectively actuating the mobile computing device. A trigger interface, illustratively an accelerometer, is configured to convert the mechanical vibration pattern into an electrical signal pattern. The processor is configured to actuate a mobile computing function depending on the mechanical vibration pattern generated by the trigger device. A table of properties stored in memory correlates the mechanical vibration generated by the trigger device with a specific mobile computing function. The trigger device may include a plurality of trigger parts; and the mechanical vibration pattern generated by the trigger device may include multiple bits of data generated by the plurality of trigger parts. The mobile computing device may be in a candy bar, clam shell, or other form factor and may include a removable handle.

Abstract: A splint system includes a first base member including at least one connector portion. A second base member including at least one connector portion having a cavity, wherein an interior surface of the cavity includes slidable portions and coupling portions, the first and second base members being aligned to form a longitudinal passage. A shaft member is disposed in the longitudinal passage, and when the coupling portions of the shaft member align with the coupling portions of the second base member, the first and second base members are fixed relative to each other.