Patents by Inventor Joseph E. Dolfini

Joseph E. Dolfini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4927805
    Abstract: Curcumin is subjected to the action of heat and pressure in the presence of water by a continuous or batch process to produce vanillin and other natural flavor products. The proportion of vanillin in the final product varies with the pH of the reaction mixture.
    Type: Grant
    Filed: January 25, 1989
    Date of Patent: May 22, 1990
    Assignee: Mallinckrodt, Inc.
    Inventors: Joseph E. Dolfini, Jerome Glinka, Andrew C. Bosch
  • Patent number: 4871881
    Abstract: Ketones or aldehydes containing one or more carbon-carbon double bonds and a carbonyl group conjugated with at least one double bond are hydrolyzed by the action of heat and pressure in the presence of water by a batch or continuous process. The ketone or aldehyde cleaves at the double bond conjugated with the carbonyl group to produce additional carbonyl-containing compounds.
    Type: Grant
    Filed: February 21, 1989
    Date of Patent: October 3, 1989
    Assignee: Mallinckrodt, Inc.
    Inventors: Joseph E. Dolfini, Jerome Glinka
  • Patent number: 4810824
    Abstract: Ketones or aldehydes containing one or more carbon-carbon double bonds and a carbonyl group conjugated with at least one double bond are hydrolyzed by the action of heat and pressure in the presence of water by a batch or continuous process. The ketone or aldehyde cleaves at the double bond conjugated with the carbonyl group to produce additional carbonyl-containing compounds.
    Type: Grant
    Filed: November 20, 1987
    Date of Patent: March 7, 1989
    Assignee: Mallinckrodt, Inc.
    Inventors: Joseph E. Dolfini, Jerome Glinka
  • Patent number: 4766249
    Abstract: Alpha, beta-unsaturated carbonyl compounds are hydrolyzed under alkaline conditions in the presence of water to produce additional carbonyl-containing compounds. High yields are obtained when the alkaline catalyst contains hydroxide ion and the pH is maintained in the range of about 11 to about 13.
    Type: Grant
    Filed: December 24, 1986
    Date of Patent: August 23, 1988
    Assignee: Mallinckrodt, Inc.
    Inventors: Keith T. Buck, Anthony J. Boeing, Joseph E. Dolfini, Jerome Glinka
  • Patent number: 4709098
    Abstract: Ketones or aldehydes containing one or more carbon-carbon double bonds and a carbonyl group conjugated with at least one double bond are hydrolyzed by the action of heat and pressure in the presence of water. The ketone or aldehyde cleaves at the double bond conjugated with the carbonyl group to produce additional carbonyl-containing compounds.
    Type: Grant
    Filed: February 4, 1987
    Date of Patent: November 24, 1987
    Assignee: Mallinckrodt, Inc.
    Inventors: Joseph E. Dolfini, Jerome Glinka
  • Patent number: 4673766
    Abstract: A method is disclosed for producing benzaldehyde by fractionally steam distilling benzaldehyde from cinnamaldehyde in the presence of hydroxide catalyst and at a pH on the order of about 11 to about 13. Conversions of cinnamaldehyde to benzaldehyde can be achieved on the order of about 75% or more.
    Type: Grant
    Filed: April 25, 1986
    Date of Patent: June 16, 1987
    Assignee: Mallinckrodt, Inc.
    Inventors: Keith T. Buck, Anthony J. Boeing, Joseph E. Dolfini
  • Patent number: 4302581
    Abstract: Novel 7-(1,3-dithiolan-2-imino)cephalosporin derivatives are described which are particularly useful for their antibacterial properties.
    Type: Grant
    Filed: November 5, 1979
    Date of Patent: November 24, 1981
    Assignee: Richardson-Merrell Inc.
    Inventors: Boyd L. Harrison, Joseph E. Dolfini
  • Patent number: 4291160
    Abstract: Novel 7-(1,3-dithiolan-2-imino)-.DELTA..sup.2 -cephalosporanic acid derivatives are described which possess useful antibacterial properties.
    Type: Grant
    Filed: November 5, 1979
    Date of Patent: September 22, 1981
    Assignee: Richardson-Merrell Inc.
    Inventors: Boyd L. Harrison, Joseph E. Dolfini
  • Patent number: 4285957
    Abstract: Novel compounds of the following formula: ##STR1## wherein R.sub.1 is hydrogen or hydroxy; R.sub.2 is hydrogen; or R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ; n is an integer of from 1 to 5; R.sub.3 is --CH.sub.3, --CH.sub.2 OH, --COOH or --COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; and each of A and B is hydrogen or hydroxy; with the provisos that at least one of A or B is hydrogen and one of A or B is other than hydrogen when R.sub.3 is --CH.sub.3 ; and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: October 14, 1980
    Date of Patent: August 25, 1981
    Assignee: Richardson-Merrell Inc.
    Inventors: Albert A. Carr, Joseph E. Dolfini, George J. Wright
  • Patent number: 4285958
    Abstract: Pharmaceutically useful compounds of the following formula: ##STR1## wherein R.sub.1 represents hydrogen or hydroxy; R.sub.2 represents hydrogen; or R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ; n is a positive whole integer of from 1 to 5; R.sub.3 is --CH.sub.3, --CH.sub.2 OH, --COOH or --COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; and A and B are individually hydrogen or hydroxy; with the provisos that at least one of A or B is hydrogen and one of A or B is other than hydrogen when R.sub.3 is --CH.sub.3 ; and pharmaceutically acceptable acid addition salts thereof.
    Type: Grant
    Filed: October 14, 1980
    Date of Patent: August 25, 1981
    Assignee: Richardson-Merrell Inc.
    Inventors: Albert A. Carr, Joseph E. Dolfini, George J. Wright
  • Patent number: 4254129
    Abstract: Novel compounds of the following formula: ##STR1## wherein R.sub.1 is hydrogen or hydroxy; R.sub.2 is hydrogen; or R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ; n is an integer of from 1 to 5; R.sub.3 is --CH.sub.3, --CH.sub.2 OH, --COOH or --COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; and each of A and B is hydrogen or hydroxy; with the provisos that at least one of A or B is hydrogen and one of A or B is other than hydrogen when R.sub.3 is --CH.sub.3 ; and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: April 10, 1979
    Date of Patent: March 3, 1981
    Assignee: Richardson-Merrell Inc.
    Inventors: Albert A. Carr, Joseph E. Dolfini, George J. Wright
  • Patent number: 4254130
    Abstract: Pharmaceutically useful compounds of the following formula: ##STR1## wherein R.sub.1 represents hydrogen or hydroxy; R.sub.2 represents hydrogen; or R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ; n is a positive whole integer of from 1 to 5; R.sub.3 is --CH.sub.3, --CH.sub.2 OH, --COOH or --COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; and A and B are individually hydrogen or hydroxy; with the provisos that at least one of A or B is hydrogen and one of A or B is other than hydrogen when R.sub.3 is --CH.sub.3 ; and pharmaceutically acceptable acid addition salts thereof.
    Type: Grant
    Filed: April 10, 1979
    Date of Patent: March 3, 1981
    Assignee: Richardson-Merrell Inc.
    Inventors: Albert A. Carr, Joseph E. Dolfini, George J. Wright
  • Patent number: 4244955
    Abstract: 2,4a-Ethanobenz[g]isoquinolin-5(1H)-one derivatives are described which are useful as analgesic and anti-fertility agents.
    Type: Grant
    Filed: April 30, 1979
    Date of Patent: January 13, 1981
    Assignee: Richardson-Merrell Inc.
    Inventors: Robert A. Farr, Joseph E. Dolfini
  • Patent number: 4208516
    Abstract: Novel 7-(1,3-dithiolan-2-imino)-.DELTA..sup.2 -cephalosporanic acid derivatives are described which possess useful antibacterial properties.
    Type: Grant
    Filed: March 12, 1979
    Date of Patent: June 17, 1980
    Assignee: Richardson-Merrell Inc.
    Inventors: Boyd L. Harrison, Joseph E. Dolfini
  • Patent number: 4206305
    Abstract: Novel 7-(1,3-dithiolan-2-imino)cephalosporin derivatives are described which are particularly useful for their antibacterial properties.
    Type: Grant
    Filed: March 12, 1979
    Date of Patent: June 3, 1980
    Assignee: Richardson-Merrell Inc.
    Inventors: Boyd L. Harrison, Joseph E. Dolfini
  • Patent number: 4206119
    Abstract: Novel 6-(1,3-dithiolan-2-imino)penicillanic acid derivatives are described which are particularly useful for their antibacterial properties.
    Type: Grant
    Filed: March 12, 1979
    Date of Patent: June 3, 1980
    Assignee: Richardson-Merrell Inc.
    Inventors: Boyd L. Harrison, Joseph E. Dolfini
  • Patent number: 4172941
    Abstract: Novel 7-[2-[.omega.-(1,3-dithiolan-2-imino)substituted]-acetylamino]cephalospora nic acid derivatives are described having useful antibacterial activity.
    Type: Grant
    Filed: May 12, 1978
    Date of Patent: October 30, 1979
    Assignee: Richardson-Merrell Inc.
    Inventors: Boyd L. Harrison, Joseph E. Dolfini
  • Patent number: 4155905
    Abstract: Disclosed herein are penicillanic acids and derivatives thereof which are substituted in the 6-position, processes for preparing such compounds and the utility thereof. The compounds of the invention have been found to be useful as antibacterial agents.
    Type: Grant
    Filed: July 31, 1972
    Date of Patent: May 22, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joseph E. Dolfini, Ekkehard Bohme
  • Patent number: 4131683
    Abstract: .omega.-(1,3-Dithiolan-2-imino) substituted acetic acids are prepared useful as antibacterial agents, inhibitors of cholesterol and fatty acid synthesis, anti-inflammatory agents and as intermediates for cephalosporin antibiotics.
    Type: Grant
    Filed: May 12, 1978
    Date of Patent: December 26, 1978
    Assignee: Richardson-Merrell Inc.
    Inventors: Boyd L. Harrison, Joseph E. Dolfini
  • Patent number: 4098999
    Abstract: Disclosed herein are novel analogs of cephalosporins. They differ from prior art compounds in that they are substituted in the 2-position and can be prepared by reacting known cephalosporins with an active source of halogen to form a 2-halogenated intermediate. Substitution of the thus formed intermediate can be accomplished with various substitutents. The compounds of this invention are useful antimicrobial and antibacterial agents.
    Type: Grant
    Filed: August 21, 1974
    Date of Patent: July 4, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Joseph E. Dolfini