Patents by Inventor Joseph F. Arboleda-Velasquez

Joseph F. Arboleda-Velasquez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TOPOTECAN FOR PROLIFERATIVE VITREORETINOPATHY
    Publication number: 20230355611
    Abstract: The use of topotecan, e.g., repeated dosing or sustained-release formulations of topotecan, for treating or reducing risk of proliferative vitreoretinopathy (PVR) or epiretinal membranes (ERM), e.g., after surgical vitrectomy to treat retinal detachment, is described herein.
    Type: Application
    Filed: March 30, 2023
    Publication date: November 9, 2023
    Inventors: Leo A. Kim, Joseph F. Arboleda-Velasquez, Dean Eliott, Elizabeth Jeffries Rossin
  • RHO KINASE INHIBITION FOR TREATMENT OF PROLIFERATIVE VITREORETINOPATHY AND CONDITIONS ASSOCIATED WITH EPITHELIAL TO MESENCHYMAL TRANSITION
    Publication number: 20230310446
    Abstract: The use of Rho Kinase (ROCK1/2) inhibitors for treating or reducing risk of proliferative vitreoretinopathy (PVR) or epiretinal membranes (ERM), e.g., after surgical vitrectomy to treat retinal detachment, and for treatment or reducing risk of conditions associated with epithelial to mesenchymal transition (EMT), including ocular fibrosis.
    Type: Application
    Filed: September 7, 2021
    Publication date: October 5, 2023
    Inventors: Leo A. Kim, Joseph F. Arboleda-Velasquez, Dhanesh Amarnani
  • NANO-EMULSION OF CBFß-RUNX1 INHIBITOR FOR OCULAR DRUG DELIVER
    Publication number: 20230277454
    Abstract: The invention provides ocular formulations and features a nano-emulsion composition, e.g., a nano-emulsion comprising a CBF?-RUNX1 inhibitor. The composition comprises a particle with a length of less than 200 nanometers in at least one dimension.
    Type: Application
    Filed: February 1, 2023
    Publication date: September 7, 2023
    Inventors: Leo A. Kim, Joseph F. Arboleda-Velasquez
  • RUNX1 inhibition for treatment of proliferative vitreoretinopathy and conditions associated with epithelial to mesenchymal transition
    Patent number: 11739326
    Abstract: The present subject matter provides compositions, formulations and methods for preventing or reducing proliferation or migration of retinal cells or epithelial to mesenchymal transition in ocular cells or cells from other tissues.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: August 29, 2023
    Assignees: Massachusetts Eye and Ear Infirmary, The Schepens Eye Research Institute, Inc.
    Inventors: Leo A. Kim, Joseph F. Arboleda-Velasquez, Dhanesh Amarnani, Dean Eliott
  • NUCLEIC ACID-BASED COMPOSITIONS AND METHODS FOR TREATING SMALL VESSEL DISEASES
    Publication number: 20230190959
    Abstract: The present subject matter provides, inter alia compositions, formulations, and methods for inhibiting, treating, and preventing small vessel diseases.
    Type: Application
    Filed: March 26, 2018
    Publication date: June 22, 2023
    Applicant: The Schepens Eye Research Institute, Inc.
    Inventor: Joseph F. Arboleda-Velasquez
  • Methods and Materials for Treatment of Fibrosis
    Publication number: 20230190764
    Abstract: Described herein are methods for treating and reducing risk of fibrosis, e.g., pulmonary fibrosis, in a subject by administering an inhibitor of RUNX family transcription factor 1 (RUNX1) or core-binding factor subunit beta (CBF?), e.g., in a subject who has a viral infection.
    Type: Application
    Filed: April 16, 2021
    Publication date: June 22, 2023
    Inventors: Joseph F. Arboleda-Velasquez, Leo A. Kim
  • NOTCH3 Agonist Compositions and Methods for Treating Small Vessel Diseases
    Publication number: 20230107235
    Abstract: The present subject matter provides, inter alia, compositions, formulations, and methods for inhibiting, treating, and preventing small vessel diseases.
    Type: Application
    Filed: August 31, 2022
    Publication date: April 6, 2023
    Inventor: Joseph F. Arboleda-Velasquez
  • Blood Biomarkers and Diagnostic Methods for Small Vessel Diseases
    Publication number: 20230078745
    Abstract: The present subject matter provides, inter alia, compositions, systems, kits, and methods for diagnosing and treating small vessel diseases (SVDs).
    Type: Application
    Filed: November 22, 2022
    Publication date: March 16, 2023
    Inventor: Joseph F. Arboleda-Velasquez
  • Nano-emulsion of CBFß-RUNX1 inhibitor for ocular drug delivery
    Patent number: 11583497
    Abstract: The invention provides ocular formulations and features a nano-emulsion composition, e.g., a nano-emulsion comprising a CBF?-RUNX1 inhibitor. The composition comprises a particle with a length of less than 200 nanometers in at least one dimension.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: February 21, 2023
    Assignee: The Schepens Eye Research Institute, Inc.
    Inventors: Leo A. Kim, Joseph F. Arboleda-Velasquez
  • NOTCH3 agonist compositions and methods for treating small vessel diseases
    Patent number: 11453718
    Abstract: The present subject matter provides, inter alia compositions, formulations, and methods for inhibiting, treating, and preventing small vessel diseases.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: September 27, 2022
    Assignee: The Schepens Eye Research Institute, Inc.
    Inventor: Joseph F. Arboleda-Velasquez
  • APOE ANTIBODIES, FUSION PROTEINS AND USES THEREOF
    Publication number: 20220227852
    Abstract: Methods and compositions for preventing or treating cognitive decline associated with dementia and/or mild cognitive impairment and/or neurodegeneration using antibodies, peptides, fusion proteins, or genome editing systems that modulate HSPG/heparin binding affinities of ApoE.
    Type: Application
    Filed: May 28, 2020
    Publication date: July 21, 2022
    Inventors: Yakeel T. Quiroz, Joseph F. Arboleda-Velasquez, Eric Reiman, Francisco Lopera
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF ABERRANT ANGIOGENESIS
    Publication number: 20220184109
    Abstract: The present subject matter provides compositions, formulations, and methods for inhibiting, treating, or preventing aberrant angiogenesis in a subject.
    Type: Application
    Filed: December 9, 2021
    Publication date: June 16, 2022
    Inventors: Joseph F. Arboleda-Velasquez, Leo A. Kim, Patricia A. D`Amore
  • Compositions and methods for the treatment of aberrant angiogenesis
    Patent number: 11229662
    Abstract: The present subject matter provides compositions, formulations, and methods for inhibiting, treating, or preventing aberrant angiogenesis in a subject.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: January 25, 2022
    Assignee: The Schepens Eye Research Institute, Inc.
    Inventors: Joseph F. Arboleda-Velasquez, Leo A. Kim, Patricia A. D'Amore
  • NANO-EMULSION OF CBFß-RUNX1 INHIBITOR FOR OCULAR DRUG DELIVERY
    Publication number: 20200375899
    Abstract: The invention provides ocular formulations and features a nano-emulsion composition, e.g., a nano-emulsion comprising a CBF?-RUNX1 inhibitor. The composition comprises a particle with a length of less than 200 nanometers in at least one dimension.
    Type: Application
    Filed: November 14, 2018
    Publication date: December 3, 2020
    Inventors: Leo A. Kim, Joseph F. Arboleda-Velasquez
  • RUNX1 INHIBITION FOR TREATMENT OF PROLIFERATIVE VITREORETINOPATHY AND CONDITIONS ASSOCIATED WITH EPITHELIAL TO MESENCHYMAL TRANSITION
    Publication number: 20200377888
    Abstract: The present subject matter provides compositions, formulations and methods for preventing or reducing proliferation or migration of retinal cells or epithelial to mesenchymal transition in ocular cells or cells from other tissues.
    Type: Application
    Filed: November 14, 2018
    Publication date: December 3, 2020
    Inventors: Leo A. Kim, Joseph F. Arboleda-Velasquez, Dhanesh Amarnani, Eliott Dean
  • NOTCH3 AGONIST COMPOSITIONS AND METHODS FOR TREATING SMALL VESSEL DISEASES
    Publication number: 20200102384
    Abstract: The present subject matter provides, inter alia compositions, formulations, and methods for inhibiting, treating, and preventing small vessel diseases.
    Type: Application
    Filed: March 26, 2018
    Publication date: April 2, 2020
    Applicant: The Schepens Eye Research Institute, Inc.
    Inventor: Joseph F. Arboleda-Velasquez
  • BLOOD BIOMARKERS AND DIAGNOSTIC METHODS FOR SMALL VESSEL DISEASES
    Publication number: 20200103419
    Abstract: The present subject matter provides, inter alia compositions, systems, kits and methods for diagnosing and treating small vessel diseases (SDVDs).
    Type: Application
    Filed: March 26, 2018
    Publication date: April 2, 2020
    Inventor: Joseph F. Arboleda-Velasquez
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF ABERRANT ANGIOGENESIS
    Publication number: 20190350961
    Abstract: The present subject matter provides compositions, formulations, and methods for inhibiting, treating, or preventing aberrant angiogenesis in a subject.
    Type: Application
    Filed: November 14, 2017
    Publication date: November 21, 2019
    Inventors: Joseph F. Arboleda-Velasquez, Leo A. Kim, Patricia A. D'Amore