Abstract: The invention provides microfluidic devices, methods for imaging cells, and methods for preparing such microfluidic devices. The microfluidic devices are contemplated to provide advantages for use in imaging of cells and subcellular compartments in an environment that mimics in vivo conditions. The microfluidic devices can used with a microscope equipped with an oil emersion objective lens.

Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the system is used to monitor how organ systems respond to agents such as toxins or medications. The system enables the precise and controlled delivery of these agents, which, in some implementations, enables the biomimetic dosing of drugs in humans to be mimicked.

Abstract: Mobility aid devices, such as crutches, provide improved ergonomics, comfort and support for the user. The crutches can include an axilla support that has a shape with a peak that fits in the center of the user's axilla area, an increased width for the pad area in the peaked region, a feature that curves upward and toward the user's back to prevent forward slippage of the axilla support, and a feature that includes upward curves or widened areas to prevent rearward slippage of the axilla support. The crutches can include a grip that has a wider rear portion when viewed from the top, a downward slope from rear to front, a front area that narrows and twists towards the outside from horizontal, an offset from the centerline of the crutches to the outside and a rear that is rotated outward from the support centerline when viewed from the top.

Abstract: Mobility aid devices, such as crutches, provide improved ergonomics, comfort and support for the user. The crutches can include an axilla support that has a shape with a peak that fits in the center of the user's axilla area, an increased width for the pad area in the peaked region, a feature that curves upward and toward the user's back to prevent forward slippage of the axilla support, and a feature that includes upward curves or widened areas to prevent rearward slippage of the axilla support. The crutches can include a grip that has a wider rear portion when viewed from the top, a downward slope from rear to front, a front area that narrows and twists towards the outside from horizontal, an offset from the centerline of the crutches to the outside and a rear that is rotated outward from the support centerline when viewed from the top.

Abstract: Mobility aid devices, such as crutches, provide improved ergonomics, comfort and support for the user. The crutches can include one or more linkage devices that provide a mechanism to link the crutches together and provide restrictions on the range of motion, improving confidence and safety of the crutch devices. A first linkage device can be designed to attach to an upper portion of the crutch frame or at the axilla support to be placed along a user's back. A second linkage device can be designed to wrap about a waist area of a user and attach to a central portion of the crutch frame or at the grip region. The first and second linkages may be used singularly or in combination.

Abstract: Mobility aid devices, such as crutches, provide improved ergonomics, comfort and support for the user. The crutches can include a frame configuration where a main frame member includes a lower adjustment pole extending therefrom and a secondary pole is attached to a lower end of the main pole and extends upward therefrom. An axilla support may be supported by the main pole and the secondary pole. Typically, the axilla support may be supported by upper adjustment poles that adjustably telescope from the tops of the main pole and the secondary pole. The frame configuration, or a conventional frame, may be used in a crutch that can be convertible between a crutch, such as a cuff crutch, and a cane.

Abstract: Mobility aid devices, such as crutches, provide improved ergonomics, comfort and support for the user. The crutches can include an axilla support that has a shape with a peak that fits in the center of the user's axilla area, an increased width for the pad area in the peaked region, a feature that curves upward and toward the user's back to prevent forward slippage of the axilla support, and a feature that includes upward curves or widened areas to prevent rearward slippage of the axilla support. The crutches can include a grip that has a wider rear portion when viewed from the top, a downward slope from rear to front, a front area that narrows and twists towards the outside from horizontal, an offset from the centerline of the crutches to the outside and a rear that is rotated outward from the support centerline when viewed from the top.

Abstract: The invention provides microfluidic devices, methods for imaging cells, and methods for preparing such microfluidic devices. The microfluidic devices are contemplated to provide advantages for use in imaging of cells and subcellular compartments in an environment that mimics in vivo conditions. The microfluidic devices can used with a microscope equipped with an oil emersion objective lens.

Abstract: A microfluidic device is provided. The microfluidic device includes a first transparent, solid support layer. A first polymeric layer defining at least one chamber is attached to the first transparent, solid support layer. A semi-permeable membrane is attached to the first polymeric layer. A second polymeric layer is attached to the opposite side of the semi-permeable membrane from the first polymeric layer. The second polymeric layer has a thickness of less than 300 microns and defines at least one chamber positioned to overlap with at least one chamber in the first polymeric layer. A first manifold structure is attached to an input end of at least one chamber and a second manifold structure is attached to an output end of at least one chamber.

Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the organ systems are fluidically connected with a constant-volume pump.

Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the system is used to monitor how organ systems respond to agents such as toxins or medications. The system enables the precise and controlled delivery of these agents, which, in some implementations, enables the biomimetic dosing of drugs in humans to be mimicked.

Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the system is used to monitor how organ systems respond to agents such as toxins or medications. The system enables the precise and controlled delivery of these agents, which, in some implementations, enables the biomimetic dosing of drugs in humans to be mimicked.

Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the organ systems are fluidically connected with a constant-volume pump.

Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the organ systems are fluidically connected with a constant-volume pump.

Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the organ systems are fluidically connected with a constant-volume pump.

Abstract: The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the system is used to monitor how organ systems respond to agents such as toxins or medications. The system enables the precise and controlled delivery of these agents, which, in some implementations, enables the biomimetic dosing of drugs in humans to be mimicked.

Abstract: The invention provides microfluidic devices, methods for imaging cells, and methods for preparing such microfluidic devices. The microfluidic devices are contemplated to provide advantages for use in imaging of cells and subcellular compartments in an environment that mimics in vivo conditions. The microfluidic devices can used with a microscope equipped with an oil emersion objective lens.

Abstract: Substrates that exhibit antimicrobial and/or antifungal characteristics that persist through the useful life of the substrate, and more particularly textile substrates infused with or covalently bound to well-dispersed antimicrobial nanoparticles, such as silver and/or copper nanoparticles, which exhibit persistent and demonstrable bacteriocidal, bacteriostatic, fungicidal, fungistatic behavior through numerous wash cycles. Methods of manufacturing such substrates are also provided.

Abstract: There is disclosed an apparatus for providing an ionized analyte for mass analysis by photon desorption comprising at least one layer for contacting an analyte, and a substrate on which said layer is deposited. Upon irradiation of said apparatus, said analyte desorbs and ionizes for analysis by mass spectrometry. The layer or layers of said apparatus comprise a continuous film, a discontinuous film or any combinations thereof.

Abstract: There is disclosed a method providing micro-scale devices, nano-scale devices, or devices having both nano-scale and micro-scale features. The method of the invention comprises fluidic assembly and various novel devices produced thereby. A variety of nanofluidic and molecular electronic type devices and structures having applications such as filtering and genetic sequencing are provided by the invention.