Abstract: In one embodiment, a brightness enhancement film comprises: a diffusing film comprising a front surface and a back surface, a coating on the front surface, and light redirecting structures disposed in the coating. The brightness enhancement film is capable of collimating light, and wherein, without the coating, the diffusing film would be capable of spread light passing through the back surface. In another embodiment, the brightness enhancement film comprises: a diffusing film comprising a front surface and a back surface, a coating on the front surface, and light redirecting structures disposed in the coating. The diffusing film has a stress retardation gradient of less than or equal to 50 nm/in, wherein an interval for calculation of the stress retardation gradient is less than 1 inch. The brightness enhancement film is capable of collimating light.

Abstract: The invention provides methods for treating neuropsychiatric disorders such as schizophrenia, Alzheimer's Disease, autism, depression, benign forgetfulness, childhood learning disorders, closed head injury, and attention deficit disorder. The methods entail administering to a patient diagnosed as having a neuropsychiatric disorder a pharmaceutical composition containing (i) a therapeutically effective amount of D-alanine (or a modified form thereof), provided that the composition is substantially free of D-cycloserine, and/or (ii) D-serine (or a modified form thereof), and/or (iii) 105 to 500 mg of D-cycloserine (or a modified form thereof), and/or (iv) N-methylglycine (or a modified form thereof).

Abstract: The invention provides methods for treating neuropsychiatric disorders such as schizophrenia, Alzheimer's Disease, autism, depression, benign forgetfulness, childhood learning disorders, closed head injury, and attention deficit disorder. The methods entail administering to a patient diagnosed as having a neuropsychiatric disorder a pharmaceutical composition containing (i) a therapeutically effective amount of D-alanine (or a modified form thereof), provided that the composition is substantially free of D-cycloserine, and/or (ii) D-serine (or a modified form thereof), and/or (iii) 105 to 500 mg of D-cycloserine (or a modified form thereof), and/or (iv) N-methylglycine (or a modified form thereof).

Abstract: Blends of oligomeric urethane multi(meth)acrylate; optionally at least one other monomer selected from the group consisting of acrylic monomers, styrenic monomers and ethylenically unsaturated nitrogen heterocycles, preferably a polyol multi(meth)acrylate; and nanoparticles of an ethylenically unsaturated, preferably (meth)acrylic-functionalized, titanium or zirconium compound can be cured by ultraviolet radiation in contact with a photoinitiator to produce optical resinous articles having high refractive indices, haze ratings of at most 5% and other properties which may be tailored according to the desired use.

Abstract: Optical articles, including light management films, prepared from brominated polycarbonate material are disclosed. The brominated polycarbonate provides a film exhibiting good light transmittance, high refractive index, good flame resistance, and good mechanical properties.

Abstract: Blends of monofunctional and multifunctional (meth)acrylate monomers, optionally in addition to oligomeric multifunctional (meth)acrylates), can be cured by ultraviolet radiation in contact with a photoinitiator to produce optical resinous articles having a glass transition temperature of at least 35° C. and having physical properties making them suitable for use as microstructure-bearing articles.

Abstract: An apparatus for producing a thermoplastic film having low-birefringent, low stress and at least one polished surface for optical media applications as well as low stress film for non-optical applications using a continuous extrusion process. The apparatus consists of a novel calendering roll in a calendering roll stack wherein, at least one roll consists of an inner steel shell, a resilient covering over the inner steel roll and a multi-layer metal sleeve outer covering of at least two layers. The metal sleeve preferably consists of three layers. The inner layer of the multi-layer outer sleeve is preferably nickel, the intermediate layer is preferably copper and the outer layer is preferably chrome with a highly polished surface. The film produced by the process has a retardation value (birefringence times thickness) of less than about 100 nanometers and a surface roughness of less than about 4 microinches.

Abstract: Blends of oligomeric urethane multi(meth)acrylate; optionally at least one other monomer selected from the group consisting of acrylic monomers, styrenic monomers and ethylenically unsaturated nitrogen heterocycles, preferably a polyol multi(meth)acrylate; and nanoparticles of an ethylenically unsaturated, preferably (meth)acrylic-functionalized, titanium or zirconium compound can be cured by ultraviolet radiation in contact with a photoinitiator to produce optical resinous articles having high refractive indices, haze ratings of at most 5% and other properties which may be tailored according to the desired use.

Abstract: Blends of monofunctional and multifunctional (meth)acrylate monomers, optionally in addition to oligomeric multifunctional (meth)acrylates), can be cured by ultraviolet radiation in contact with a photoinitiator to produce optical resinous articles having a glass transition temperature of at least 35° C. and having physical properties making them suitable for use as microstructure-bearing articles.

Abstract: The invention provides methods for treating neuropsychiatric disorders such as schizophrenia, Alzheimer's Disease, autism, depression, benign forgetfulness, childhood learning disorders, closed head injury, and attention deficit disorder. The methods entail administering to a patient diagnosed as having a neuropsychiatric disorder a pharmaceutical composition containing (i) a therapeutically effective amount of D-alanine (or a modified form thereof), provided that the composition is substantially free of D-cycloserine, and/or (ii) D-serine (or a modified form thereof), and/or (iii) 105 to 500 mg of D-cycloserine (or a modified form thereof), and/or (iv) N-methylglycine (or a modified form thereof).

Abstract: The invention provides methods for treating neuropsychiatric disorders such as schizophrenia, Alzheimer's Disease, autism, depression, benign forgetfulness, childhood learning disorders, close head injury, and attention deficit disorder. The methods entail administering to a patient diagnosed as having a neuropsychiatric disorder a pharmaceutical composition containing (i) a therapeutically effective amount of D-alanine (or a modified form thereof), provided that the composition is substantially free of D-cycloserine, and/or (ii) D-serine (or a modified form thereof), and/or (iii) 105 to 500 mg of D-cycloserine (or a modified form thereof), and/or (iv) N-methylglycine (or a modified form thereof).

Abstract: A method for producing articles bearing patterned microstructures, e.g., optical film, information carrying substrates for optical recording media, etc. includes applying a radiation curable coating material to a surface of a base film substrate, passing the base film substrate and uncured coating through a compression nip defined by a nip roll and a casting drum having pattern master of the microstructures. The method further includes curing the radiation curable coating by directing radiation energy through the base film substrate from the surface opposite the surface having the coating thereon while the coating is in contact with the drum, thus causing microstructure pattern to be replicated in the cured coating layer.

Abstract: A process for producing low birefringence and low stress thermoplastic polycarbonate film having a birefringence of less than about 20 nm from polycarbonate resin. The process consists of feeding a polycarbonate resin to an extruder, melting the polycarbonate resin, extruding the melted polycarbonate resin downwardly through an extrusion nozzle having the configuration of, forming a continuous film of melted resin, advancing the melted resin downwardly by essentially gravity into a gap between two calendering rolls which lie in a plane essentially perpendicular to the downward extrusion of the resin, cooling the polycarbonate film to below its glass transition temperature and advancing the cooled polymer to storage. The calendering rolls lie in a plane essentially perpendicular to the downward extrusion of the melted resin to wherein one roll is in a plane at an angle of about 30° from said perpendicular. The film is useful for optical media applications.

Abstract: The present invention provides methods of screening for ligands of target molecules. The methods of the present invention include assays in which a target molecule is subjected to denaturing conditions, and compounds are screened for the ability to alter the susceptibility of the target to unfolding. The methods of the present invention use fluorescence detection to determine that degree of unfolding of a target molecule. In some aspects of the present invention, fluorescence resonance energy transfer (FRET) is detected. In other aspects of the invention, fluorescence polarization (FP) is detected. In preferred embodiments, a target molecule such as a target protein is heated to a temperature, called TATLAS, at which at least a portion of the target molecule unfolds, in the presence of a test compound.

Abstract: An apparatus for producing a thermoplastic film having low-birefringent, low stress and at least one polished surface for optical media applications as well as low stress film for non-optical applications using a continuous extrusion process. The apparatus consists of a novel calendering roll in a calendering roll stack wherein, at least one roll consists of an inner steel shell, a resilient covering over the inner steel roll and a multi-layer metal sleeve outer covering of at least two layers. The metal sleeve preferably consists of three layers. The inner layer of the multi-layer outer sleeve is preferably nickel, the intermediate layer is preferably copper and the outer layer is preferably chrome with a highly polished surface.

Abstract: The invention provides methods for treating neuropsychiatric disorders such as schizophrenia, Alzheimer's Disease, autism, depression, benign forgetfulness, childhood learning disorders, close head injury, and attention deficit disorder. The methods entail administering to a patient diagnosed as having a neuropsychiatric disorder a pharmaceutical composition containing (i) a therapeutically effective amount of D- or L-phosphoserine.

Abstract: The invention provides methods for treating neuropsychiatric disorders such as schizophrenia, Alzheimer's Disease, autism, depression, benign forgetfulness, childhood learning disorders, close head injury, and attention deficit disorder. The methods entail administering to a patient diagnosed as having a neuropsychiatric disorder a pharmaceutical composition containing (i) a therapeutically effective amount of D-alanine (or a modified form thereof), provided that the composition is substantially free of D-cycloserine, and/or (ii) D-serine (or a modified form thereof), and/or (iii) 105 to 500 mg of D-cycloserine (or a modified form thereof), and/or (iv) N-methylglycine (or a modified form thereof).

Abstract: The invention provides methods for treating neuropsychiatric disorders such as schizophrenia, Alzheimer's Disease, autism, depression, benign forgetfulness, childhood learning disorders, close head injury, and attention deficit disorder. The methods entail administering to a patient diagnosed as having a neuropsychiatric disorder a pharmaceutical composition containing (i) a therapeutically effective amount of D-alanine (or a modified form thereof), provided that the composition is substantially free of D-cycloserine, and/or (ii) D-serine (or a modified form thereof), and/or (iii) 105 to 500 mg of D-cycloserine (or a modified form thereof), and/or (iv) N-methylglycine (or a modified form thereof).

Abstract: A die clamp assembly for an extruder comprises at least one passage through which product being extruded flows. The die clamp assembly is attached to an extruder and comprises a last barrel that is connectable to the extruder. The last barrel comprising a flange and the extruder and last barrel define at least one passage through which product flows; at least one die body comprising at least one die body passage that communicates with the at least one passage; and at least one die plate that comprises at least one die plate passage that communicates with the die body passage and at least one opening so product can be extruded from the at least one opening. A clamp collar assembly connects corresponding peripheral surfaces of the last barrel to the die body, and comprises a closed position that connects the last barrel to the die body and an open position that permits separation of the last barrel and the die body.

Abstract: A die clamp assembly for an extruder comprises at least one passage through which product being extruded flows. The die clamp assembly is attached to an extruder and comprises at least one adapter plate that is connectable to the extruder. The die clamp assembly also comprises at least one adapter plate passage that communicates with the passage of the extruder; at least one die body comprising at least one die body passage that communicates with the adapter plate passage; and at least one die plate that comprises at least one die plate passage that communicates with the die body passage and at least one opening so product can be extruded from the at least one opening. A clamp collar assembly connects corresponding peripheral surfaces of the adapter plate to the die body, and comprises a closed position that connects the adapter plate to the die body and an open position that permits separation of the adapter plate and the die body.