Abstract: Polynucleotides and polypeptides useful in the manufacture of a class of chemical compounds known as alkaloids are provided. The polynucleotides and polypeptides may be used to synthesize alkaloids, including reticuline, thebaine and morphine, in vivo and in vitro. The polynucleotides further may be used to examine the presence of the polynucleotides in a cell or a cell extract, and to modulate expression thereof in living cells.

Abstract: Polynucleotides and polypeptides useful in the manufacture of a class of chemical compounds known as alkaloids are provided. The polynucleotides and polypeptides may be used to synthesize alkaloids, including reticuline, thebaine and morphine, in vivo and in vitro. The polynucleotides further may be used to examine the presence of the polynucleotides in a cell or a cell extract, and to modulate expression thereof in living cells.

Abstract: Disclosed herein are methods that may be used for the synthesis of benzylisoquinoline alkaloids (“BIAs”) such as alkaloid morphinan. The methods disclosed can be used to produce thebaine, oripavine, codeine, morphine, oxycodone, hydrocodone, oxymorphone, hydromorphone, naltrexone, naloxone, hydroxycodeinone, neopinone, and/or buprenorphine. Compositions and organisms useful for the synthesis of BIAs, including thebaine synthesis polypeptides, purine permeases, and polynucleotides encoding the same, are provided.

Abstract: Polynucleotides and polypeptides useful in the manufacture of a class of chemical compounds known as alkaloids are provided. The polynucleotides and polypeptides may be used to synthesize alkaloids, including reticuline, thebaine and morphine, in vivo and in vitro. The polynucleotides further may be used to examine the presence of the polynucleotides in a cell or a cell extract, and to modulate expression thereof in living cells.

Abstract: Described herein are methods for playing a rotation game on a pool table, and methods for scoring and racking rotation games described herein.

Abstract: Effective dosing regimens for neural stem cell proliferating and differentiating agents, kits comprising effective dosing regimens for neural stem cell proliferating and differentiating agents, and uses thereof are provided herein. Such kits and methods can be utilized acutely or chronically to treat a neurodegenerative disease or condition. Furthermore, the compositions and methods can be used continuously or intermittently in various dosing regimens.

Abstract: A method and apparatus for playing pool on a pool table is disclosed. A plurality of target raised pockets is located on the pool table and pool balls are hit into an indentation on the raised pocket. For example, a plurality of pool balls is arranged in a starting position on the playing surface of the pool table. Players alternate turns wherein each player attempts to hit balls from a set of pool balls assigned to that player onto the target raised pockets on the pool table using a pool cue. The game ends when the player has hit all of his assigned balls onto an indentation on a top level of the target raised pocket.

Abstract: A method and apparatus for playing pool on a pool table is disclosed. A raised stand is located on the pool table and pool balls are hit into an indentation on the raised stand. For example, a plurality of pool balls is arranged in a starting position on the playing surface of the pool table. The plurality of pool balls is comprised of an object ball and a plurality of different sets of pool balls. Players alternate turns wherein each player attempts to hit balls from a set of pool balls assigned to that player into pockets in the pool table using a pool cue and a cue ball.

Abstract: A billiards aiming and shot training device is disclosed. The device includes a hand grip having an index finger support, middle finger support and thumb support. Extending from the hand grip is a billiards cue supporting surface. The supporting surface has a channel surface that forms a trough sized and dimensioned to allow a shaft of a billiards cue to slide therein. The device may further include one or more forward facing sighting lasers to aid the billiards player in aligning a shot.

Abstract: Effective dosing regimens for neural stem cell proliferating and differentiating agents, kits comprising effective dosing regimens for neural stem cell proliferating and differentiating agents, and uses thereof are provided herein. Such kits and methods can be utilized acutely or chronically to treat a neurodegenerative disease or condition. Furthermore, the compositions and methods can be used continuously or intermittently in various dosing regimens.