Patents by Inventor Joseph E. Pero
Joseph E. Pero has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11999746Abstract: The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example Alzheimer's disease.Type: GrantFiled: July 29, 2019Date of Patent: June 4, 2024Assignee: GlaxoSmithKline Intellectual Property Development LimitedInventors: Zehong Wan, Xiaomin Zhang, Jian Wang, Matthew Robert Sender, Eric Steven Manas, Raphael Anthony Rivero, Joseph E Pero, Christopher Ernst Neipp, Vipulkumar Kantibhai Patel
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Patent number: 11260049Abstract: The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.Type: GrantFiled: September 20, 2017Date of Patent: March 1, 2022Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITEDInventors: Edward J. Brnardic, Carl A. Brooks, Brian Griffin Lawhorn, Peng Li, Jay M. Matthews, John Jeffrey McAtee, Joseph E. Pero, Matthew Robert Sender, Lamont Roscoe Terrell, David J. Behm
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Patent number: 11229623Abstract: The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.Type: GrantFiled: February 21, 2020Date of Patent: January 25, 2022Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITEDInventors: Edward J. Brnardic, Carl A. Brooks, Brian Griffin Lawhorn, Guosen Ye, Linda S. Barton, Brian W. Budzik, Jay M. Matthews, John Jeffrey McAtee, Jaclyn R. Patterson, Joseph E. Pero, Robert Sanchez, Matthew Robert Sender, Lamont Roscoe Terrell, David J. Behm, James V. Thomas
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Publication number: 20210299113Abstract: The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.Type: ApplicationFiled: September 20, 2017Publication date: September 30, 2021Inventors: Edward J. BRNARDIC, Carl A. BROOKS, Brian Griffin LAWHORN, Peng LI, Jay M. MATTHEWS, John Jeffrey McATEE, Joseph E. PERO, Matthew Robert SENDER, Lamont Roscoe TERRELL, David J. BEHM
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Publication number: 20210253528Abstract: The invention is directed to substituted carbon-linked bicycloalkane derivatives. Specifically, the invention is directed to compounds according to Formula (X): wherein C?, D?, L2?, L3?, R2?, R3?, R4?, R5?, R6?, R7?, R8?, z2?, z3?, z4?, z5?, z6?, X1, and X2 are as defined herein; or a salt thereof including a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: July 8, 2019Publication date: August 19, 2021Inventors: Michael P. DEMARTINO, Karen Anderson EVANS, Israil PENDRAK, Joseph E. PERO
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Publication number: 20200261411Abstract: The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.Type: ApplicationFiled: February 21, 2020Publication date: August 20, 2020Inventors: Edward J. BRNARDIC, Carl A. BROOKS, Brian Griffin LAWHORN, Guosen YE, Linda S. BARTON, Brian W. BUDZIK, Jay M. MATTHEWS, John Jeffrey McATEE, Jaclyn R. PATTERSON, Joseph E. PERO, Robert SANCHEZ, Matthew Robert SENDER, Lamont Roscoe TERRELL, David J. BEHM, James V. THOMAS
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Patent number: 10590077Abstract: The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.Type: GrantFiled: September 20, 2017Date of Patent: March 17, 2020Assignee: GlaxoSmithKline Intellectual Property Development LimitedInventors: Edward J. Brnardic, Carl A. Brooks, Brian W. Budzik, Brian Griffin Lawhorn, Jay M. Matthews, John Jeffrey McAtee, Joseph E. Pero, David J. Behm
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Patent number: 10588891Abstract: The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.Type: GrantFiled: September 20, 2017Date of Patent: March 17, 2020Assignee: GlaxoSmithKline Intellectual Property Development LimitedInventors: Edward J. Brnardic, Carl A. Brooks, Brian Griffin Lawhorn, Guosen Ye, Linda S. Barton, Brian W. Budzik, Jay M. Matthews, John Jeffrey McAtee, Jaclyn R. Patterson, Joseph E. Pero, Robert Sanchez, Matthew Robert Sender, Lamont Roscoe Terrell, David J. Behm, James V. Thomas
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Publication number: 20200071310Abstract: The present invention relates to N-aryl pyrazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.Type: ApplicationFiled: December 11, 2017Publication date: March 5, 2020Inventors: Brian W. BUDZIK, Peng LI, Joseph E. PERO, Charlotte Mary GRIFFITHS-JONES, Thomas Daniel HEIGHTMAN, David NORTON, Hendrika Maria Gerarda WILLEMS, Alison Jo-Anne WOOLFORD
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Publication number: 20200055863Abstract: The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example Alzheimer's disease.Type: ApplicationFiled: July 29, 2019Publication date: February 20, 2020Inventors: Zehong WAN, Xiaomin Zhang, Jian Wang, Matthew Robert Sender, Eric Steven Manas, Raphael Anthony Rivero, Joseph E. Pero, Christopher Ernst Neipp, Vipulkumar Kantibhai Patel
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Publication number: 20200031820Abstract: The present invention relates to 3-carboxylic acid pyrrole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.Type: ApplicationFiled: December 11, 2017Publication date: January 30, 2020Inventors: Brian W. BUDZIK, Peng LI, Joseph E. PERO, Charl mARY GRIFFITHS-JONES, Thomas Daniel HEIGHTMAN, Dvid NORTON, Hendrika Maria WILLEMS, Alison Jo-Anne WOOLFORD
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Patent number: 10442778Abstract: Disclosed are compounds of Formula A-1, or a salt thereof: Formula A-1, where J, K, Q and R1 are as defined herein, which compounds have properties for inhibiting sodium ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-1 or their salts, and methods of treating pain (e.g. chronic pain), or cough or itch disorders using the same.Type: GrantFiled: March 17, 2017Date of Patent: October 15, 2019Assignee: Merck Sharp & Dohme Corp.Inventors: Anthony J. Roecker, Mark E. Layton, Thomas J. Greshock, Joseph E. Pero, Michael J. Kelly, III, Ting Zhang
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Patent number: 10428078Abstract: The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example Alzheimer's disease.Type: GrantFiled: September 27, 2018Date of Patent: October 1, 2019Assignee: GlaxoSmithKline Intellectual Property Development LimitedInventors: Zehong Wan, Xiaomin Zhang, Jian Wang, Matthew Robert Sender, Eric Steven Manas, Raphael Anthony Rivero, Joseph E Pero, Christopher Ernst Neipp, Vipulkumar Kantibhai Patel
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Patent number: 10364256Abstract: The present invention relates to biaryl pyrazole compounds of Formula (I) methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.Type: GrantFiled: October 6, 2016Date of Patent: July 30, 2019Assignees: GlaxoSmithKline Intellectual Property Development Limited, Astex Therapeutics LimitedInventors: James Callahan, Jeffrey K. Kerns, Peng Li, Tindy Li, Brent W. McCleland, Hong Nie, Joseph E. Pero, Thomas Glanmor Davies, Maria Grazia Carr, Charlotte Mary Griffiths-Jones, Thomas Daniel Heightman, David Norton, Marinus Leendert Verdonk, Alison Jo-Anne Woolford, Hendrika Maria Gerarda Willems
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Publication number: 20190216774Abstract: The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.Type: ApplicationFiled: September 20, 2017Publication date: July 18, 2019Inventors: Edward J. BRNARDIC, Carl A. BROOKS, Brian Griffin LAWHORN, Guosen YE, Lisa S. BARTON, Brian W. BUDZIK, Jay M. MATTHEWS, John Jeffrey McATEE, Jacyln R. PATTERSON, Joseph E. PERO, Robert SANCHEZ, Matthew Robert SENDER, Lamont Roscoe TERRELL, David J. BEHM, James V. THOMAS
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Patent number: 10351530Abstract: The present invention relates to arylcyclohexyl pyrazole compounds of Formula (I) methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.Type: GrantFiled: October 6, 2016Date of Patent: July 16, 2019Assignees: GlaxoSmithKline Intellectual Property Development Limited, Astex Therapeutics LimitedInventors: James Callahan, Jeffrey K. Kerns, Tindy Li, Brent W. McCleland, Hong Nie, Joseph E. Pero, Thomas Glanmor Davies, Charlotte Mary Griffiths-Jones, Thomas Daniel Heightman, Steven Howard, David Norton, Marinus Leendert Verdonk, Alison Jo-Anne Woolford
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Publication number: 20190092738Abstract: Disclosed are compounds of Formula A-1, or a salt thereof: Formula A-1, where J, K, Q and R1 are as defined herein, which compounds have properties for inhibiting sodium ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-1 or their salts, and methods of treating pain (e.g. chronic pain), or cough or itch disorders using the same.Type: ApplicationFiled: March 17, 2017Publication date: March 28, 2019Applicant: Merck Sharp & Dohme Corp.Inventors: Anthony J. Roecker, Mark E. Layton, Thomas J. Greshock, Joseph E. Pero, Michael J. Kelly, III, Ting Zhang
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Publication number: 20190023715Abstract: The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example Alzheimer's disease.Type: ApplicationFiled: September 27, 2018Publication date: January 24, 2019Inventors: Zehong WAN, Xiaomin ZHANG, Jian WANG, Matthew Robert SENDER, Eric Steven MANAS, Raphael Anthony RIVERO, Joseph E PERO, Christopher Ernst NEIPP, Vipulkumar Kantibhai PATEL
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Patent number: 10125141Abstract: The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example Alzheimer's disease.Type: GrantFiled: July 21, 2015Date of Patent: November 13, 2018Assignee: GlaxoSmithKline Intellectual Property Development LimitedInventors: Zehong Wan, Xiaomin Zhang, Jian Wang, Matthew Robert Sender, Eric Steven Manas, Raphael Anthony Rivero, Joseph E Pero, Christopher Ernst Neipp, Vipulkumar Kantibhai Patel
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Publication number: 20180282349Abstract: The present invention relates to biaryl pyrazole compounds of Formula (I) methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.Type: ApplicationFiled: October 6, 2016Publication date: October 4, 2018Inventors: James CALLAHAN, Jeffrey K. KERNS, Peng LI, Tindy LI, Brent W. McCLELAND, Hong NIE, Joseph E. PERO, Thomas Glanmor DAVIES, Maria GRAZIA CARR, Charlotte Mary GRIFFITHS-JONES, Thomas Daniel HEIGHTMAN, David NORTON, Marinus Leedert VERDONK, Alison Jo-Anne WOOLFORD, Hendrika Maria Gerarda WILLEMS