Patents by Inventor Joseph E. Hesselgesser

Joseph E. Hesselgesser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODULATORS OF TOLL-LIKE RECEPTORS FOR THE TREATMENT OF HIV
    Publication number: 20220062293
    Abstract: Provided are methods, uses, pharmaceutical regimens, pharmaceutical compositions, and kits comprising modulators of TLR7, including those of Formula II: and pharmaceutically acceptable salts thereof, useful in treating HIV infections.
    Type: Application
    Filed: August 10, 2021
    Publication date: March 3, 2022
    Inventors: Romas Geleziunas, Joseph E. Hesselgesser
  • Modulators of toll-like receptors for the treatment of HIV
    Patent number: 11116774
    Abstract: Provided are methods, uses, pharmaceutical regimens, pharmaceutical compositions, and kits comprising modulators of TLR7, including those of Formula II: and pharmaceutically acceptable salts thereof, useful in treating HIV infections.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: September 14, 2021
    Assignee: Gilead Sciences, Inc.
    Inventors: Romas Geleziunas, Joseph E. Hesselgesser
  • MODULATORS OF TOLL-LIKE RECEPTORS FOR THE TREATMENT OF HIV
    Publication number: 20180263985
    Abstract: Provided are methods, uses, pharmaceutical regimens, pharmaceutical compositions, and kits comprising modulators of TLR8 and pharmaceutically acceptable salts thereof, useful in treating HIV infections.
    Type: Application
    Filed: September 13, 2016
    Publication date: September 20, 2018
    Inventors: ROMAS GELEZIUNAS, JOSEPH E. HESSELGESSER, JASMINE KAUR, JEFFREY PATRICK MURRY, DEREK DEAN SLOAN
  • MODULATORS OF TOLL-LIKE RECEPTORS FOR THE TREATMENT OF HIV
    Publication number: 20170071944
    Abstract: Provided are methods, uses, pharmaceutical regimens, pharmaceutical compositions, and kits comprising modulators of TLR8 and pharmaceutically acceptable salts thereof, useful in treating HIV infections.
    Type: Application
    Filed: September 13, 2016
    Publication date: March 16, 2017
    Inventors: ROMAS GELEZIUNAS, Joseph E. Hesselgesser, Jasmine Kaur, Jeffrey Patrick Murry, Derek Dean Sloan
  • MODULATORS OF TOLL-LIKE RECEPTORS FOR THE TREATMENT OF HIV
    Publication number: 20160008374
    Abstract: Provided are methods, uses, pharmaceutical regimens, pharmaceutical compositions, and kits comprising modulators of TLR7, including those of Formula II: and pharmaceutically acceptable salts thereof, useful in treating HIV infections.
    Type: Application
    Filed: July 9, 2015
    Publication date: January 14, 2016
    Inventors: Romas Geleziunas, Joseph E. Hesselgesser
  • Piperazine derivatives and their use as anti-inflammatory agents
    Patent number: 7268140
    Abstract: This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.
    Type: Grant
    Filed: October 13, 2005
    Date of Patent: September 11, 2007
    Assignee: Schering AG
    Inventors: John G. Bauman, Brad O. Buckman, Ameen F. Ghannam, Joseph E. Hesselgesser, Richard Horuk, Imadul Islam, Meina Liang, Karen B. May, Sean D. Monahan, Michael M. Morrissey, Howard P. Ng, Kenneth J. Shaw, Guo Ping Wei, Wei Xu, Zuchun Zhao, Wei Zheng
  • Piperazine derivatives and their use as anti-inflammatory agents
    Patent number: 6977258
    Abstract: This invention is directed to acyl piperazine derivatives of formula (Ia): wherein R1a, R2, R3, R4, R5 and R6 are defined herein, which are useful as anti-inflammatory agents. This invention is also directed to other acyl piperazine derivatives, pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.
    Type: Grant
    Filed: January 17, 2003
    Date of Patent: December 20, 2005
    Assignee: Schering Aktiengesellschaft
    Inventors: John G. Bauman, Brad O. Buckman, Ameen F. Ghannam, Joseph E. Hesselgesser, Richard Horuk, Imadul Islam, Meina Liang, Karen B. May, Sean D. Monahan, Michael M. Morrissey, Howard P. Ng, Kenneth J. Shaw, Guo Ping Wei, Wei Xu, Zuchun Zhao, Wei Zheng
  • Piperazine derivatives and their use as anti-inflammatory agents
    Patent number: 6972290
    Abstract: This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.
    Type: Grant
    Filed: January 17, 2003
    Date of Patent: December 6, 2005
    Assignee: Schering Aktiengesellschaft
    Inventors: John G. Bauman, Brad O. Buckman, Ameen F. Ghannam, Joseph E. Hesselgesser, Richard Horuk, Imadul Islam, Meina Liang, Karen B. May, Sean D. Monahan, Michael M. Morrissey, Howard P. Ng, Kenneth J. Shaw, Guo Ping Wei, Wei Xu, Zuchun Zhao, Wei Zheng
  • Radiopharmaceuticals for diagnosing Alzheimer's disease
    Patent number: 6872381
    Abstract: This invention is directed to the use of radiopharmaceuticals in diagnosing Alzheimer's disease. In particular the radiopharmaceuticals of the invention are able to pass through the blood-brain barrier and bind to the CCR1 receptor present in brain tissue of patients having Alzheimer's disease.
    Type: Grant
    Filed: July 25, 2003
    Date of Patent: March 29, 2005
    Assignee: Schering AG
    Inventors: Christoph-Stephan Hilger, Bernd Johannsen, Joerg Steinbach, Peter Maeding, Meredith Halks-Miller, Richard Horuk, Harald Dinter, Raju Mohan, Joseph E. Hesselgesser
  • Radiopharmaceuticals for diagnosing Alzheimer's disease
    Patent number: 6676926
    Abstract: The compounds of formulas (I) and (II) are radiopharmaceuticals that bind to the CCR1 receptor and are able to pass through the blood-brain barrier, and are therefore useful in diagnosing Alzheimer's disease, preferably at an early stage of the disease, wherein X1, X2, R1, R2, R3, R4 and R5 are as defined herein.
    Type: Grant
    Filed: November 6, 2001
    Date of Patent: January 13, 2004
    Assignee: Schering Aktiengesellschaft
    Inventors: Christoph-Stephan Hilger, Bernd Johannsen, Joerg Steinbach, Peter Maeding, Meredith Halks-Miller, Richard Horuk, Harald Dinter, Raju Mohan, Joseph E. Hesselgesser
  • Piperazine derivatives and their use as anti-inflammatory agents
    Publication number: 20030158205
    Abstract: This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.
    Type: Application
    Filed: January 17, 2003
    Publication date: August 21, 2003
    Applicant: Schering Aktiengesellschaft
    Inventors: John G. Bauman, Brad O. Buckman, Ameen F. Ghannam, Joseph E. Hesselgesser, Richard Horuk, Imadul Islam, Meina Liang, Karen B. May, Sean D. Monahan, Michael M. Morrissey, Howard P. Ng, Kenneth J. Shaw, Guo Ping Wei, Wei Xu, Zuchun Zhao, Wei Zheng
  • Piperazine derivatives and their use as anti-inflammatory agents
    Publication number: 20030139425
    Abstract: This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.
    Type: Application
    Filed: January 17, 2003
    Publication date: July 24, 2003
    Applicant: Schering Aktiengesellschaft
    Inventors: John G. Bauman, Brad O. Buckman, Ameen F. Ghannam, Joseph E. Hesselgesser, Richard Horuk, Imadul Islam, Meina Liang, Karen B. May, Sean D. Monahan, Michael M. Morrissey, Howard P. Ng, Kenneth J. Shaw, Guo Ping Wei, Wei Xu, Zuchun Zhao, Wei Zheng
  • Piperazine derivatives and their use as anti-inflammatory agents
    Patent number: 6573266
    Abstract: This invention is directed to acyl piperazine derivatives of the following formula (Id): wherein R1b, R3, R4, R5, R6 and R10 are described herein. These derivatives are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the derivatives, and methods of using the derivatives to treat inflammatory disorders in humans.
    Type: Grant
    Filed: November 16, 2000
    Date of Patent: June 3, 2003
    Assignee: Schering Aktiengesellschaft
    Inventors: John G. Bauman, Brad O. Buckman, Ameen F. Ghannam, Joseph E. Hesselgesser, Richard Horuk, Imadul Islam, Meina Liang, Karen B. May, Sean D. Monahan, Michael M. Morrissey, Howard P. Ng, Kenneth J. Shaw, Guo Ping Wei, Wei Xu, Zuchun Zhao, Wei Zheng
  • Piperazine derivatives and their use as anti-inflammatory agents
    Patent number: 6555537
    Abstract: This invention is directed to acyl piperazine derivatives, for example, of the following formula (Ia): wherein R1a, R2, R3, R4, R5, and R6 are described herein. These derivatives are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the derivatives, and methods of using the derivatives to treat inflammatory disorders in humans.
    Type: Grant
    Filed: November 29, 2000
    Date of Patent: April 29, 2003
    Assignee: Schering Aktiengesellschaft
    Inventors: John G. Bauman, Brad O. Buckman, Ameen F. Ghannam, Joseph E. Hesselgesser, Richard Horuk, Imadul Islam, Meina Liang, Karen B. May, Sean D. Monahan, Michael M. Morrissey, Howard P. Ng, Kenneth J. Shaw, Guo Ping Wei, Wei Xu, Zuchun Zhao, Wei Zheng
  • Piperazine derivatives and their use as anti-inflammatory agents
    Patent number: 6541476
    Abstract: This invention is directed to acyl piperazine derivatives, for example, of the following formula (Ia): wherein R1a, R2, R3, R4, R5, and R6 are described herein. These derivatives are useful anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the derivatives, and methods of using the derivatives to treat inflammatory disorders in humans.
    Type: Grant
    Filed: November 14, 2000
    Date of Patent: April 1, 2003
    Assignee: Schering Aktiengesellschaft
    Inventors: John G. Bauman, Brad O. Buckman, Ameen F. Ghannam, Joseph E. Hesselgesser, Richard Horuk, Imadul Islam, Meina Liang, Karen B. May, Sean D. Monahan, Michael M. Morrissey, Howard P. Ng, Kenneth J. Shaw, Guo Ping Wei, Wei Xu, Zuchun Zhao, Wei Zheng
  • Piperazine derivatives and their use as anti-inflammatory agents
    Patent number: 6534509
    Abstract: This invention is directed to acyl piperazine derivatives, for example, of the following formula (1a): wherein R1a, R2, R3, R4, R5, and R6are descried herein. These derivatives are useful as anti-inflammatory agents. This invention is also directed to pharmacetutical compostions containing the derivatives, and methods of using the derivatives to treat inflammatory disorders in humans.
    Type: Grant
    Filed: November 15, 2000
    Date of Patent: March 18, 2003
    Assignee: Schering Aktiengesellschaft
    Inventors: John G. Bauman, Brad O. Buckman, Ameen F. Ghannam, Joseph E. Hesselgesser, Richard Horuk, Imadul Islam, Meina Liang, Karen B. May, Sean D. Monahan, Michael M. Morrissey, Howard P. Ng, Kenneth J. Shaw, Guo Ping Wei, Wei Xu, Zuchun Zhao, Wei Zheng
  • Methods and compositions for modulating the interaction between the APJ receptor and the HIV virus
    Publication number: 20030008279
    Abstract: The orphan seven transmembrane domain receptor, APJ, can function as a coreceptor for cellular infection by the HIV virus. The establishment of cell lines that coexpress CD4 and APJ provide valuable tools for continuing research on HIV infection and the development of anti-HIV therapeutics.
    Type: Application
    Filed: June 11, 2002
    Publication date: January 9, 2003
    Applicant: Trustees of the University of Pennsylvania
    Inventors: Robert W. Doms, Daryl Faulds, Joseph E. Hesselgesser, Richard Horuk, Branislava Mitrovic, Yiqing Zhou
  • Methods and compositions for modulating the interaction between the APJ receptor and the HIV virus
    Publication number: 20030008376
    Abstract: The orphan seven transmembrane domain receptor, APJ, can function as a coreceptor for cellular infection by the HIV virus. The establishment of cell lines that coexpress CD4 and APJ provide valuable tools for continuing research on HIV infection and the development of anti-HIV therapeutics.
    Type: Application
    Filed: June 11, 2002
    Publication date: January 9, 2003
    Applicant: Trustees of the University of Pennsylvania
    Inventors: Robert W. Doms, Daryl Faulds, Joseph E. Hesselgesser, Richard Horuk, Branislava Mitrovic, Yiqing Zhou
  • Methods and compositions for modulating the interaction between the APJ receptor and the HIV virus
    Publication number: 20030008391
    Abstract: The orphan seven transmembrane domain receptor, APJ, can function as a coreceptor for cellular infection by the HIV virus. The establishment of cell lines that coexpress CD4 and APJ provide valuable tools for continuing research on HIV infection and the development of anti-HIV therapeutics.
    Type: Application
    Filed: June 11, 2002
    Publication date: January 9, 2003
    Applicant: Trustees of the University of Pennsylvania
    Inventors: Robert W. Doms, Daryl Faulds, Joseph E. Hesselgesser, Richard Horuk, Branislava Mitrovic, Yiqing Zhou
  • Methods and compositions for modulating the interaction between the APJ receptor and the HIV virus
    Publication number: 20030003447
    Abstract: The orphan seven transmembrane domain receptor, APJ, can function as a coreceptor for cellular infection by the HIV virus. The establishment of cell lines that coexpress CD4 and APJ provide valuable tools for continuing research on HIV infection and the development of anti-HIV therapeutics.
    Type: Application
    Filed: June 11, 2002
    Publication date: January 2, 2003
    Applicant: Trustees of the University of Pennsylvania
    Inventors: Robert W. Doms, Daryl Faulds, Joseph E. Hesselgesser, Richard Horuk, Branislava Mitrovic, Yiqing Zhou