Patents by Inventor Joseph F. Sambrook

Joseph F. Sambrook has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pai-1 mutants
    Patent number: 5866413
    Abstract: The present invention relates to serine protease mutants of the chymotrypsin superfamily that are resistant to inhibition by their cognate inhibitors, and genes that encode the same. The present invention also relates to serine protease inhibitor mutants that inhibit the serine protease mutants of the present invention, and genes that encode the same. The serine protease, mutants and serine protease inhibitor mutants are useful as, e.g., pharmacological agents.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: February 2, 1999
    Assignee: Board of Regents of the University of Texas System
    Inventors: Joseph F. Sambrook, Edwin L. Madison, Elizabeth J. Goldsmith, Maryjane H. Gething, Robert D. Gerard
  • U-PA mutants resistant to inhibition by their cognate inhibitors
    Patent number: 5728564
    Abstract: The present invention relates to serine protease mutants of the chymotrypsin superfamily that are resistant to inhibition by their cognate inhibitors, and genes that encode the same. The present invention also relates to serine protease inhibitor mutants that inhibit the serine protease mutants of the present invention, and genes that encode the same. The serine protease, mutants and serine protease inhibitor mutants are useful as, e.g., pharmacological agents.
    Type: Grant
    Filed: May 21, 1996
    Date of Patent: March 17, 1998
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Joseph F. Sambrook, Edwin L. Madison, Elizabeth J. Goldsmith, Maryjane H. Gething, Robert D. Gerard
  • Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors and genes encoding the same and serine protease inhibitor mutants and genes encoding the same
    Patent number: 5550042
    Abstract: The present invention relates to serine protease mutants of the chymotrypsin superfamily that are resistant to inhibition by their cognate inhibitors, and genes that encode the same. The present invention also relates to serine protease inhibitor mutants that inhibit the serine protease mutants of the present invention, and genes that encode the same. The serine protease, mutants and serine protease inhibitor mutants are useful as, e.g., pharmacological agents.
    Type: Grant
    Filed: November 13, 1989
    Date of Patent: August 27, 1996
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Joseph F. Sambrook, Edwin L. Madison, Elizabeth J. Goldsmith, Maryjane H. Gething, Robert D. Gerard
  • Genes encoding serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors
    Patent number: 5486602
    Abstract: The present invention relates to serine protease mutants of the chymotrypsin superfamily that are resistant to inhibition by their cognate inhibitors, and genes that encode the same. The present invention also relates to serine protease inhibitor mutants that inhibit the serine protease mutants of the present invention, and genes that encode the same. The serine protease mutants and serine protease inhibitor mutants are useful as, e.g., pharmacological agents.
    Type: Grant
    Filed: December 17, 1993
    Date of Patent: January 23, 1996
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Joseph F. Sambrook, Edwin L. Madison, Elizabeth J. Goldsmith, Maryjane H. Gething
  • Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors
    Patent number: 5304482
    Abstract: The present invention relates to serine protease mutants of the chymotrypsin superfamily that are resistant to inhibition by their cognate inhibitors, and genes that encode the same. The present invention also relates to serine protease inhibitor mutants that inhibit the serine protease mutants of the present invention, and genes that encode the same. The serine protease mutants and serine protease inhibitor mutants are useful as, e.g., pharmacological agents.
    Type: Grant
    Filed: September 28, 1990
    Date of Patent: April 19, 1994
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Joseph F. Sambrook, Edwin L. Madison, Elizabeth J. Goldsmith, Maryjane H. Gething
  • Method for identifying or shielding functional sites or epitopes of proteins that enter the exocytotic pathway of eukaryotic cells, the mutant proteins so produced and genes encoding said mutant proteins
    Patent number: 5041376
    Abstract: The present invention relates to a method for identifying or shielding functional sites or epitopes of proteins that enter the exocytotic pathway of eukaryotic cells (transportable proteins) by the addition of supernumerary N-linked oligosaccharide side chains at chosen sites on the surface thereof using oligonucleotide mutagenesis. The present invention also relates to mutant transportable proteins having supernumerary N-linked oligosaccharide side chains which shield functional sites or epitopes; and genes which encode the same.
    Type: Grant
    Filed: December 9, 1988
    Date of Patent: August 20, 1991
    Assignees: The Board of Regents of the University of Texas System, Cold Spring Harbor Laboratory
    Inventors: Mary J. Gething, Joseph F. Sambrook, Patricia Gallagher