Abstract: The present invention relates, in part, to methods, compounds, and compositions of an autophagy pathway inhibitor in combination with a dual RAF/MEK inhibitor, for treating abnormal cell growth (e.g., cancer).

Abstract: A contact system for a horse back rider allows a rider to maintain contact between their boot and the stirrup of a saddle while riding. The rider wears magnetic footwear such as a riding boot with an affixed magnet. The stirrup has a contact patch that includes a plate of ferrous metal or another magnet oriented such that it attracts the magnetic footwear. The contact patch is positioned such that it will be proximate to the magnet in the footwear when riding. During normal riding maneuvers, magnetic attractive forces between the footwear and the contact patch will maintain contact between the rider's feet and the stirrup. However, if the rider falls, the magnetic attractive forces do not bind the rider's feet to the stirrup.

Abstract: The invention relates to the discovery that the dibenzodiazepinone analogues have growth inhibiting activities on tumorigenic cells that are driven by expression of RAS or mutated RAS. Thus the invention includes methods for inhibiting the activity of RAS using dibenzodiazepinone analogues; methods for inhibiting the growth of a RAS driven cancer cell using dibenzodiazepinone analogues; methods for inhibiting the growth of a RAS driven cancer using dibenzodiazepinone analogues; and methods for treating a subject having a RAS driven cancer using dibenzodiazepinone analogues.

Abstract: A downhole electricity transmission system utilizes the wall of an electrically conductive reelable pipe of which the other surface is covered by an electric insulating material to transmit electric signals and/or power to and/or from a downhole location of an underground borehole.