Abstract: The present disclosure provides a method of treating cancer in a subject. The method including administering to the subject: a) a therapeutically effective amount of a compound of formula (I); and b) a therapeutically effective amount of nivolumab, wherein the compound of formula (I) is represented by formula (I) or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, conformational isomer, tautomer, or a combination thereof. In particular, the present disclosure provides a method of treating a solid tumor (e.g., an advanced non-small cell lung cancer) with a therapeutically effective amount of a compound of formula (10b) (i.e., 6-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-(Ra)-(2,3-dichlorophenyl)-2,5-dimethyl-4(3/7)-pyrimidinone) in combination with nivolumab in a subject, wherein the subject has one or more mutations in KRAS.

Abstract: A sphere brake system including a bracket (110) secured to a non-rotating component, a brake pad assembly (140) disposed externally to a spherical rotor (90), and an actuator (120) engagable with the brake pad assembly (140) to apply a force against the surface of the spherical rotor (90), where an axial face (114) of the bracket (110) includes an access window (130) located radially between the actuator (120) and the spherical rotor (90) and shaped to enable the brake pad assembly (140) to be inserted and removed, and where the brake pad assembly includes a friction pad (141), a backing plate (142), a spacer (150), and a retaining mechanism (160) that is securable to the bracket (110) or axially engageable against the actuator (120) to prevent axial movement relative to the actuator (120). Also, a corresponding sphere brake system brake pad assembly (140) for use with the sphere brake system.

Abstract: A cleaning apparatus and related system is disclosed where the cleaning apparatus includes a one or more grabber that is actuated by a one or more slider such that the cleaning apparatus is moveable between a closed position and an open position. By moving the cleaning apparatus into the open position, a user is able to place the apparatus over a pad. Moving the apparatus into a closed position while over the pad causes the grabber to pinch the pad to the base, thereby securing it to the apparatus. When the user wishes to discard the pad, the apparatus is moved from the closed position to the open position, releasing the pad.

Abstract: Disclosed herein are aspects of an inflatable packaging cushion. In one embodiment, the inflatable packaging cushion includes a body having at least one inflatable chamber. The body also includes a fluid port comprising an internal fluid passage that fluidly communicates with the at least one inflatable chamber such that the fluid port is configured to allow fluid to enter and exit the at least one inflatable chamber through the internal fluid passage for respective inflation and deflation of the at least one inflatable chamber. At least one elongate closure strip extends within the fluid passage of the fluid port. The at least one elongate closure strip is configured to be moved between a sealed position that closes the internal fluid passage and an unsealed position that opens the internal fluid passage.

Abstract: A towel system, assembly, and method enable a user to quickly identify, retrieve, and replace a moisture-absorbent medium. The towel system comprises, in combination, a circular towel, a support structure, and certain fastening structure. The towel is constructed from a moisture-absorbent medium and comprises a circular periphery, an anterior surface, and a posterior surface. The support structure comprises a vertical support surface. The fastening structure has a fastened thickness and is cooperable with the towel and the support surface for enabling a user to removably fasten the towel to the support surface. The fastening structure comprises towel-based and support-based structures. The fastening structure enables the user to removably fasten the towel adjacent the support surface a distance substantially equal to the fastened thickness for preventing contact between the towel and support surface and enabling the towel to hang within an air space surrounding the anterior and posterior surfaces.

Abstract: A system and method for automatically maximizing the quantity of a fluid which can be placed within a tank car having a maximum product weight based on the lesser of either an industry maximum product weight limit and a maximum calculated product weight at 2% outage is disclosed. The system includes a magnetostrictive probe having a movable float and a temperature gauge thereon and mounted within a tank car, such that the float is capable of being buoyed by a fluid. The system further includes a fluid pump capable of activation to transfer fluid from a bulk source to a tank car, and a controller coupled wirelessly to the magnetostrictive probe and an input device, and wired to one of either a fluid pump or shutoff valve, such that the maximum product weight is entered to the controller by the input device and the controller activates the pump or shutoff valve to begin addition of fluid to the tank car. A system monitor is coupled to the controller and wirelessly coupled to the magnetostrictive probe as well.

Abstract: A utility case for storage and transport of articles including a first storage compartment defined by a back wall, spaced side walls extending from laterally opposed margins of the back wall and a bottom wall extending between the side walls and contiguous with the back wall. A plurality of vertically offset holding units extend between and are supported by the side walls.

Abstract: A firearm carrying case includes a rigid outer housing and a flexible inner shell and pockets defined between the flexible inner shell and the outer housing. The outer housing includes a body having a contoured wall with an engagement portion, a chamber, and an open end. The open end is defined in a first plane. The outer housing also includes an end cap having a contoured wall an engagement portion, a chamber, and an open end. The end cap open end is defined in a second plane such that when the body and end cap are interconnected, an interior cavity is defined. The engagement portions interengage along a line of separation disposed oblique to the longitudinal axis, such that disconnection of the end cap from the body is easier. The flexible inner shell includes a soft wall defining an opening and an interior cavity for receiving the firearm. The inner shell is selectively, cooperatively and slidingly received within the chambers.

Abstract: A firearm carrying case includes a rigid outer housing and a flexible inner shell and pockets defined between the flexible inner shell and the outer housing. The outer housing includes a body having a contoured wall with an engagement portion, a chamber, and an open end. The open end is defined in a first plane. The outer housing also includes an end cap having a contoured wall an engagement portion, a chamber, and an open end. The end cap open end is defined in a second plane such that when the body and end cap are interconnected, an interior cavity is defined. The engagement portions interengage along a line of separation disposed oblique to the longitudinal axis, such that disconnection of the end cap from the body is easier. The flexible inner shell includes a soft wall defining an opening and an interior cavity for receiving the firearm. The inner shell is selectively, cooperatively and slidingly received within the chambers.

Abstract: A storage and carry wrap for a plurality of storage containers of relatively rigid material comprises a generally rectangularly shaped base panel having an inner face, an outer face, and opposed ends. A handle is affixed to the base panel midway between the ends. A plurality of pockets or receptacles are affixed to the base panel and are longitudinally disposed along the inner face thereof for releasably receiving the containers. The portions of the base panel on each side of the handle are foldable along spaced-apart transversely extending fold lines to each assume a generally U-shaped configuration with the receptacles being disposed in confronting relation. A cover affixed to the base panel proximal the handle includes first and second cover panel sections extending in opposite directions from the handle, and connects to the base panel portions when folded in their U-shaped configuration.

Abstract: A foldable ladder of the type having laterally spaced-apart, substantially vertically oriented front side rails joined by a plurality of steps. A rear support, preferably in the form of laterally spaced-apart, vertically oriented legs, are movable away from the side rails to open the ladder and movable toward the side rails to close the ladder. The side rails and rear legs include hinges intermediate vertical ends thereof for permitting vertical collapsing of the ladder by the folding of the side rails and rear legs about their respective hinges. A storage container, which also doubles as an article support when the ladder is used, also forms a part of the instant invention.

Abstract: A method and device for testing the pressure readings obtained by a pressure sensing blood vessel catheter connected to a transducer and bedside monitor. The device includes a syringe which connects with a tube to provide an airtight test chamber. The pressure sensing end of the catheter can be inserted using sterile techniques into the test chamber through a tapered passage formed through a diaphragm on the end of the tube. A plunger can be extended into the syringe barrel to apply pressure to the test chamber. The pressure that it is applied to the catheter end is indicated on a calibrated scale imprinted on the syringe barrel for comparison with the pressure readings on the bedside monitor.