Abstract: A device for radially compressing a stent includes a housing and a first iris including a first circumferential ring and a first plurality of arms extending inward from the ring, each arm defining a first outer hinge point and a first inner hinge point. Rotation of the ring in a first direction is configured to shift the inner hinge point from a first side to a second side of a first radius extending through a central longitudinal axis of the iris and the first outer hinge point. A radially outward force exerted against the arms biases the ring in a first direction in a first configuration and in a second direction in a second configuration. A method of loading a stent includes inserting a stent into the iris, and rotating the ring to shift the arms from the first to the second configuration.

Abstract: Provided herein are methods and compositions for trans-tympanic membrane delivery of therapeutic agents such as antimicrobial agents, anti-inflammatory agents, and anti-biofilm agents to the middle or inner ear for rapid, localized treatment and prevention of diseases and conditions associated with a middle ear infection. In particular, provided herein are anionic and polymer-based nanoparticles that provide a platform for delivery of therapeutic cargo, as well as anionic and polymer-based nanoparticle compositions for rapid, localized delivery of therapeutic agents to the middle or inner ear.

Abstract: A method, computer program product, and computer system for receiving, by a computing device, input data from a user participating in a simulation scenario. Input data from the simulation scenario may be received. An intervention event may be triggered in the simulation scenario based upon, at least in part, the input data from the user participating in the simulation scenario and the input data from the simulation scenario.

Abstract: A method, computer program product, and computer system for executing, by a computing device, a simulation scenario. Input data from a user participating in the simulation scenario may be received. Input data from the simulation scenario may be received. The input data from the user participating in the simulation scenario and the input data from the simulation scenario may be analyzed. Feedback may be provided to the user participating in the simulation scenario based upon, at least in part, analyzing the input data from the user participating in the simulation scenario and the input data from the simulation scenario.

Abstract: A method, computer program product, and computer system for receiving, by a computing device, input data from a user participating in a simulation scenario. Input data from a user participating in the simulation scenario may be received. Input data from the simulation scenario may be received, wherein the input data from the user participating in the simulation scenario and the input data from the simulation scenario may be processed using feature engineering data. Performance of the user in the simulation scenario may be predicted to generate a predicted performance of the user based upon, at least in part, the input data from the user participating in the simulation scenario and the input data from the simulation scenario processed using the artificial intelligence feature engineering model.

Abstract: A method, computer program product, and computer system for receiving, by a computing device, input data from a user participating in a live simulation scenario. Input data from the live operation may be received. The input data from the user participating in the live operation and the input data from the live operation may be analyzed. Feedback may be provided to the user participating in the live operation based upon, at least in part, analyzing the input data from the user participating in the live operation and the input data from the live operation.

Abstract: A method, computer program product, and computer system for receiving, by a computing device, input data from a user participating in a simulation scenario. Input data from the simulation scenario may be received. The simulation scenario may be monitored for one of a predicted performance of the user, the input data from the user participating in the simulation scenario, and the input data from the simulation scenario. One of the predicted performance of the user, the input data from the user participating in the simulation scenario, and the input data from the simulation scenario may be matched to a rule of a plurality of rules. An intervention event may be triggered in the simulation scenario based upon, at least in part, matching the one of the predicted performance of the user, the input data from the user participating in the simulation scenario, and the input data from the simulation scenario to the rule of the plurality of rules.

Abstract: A method, computer program product, and computer system for receiving, by a computing device, input data from a user participating in a simulation scenario, wherein the input data may include biometric data. Input data from the simulated scenario may be received. The biometric data of the user may be determined to be indicative of suboptimal performance in at least one parameter of the simulation scenario. An intervention event may be triggered in the simulation scenario based upon, at least in part, determining that the biometric data of the user is indicative of suboptimal performance in at least one parameter of the simulation scenario.

Abstract: Methods and equipment for the recycling of carpet are disclosed that produce a clean fiber product suitable for industrial use. The methods allow the recovery of face fiber material, for example a polyester, polyolefin, or a polyamide, from carpets that includes a face fiber material, a polypropylene backing material, and an adhesive, and include the steps of mechanically impacting the carpet to break the bonds between the adhesive and the fibrous components, treating the fibrous components to remove adhesive granules from the fibrous components, and optionally separating the polypropylene backing from the face fiber. A clean adhesive/calcium carbonate product can also be produced from this process.

Abstract: The invention provides anti-KLK7 antibodies, anti-KLK5 antibodies, anti-KLK5/KLK7 multispecific antibodies, and methods of using the same.

Abstract: The invention provides anti-KLK7 antibodies, anti-KLK5 antibodies, anti-KLK5/KLK7 multispecific antibodies, and methods of using the same.

Abstract: Methods of purifying proteins expressed in non-mammalian expression systems in a non-native soluble form directly from cell lysate are disclosed. Methods of purifying proteins expressed in non-mammalian expression systems in a non-native limited solubility form directly from a refold solution are also disclosed. Resin regeneration methods are also provided.

Abstract: Sulcardine salts other than sulfuric acid salts of sulcardine, including crystalline sulcardine salts, are provided herein. Pharmaceutical compositions comprising such salts and methods of treating arrhythmias comprising administering effective amounts of such salts are also provided.

Abstract: A testing apparatus for torque off weld stud testing has a socket to receive a weld stud welded to a metal sheet for testing strength of the weld. A stopper is received in the socket indexing the weld stud. A nut locks the stopper in position to enable repeated socket indexing to like weld studs.

Abstract: A cooking appliance includes a cooking cavity having first and second sidewalls that are spaced-apart from one another. A housing includes first and second sidewalls that are spaced-apart from one another and an upper wall. The first and second sidewalls of the housing are spaced-apart from the first and second sidewalls of the cooking cavity to define first and second side channels therebetween, respectively. A duct assembly includes first and second sidewalls spaced-apart from one another and an upper wall. The duct assembly is positioned on the upper wall of the housing and includes an interior cavity having a front opening and a rear opening. A blower assembly includes an inlet operably coupled to the rear opening of the duct assembly and is fluidically coupled to the first and second channels. The blower assembly includes an upwardly opening rear outlet having a plurality of baffles and deflectors positioned therein.

Abstract: Delivery devices for an occlusive implant and method for making and using delivery devices are disclosed. An example delivery device may include a delivery sheath having a proximal region, a distal tip region, and a lumen formed therein. A core wire may be slidably disposed in the lumen. The core wire may include a central shaft, a first region having a first coil assembly disposed along the central shaft, a second region having a second coil assembly disposed along the central shaft, and a distal implant securing region. An occlusive implant may be coupled to the distal implant securing region.

Abstract: The present disclosure describes an ultrasonic rotary molding system that is used to form edible compositions or food products as they move along a conveyor belt. The food products are formed by an ultrasonic rotary wheel that includes one or more cutting tools that cut, and perhaps three dimensionally mold, food product strips. The system may include a movable backing plate that is located below the point where the ultrasonic rotary wheel cuts the food product strips. The movable backing plate may be spring loaded and it may exert force upwards against the conveyor belt and in turn against the food product.

Abstract: Provided herein are methods and composition for trans-tympanic membrane delivery of therapeutic agents such as antimicrobial agents, anti-inflammatory agents, and anti-biofilm agents to the middle ear for rapid, localized treatment and prevention of diseases and conditions associated with a middle ear infection. In particular, provided herein are cationic, anionic, and polymer-based nanoparticles that provide a platform for delivery of therapeutic cargo, as well as cationic, anionic, and polymer-based nanoparticles compositions for rapid, localized delivery of therapeutic agents to the middle ear.

Abstract: This disclosure relates to methods and compositions for the treatment of thrombocytopenia.

Abstract: A method of refolding proteins expressed in non-mammalian cells present in concentrations of 2.0 g/L or higher is disclosed. The method comprises identifying the thiol pair ratio and the redox buffer strength to achieve conditions under which efficient folding at concentrations of 2.0 g/L or higher is achieved and can be employed over a range of volumes, including commercial scale.