Abstract: Provided herein are methods, compositions, and kits for preparing biological samples for multiplex spatial gene expression and proteomic analysis, such as determining a location of a nucleic acid analyte and a protein analyte in a biological sample.

Abstract: The disclosure provides systems, devices, and associated methods for mitigating traumatic brain injury, injury to an ocular structure, or injury to the inner ear of a subject by applying pressure to one or more neck veins before and during an injurious event.

Abstract: Inhibitors against SARS-COV-1, SARS-CoV-2 (Covid-19), MERS-CoV, and variants within each, including methods of treating a subject suffering from such respiratory disease.

Abstract: A process control system (PCS) includes a cable connection including physical cables including a first cable for connecting between a process controller and an I/O access device, and an independent second cable for connecting the process controller and a second node being the I/O access device or another device. The I/O access device is for coupling to I/O module(s) to receive an output of the I/O access device. An output of the I/O module is coupled to a field device coupled to processing equipment. The process controller and I/O access device each include a processor and memory that implement send and receive logic for communicating using any of multiple redundancy protocols including a first and a second redundant protocol. The cable connection is for supporting simultaneously communicating between the process controller and the second node utilizing both the first redundant protocol and the second redundant protocol.

Abstract: A static random-access memory is set forth comprising: a word line circuit for generating a word line signal on a word line; a plurality of six-transistor memory cells arranged between a first bitline, a second bitline and the word line for simultaneously selecting one of either all or a portion of the plurality of six-transistor memory cells for data reading or writing, and wherein each memory cell includes first and second n-channel transistors and a bitline precharge circuit for precharging the first bitline and second bitline to a voltage of Vdd/2 prior to the first and second n-channel transistors receiving the word line signal.

Abstract: Computer systems and methods are provided for compiling a computer program to run on a quantum processor comprising a plurality of qubits, qudits or quantum continuous variables. A compiler obtains the program in a unified language, that is effectively a classical language, as opposed to a quantum language, and performs code refactoring on all or a portion of the program to form a refactored code and converts the refactored code into a first code. The compiler compiles the first code into a second code comprising a plurality of data elements in one or more quantum data structures. The compiler converts the second code to a third code expressed in a quantum gate-level language in accordance with an instruction set and gate locality constraints of the target quantum processor.

Abstract: An electrical conductor assembly for use in a power distribution assembly includes an electrical conductor and a casing covering at least a portion of the electrical conductor. A spring member is mounted to the casing and configured to apply a compressive force to the electrical conductor.

Abstract: A circuit comprises an amplifier network including a first amplifier and a second amplifier and a first transistor having a first base. The first transistor is thermally isolated from the second amplifier. The circuit further comprises a second transistor having a second base. The second transistor is thermally linked to the second amplifier. The circuit further comprises coupling circuitry configured to couple the first base to the second base.

Abstract: Method for reducing intake valve deposits in a spark ignition internal combustion engine which is fuelled with a gasoline fuel composition, wherein the method comprises introducing into the engine an aqueous based composition, wherein the aqueous based composition comprises (i) water, (ii) from 0 vol % to 40 vol % freezing point suppression agent, (iii) from 0 vol % to 10 vol % of surfactant, and (iv) an amine compound in a blending amount of from 0 ppmw to 1000 ppmw.

Abstract: Provided is a system and method for determining an appropriate dosage of a product. The method includes, receiving from a User a User Request for a Dosage, the User Request including at least a User Reason and a User Location; accessing a Database of Products, each Product having at least one Constituent, at least one Established Reason, a Dosage for each Established Reason, and Provider Location; querying the Database of Products with the User Request to determine at least a first subset of Products having the at least one Established Reason correlating to the User Reason; and providing the User with the first subset of Products arranged by proximity of the Provider Location to the User Location, the first subset of Products further including the Dosage for each Product in the first subset of Products. An associated system is also provided.

Abstract: The present disclosure provides systems and methods for making a hydrogel comprising a cell, cell nucleus, or one or more components derived from a cell or cell nucleus. A method for making a hydrogel may comprise providing a cell or cell nucleus, a first polymer, wherein the first polymer comprises a plurality of first crosslink precursors, each of the plurality of first crosslink precursors comprising an azide group; providing a second polymer, wherein the second polymer comprises a plurality of second crosslink precursors, each of the plurality of second crosslink precursors comprising an alkyne group; and crosslinking the first polymer and the second polymer via a reaction between a first section of the first crosslink precursors and a second section of the second crosslink precursors, thereby providing the hydrogel comprising the cell or cell nucleus.

Abstract: A static random-access memory is set forth comprising: a word line circuit for generating a word line signal on a word line; a plurality of six-transistor memory cells arranged between a first bitline, a second bitline and the word line for simultaneously selecting one of either all or a portion of the plurality of six-transistor memory cells for data reading or writing, and wherein each memory cell includes first and second n-channel transistors and a bitline precharge circuit for precharging the first bitline and second bitline to a voltage of Vdd/2 prior to the first and second n-channel transistors receiving the word line signal.

Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.

Abstract: Provided herein are methods, compositions, and kits for preparing biological samples for multiplex spatial gene expression and proteomic analysis, such as determining a location of a nucleic acid analyte and a protein analyte in a biological sample.

Abstract: Light detection devices and related methods are provided. The devices may comprise a reaction structure for containing a reaction solution with a relatively high or low pH and a plurality of reaction sites that generate light emissions. The devices may comprise a device base comprising a plurality of light sensors, device circuitry coupled to the light sensors, and a plurality of light guides that block excitation light but permit the light emissions to pass to a light sensor. The device base may also include a shield layer extending about each light guide between each light guide and the device circuitry, and a protection layer that is chemically inert with respect to the reaction solution extending about each light guide between each light guide and the shield layer. The protection layer prevents reaction solution that passes through the reaction structure and the light guide from interacting with the device circuitry.

Abstract: A static random-access memory is set forth comprising: a word line circuit for generating a word line signal on a word line; a plurality of six-transistor memory cells arranged between a first bitline, a second bitline and the word line for simultaneously selecting one of either all or a portion of the plurality of six-transistor memory cells for data reading or writing, and wherein each memory cell includes first and second n-channel transistors and a bitline precharge circuit for precharging the first bitline and second bitline to a voltage of Vdd/2 prior to the first and second n-channel transistors receiving the word line signal.

Abstract: Computer systems and methods are provided for compiling a computer program to run on a quantum processor comprising a plurality of qubits, qudits or quantum continuous variables. A compiler obtains the program in a unified language, that is effectively a classical language, as opposed to a quantum language, and performs code refactoring on all or a portion of the program to form a refactored code and converts the refactored code into a first code. The compiler compiles the first code into a second code comprising a plurality of data elements in one or more quantum data structures. The compiler converts the second code to a third code expressed in a quantum gate-level language in accordance with an instruction set and gate locality constraints of the target quantum processor.

Abstract: A method, a system, and a computer program product for detecting a diverse set of rare behavior. A time-series data representing one or more actions executed by an entity is received from a plurality of time-series data sources and is processed. A data structure corresponding to the entity, identifying the entity, and including one or more representations of processed time-series data identifying the actions is generated. A current action executed by the entity is detected. Current time-series data corresponding to the current action is received and associated with the data structure. First features are extracted from the generated data structure based on current time-series data and compared to second features extracted for at least another entity to determine difference parameters between first and second features. One or more models are trained using difference parameters, and a score for each action executed by the entity is determined.

Abstract: A system and method for a bicycle transmission. Specifically, a bicycle transmission having a housing with a first shaft passing therethrough and a set of two cones in opposing parallel alignment disposed within the housing. The first cone engaged about the first shaft, the second cone engaged about a second shaft parallel to the first shaft, the second shaft structured and arranged to have at least a proximal position and a distal position relative to the first shaft. A driver is disposed generally normally about one of the two cones and passing therebetween, the driver structured and arranged to engaging a portion of the first cone with a portion of the second cone when the second cone is in the proximal position. A driver mover structured and arranged to move the driver between the cones when the second cone is in the distal position; and a transfer element joined to an end of the second shaft.

Abstract: The present disclosure relates to a method of making a lensed connector in which a glass ferrule has holes within the body of the glass ferrule, and the glass ferrule is subsequently processed to form lens structures along the ferrule.