Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract: Methods, systems, and devices for wireless communications are described. A user equipment (UE) may receive an indication of a positioning reference signal configuration of a base station. The UE may determine, based on the positioning reference signal configuration, a reference point within a carrier bandwidth of a component carrier and a frequency domain allocation for a positioning reference signal relative to the reference point. The UE may transmit the positioning reference signal or measure the positioning reference signal based on the frequency domain allocation.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: The present invention relates to compositions for the prolonged preservation and maintenance of living and static biological material, methods of making and uses thereof.

Abstract: In some examples, a computing device determines a data manipulation from a job specification. The device determines a corresponding data-processing instruction using data-source metadata, and determines and executes a corresponding query. In some examples, a device receives search keys. The device searches data-source metadata using the search keys. The device weights a first data source based on producer-consumer relationships between data sources, and ranks the first data source using the weight. In some examples, a device determines structural and content information of a data record. The device determines a data-source identifier from the structural information and stores the content information with the data-source identifier in a database. In some examples, via a user interface, a device receives a job specification and annotation data. The device stores the spec and the annotation data in a metadata repository.

Abstract: Data assets, such as streams, databases, spreadsheets, or other data sources or types, are identified and representations of the data asset are stored. The representation of a data asset includes a schema used by the data asset, a location of the data asset, and keywords or other descriptive information. The representations of each data asset are indexed, and a search interface is provided that allows users to search for relevant data assets. In addition, dependencies, or other relationship information, among the various data assets is maintained and is used to generate a graph that shows the interrelatedness of the data assets. The graph can be explored by users to select data assets, and used to alert users when a change has been made to a data asset that may affect a data asset that they have used.

Abstract: Data assets, such as streams, databases, spreadsheets, or other data sources or types, are identified and representations of the data asset are stored. The representation of a data asset includes a schema used by the data asset, a location of the data asset, and keywords or other descriptive information. The representations of each data asset are indexed, and a search interface is provided that allows users to search for relevant data assets. In addition, dependencies, or other relationship information, among the various data assets is maintained and is used to generate a graph that shows the interrelatedness of the data assets. The graph can be explored by users to select data assets, and used to alert users when a change has been made to a data asset that may affect a data asset that they have used.

Abstract: In some examples, a computing device determines a data manipulation from a job specification. The device determines a corresponding data-processing instruction using data-source metadata, and determines and executes a corresponding query. In some examples, a device receives search keys. The device searches data-source metadata using the search keys. The device weights a first data source based on producer-consumer relationships between data sources, and ranks the first data source using the weight. In some examples, a device determines structural and content information of a data record. The device determines a data-source identifier from the structural information and stores the content information with the data-source identifier in a database. In some examples, via a user interface, a device receives a job specification and annotation data. The device stores the spec and the annotation data in a metadata repository.

Abstract: Many current computer software platforms support user customization and version upgradability. Unfortunately, upgrading a computer software platform may result in significant loss of user customization data. Additionally, it may be advantageous for users to export and import their customization data to share as customized business solutions with other instances of the computer software platforms. Accordingly, a technique for creating and importing a configuration package and a technique for creating and utilizing an update package is disclosed herein. The configuration package allows configuration data of elements within a computer software platform to be exported and imported. The update package allows elements to be exported within the update package. The update package may be utilized in upgrading, overwriting, and/or creating a new instance of elements. When an existing element is upgraded with an update element within the update package, the existing element's original configuration may be retained.

Abstract: Many current computer software platforms support user customization and version upgradability. Unfortunately, upgrading a computer software platform may result in significant loss of user customization data. Additionally, it may be advantageous for users to export and import their customization data to share as customized business solutions with other instances of the computer software platforms. Accordingly, a technique for creating and importing a configuration package and a technique for creating and utilizing an update package is disclosed herein. The configuration package allows configuration data of elements within a computer software platform to be exported and imported. The update package allows elements to be exported within the update package. The update package may be utilized in upgrading, overwriting, and/or creating a new instance of elements. When an existing element is upgraded with an update element within the update package, the existing element's original configuration may be retained.

Abstract: The present invention relates to a method for storing cells, wherein the cells are stored in a composition comprising a base nutritive medium and liposomes at temperatures in the range of ?196° C. to 37° C., characterized in that the liposomes comprise one or more sterols and that the cells are tumor cells. More specifically, the invention relates to simple and effective methods for storing tumor cells, wherein the RNA and/or DNA in the cells is essentially not degraded, such that the RNA and/or DNA can be analyzed after storage.

Abstract: The present invention is directed to methods of preserving mammalian heart, ex vivo. Nanoparticle compositions for carrying out the invention are also disclosed.

Abstract: A method for aligning investor and portfolio manager interest comprising a polyfunctional fee algorithm. wherein said algorithm charges higher fees to the investor when returns are favorable and charges a lower fees to the investor when returns are not favorable.

Abstract: Bucket tip tenons requiring refurbishment are removed from the bucket tips by grinding. Groups of buckets are clamped on a rotatable table in positions adjacent an induction heating coil and a robotic welding arm, respectively. While one group is preheated, the other group of buckets is in a welding location, enabling the welding head on the robotic arm to sequentially apply weld buildup material to the bucket tips. After applying weld buildup material in multiple passes and sequentially to the bucket tips, the buckets are removed, stress-relieved and the weld buildup material machined to provide refurbished tenons. Upon removal of the buckets from the table, the table is rotated to locate the preheated buckets in welding locations and additional buckets are clamped to the table for preheating.

Abstract: The present invention is directed to methods of preserving mammalian heart, ex vivo. Nanoparticle compositions for carrying out the invention are also disclosed.

Abstract: The present invention is directed to nanoparticle compositions for maintaining organ, tissue and cellular viability when such are separated from normal physiological supports. Compositions containing the nanoparticle compositions and methods of preserving organs such as kidneys, both in vivo and ex vivo, are also disclosed.

Abstract: The present invention relates to a method for storing cells, wherein the cells are stored in a composition comprising a base nutritive medium and liposomes at temperatures in the range of ?196° C. to 37° C., characterized in that the liposomes comprise one or more sterols and that the cells are tumor cells. More specifically, the invention relates to simple and effective methods for storing tumor cells, wherein the RNA and/or DNA in the cells is essentially not degraded, such that the RNA and/or DNA can be analyzed after storage.