Abstract: Inhibitors of CDK9 that are pyrazolo[1,5-a]pyrimidine derivatives and salts thereof, corresponding to formula (I):

Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

Abstract: Consistent with the present disclosure, a local oscillator is provided in a receiver. The local oscillator laser a first and second mirrors and phase section and heaters are provided adjacent each portion of the laser, such that the temperature and thus the frequency of light output from the local oscillator laser may be tuned. Applying electrical power, such as a current or voltage to the phase section may result in rapid frequency tuning of light output from the local oscillator laser but over a limited frequency range. Temperature changes to the mirror sections, however, may afford frequency tuning over a wider range, but frequency tuning the mirror sections requires more time than that required to tune the phase section. Consistent with the present disclosure, a tuning method and apparatus is provided that optimizes laser tuning by selectively tuning the phase and mirror sections.

Abstract: Detecting fraudulent activity can be a complex, manual process. In this paper, we adapt statistical properties of count data in a novel algorithm to uncover records exhibiting high risk for fraud. Our method identifies shelves, partitioning data under the counts using a Student's t-distribution. We apply this methodology on a univariate dataset including cumulative results from phone calls to a customer service center. Additionally, we extend this technique to multivariate data, illustrating that the same method is applicable to both univariate and multivariate data.

Abstract: Systems and methods for enabling communication in a downhole power and communications system installed in a well, where one or more components of a wired backbone of the system have failed. Equipment positioned at the surface of a well is connected to a wired power and communication backbone that has one or more conductors and one or more nodes with standardized interfaces that enable downhole devices to be interchangeably connected to the wired backbone. When the wired backbone has failed at one or more points, preventing wired communications between the surface equipment and one or more downhole devices installed at the nodes, one or more wireless-enabled modules are installed at corresponding nodes of the wired backbone to establish wireless channels that bridge the failed portion of the wired backbone and thereby enable communication between the surface equipment and the downhole devices.

Abstract: Systems, methods, and materials are described for making solid unit dosage forms for administration of therapeutic and biotherapeutic agents, particularly dosage forms for various enteral, nasal, pulmonary, vaginal, topical, and other suitable non-injection delivery routes. Contact freezing methods may be used in conjunction with lyophilization or vacuum drying to process a liquid formulation and produce solid unit dosage forms having a high degree of structural stability while preserving the therapeutic activity of the included agents.

Abstract: A UI for presenting and reviewing a document is optimized based upon the type of computing device being utilized to present the document. One such UI includes a first pane showing a view of the document under review that is sized and formatted for display on a large-format display device. The first pane can also be utilized to emphasize a portion of the document. The UI also includes a second pane that includes indicators for each of the reviewers of the document. The selection of an indicator will cause a portion of the document being reviewed by the corresponding reviewer to be displayed in the first pane. The UI also includes a third pane that includes a scaled image of the document shown in the first pane. Selection of a portion of the scaled image causes the selected portion of the document to be displayed in the first pane.

Abstract: A liner for a combustor includes a support member, an intermediate member, and a liner member. The intermediate member is positioned intermediate the support member and the liner member and has a plurality of protrusions and a plurality of recesses. The support member is coupled to the intermediate member at a tangent of each protrusion. Additionally, the liner member is comprised of a ceramic matrix composite material. The liner member is coupled to the intermediate member at a tangent of each recess.

Abstract: An compact instrumented downhole coupling that includes a carrier and a set of sensors and electronics that are installed within the carrier. The carrier is a tubular structure having couplings at each end and a bore extending through the carrier from the first end to the second end, forming a carrier wall between the bore and the exterior surface of the carrier. The bore and couplings are offset from a central axis of the carrier (the axis of the cylindrical outer surface of the carrier), resulting in a thicker portion of the carrier wall on one side of the carrier. Cavities are formed (e.g., by drilling holes) within the thicker portion of the carrier wall. One or more sensors and corresponding electronics are then positioned within the cavities, so that the carrier wall itself forms a housing for the sensors and electronics.

Abstract: An apparatus for applying a magnetic pressure to a work piece includes an inductor configured to be disposed in proximity to the work piece and a controller electrically connected to the inductor and configured to control a supply of electrical power in order to output a first voltage over a selected frequency range to determine a frequency that provides a maximum current or a frequency that provides a current within a selected range of the maximum current to the inductor.

Abstract: An compact instrumented downhole coupling that includes a carrier and a set of sensors and electronics that are installed within the carrier. The carrier is a tubular structure having couplings at each end and a bore extending through the carrier from the first end to the second end, forming a carrier wall between the bore and the exterior surface of the carrier. The bore and couplings are offset from a central axis of the carrier (the axis of the cylindrical outer surface of the carrier), resulting in a thicker portion of the carrier wall on one side of the carrier. Cavities are formed (e.g., by drilling holes) within the thicker portion of the carrier wall. One or more sensors and corresponding electronics are then positioned within the cavities, so that the carrier wall itself forms a housing for the sensors and electronics.

Abstract: An apparatus for applying a magnetic pressure to a work piece includes an inductor configured to be disposed in proximity to the work piece and a controller electrically connected to the inductor and configured to control a supply of electrical power in order to output a first voltage over a selected frequency range to determine a frequency that provides a maximum current or a frequency that provides a current within a selected range of the maximum current to the inductor.

Abstract: An apparatus for applying a magnetic pressure to a work piece includes an inductor configured to be disposed in proximity to the work piece and a controller electrically connected to the inductor. The controller is configured to control a supply of electrical power in order to output a first voltage over a selected frequency range to determine a first frequency that provides a maximum current to the inductor or a second frequency that provides a current within a selected range of the maximum current to the inductor.

Abstract: A signal transmission system including a first transducer mounted to a surface of a member, a second transducer movable into contact with a second surface of the member, a material disposed between the second transducer and the second surface of the member. A method for communicating acoustic energy through a member including pressing a second transducer to a second surface of the member, the member having a first transducer mounted to an opposite surface thereof, sandwiching a material between the second transducer and the second surface of the member, and transmitting a signal between the first transducer and the second transducer.

Abstract: An apparatus for deploying one or more components of a borehole monitoring system includes a conductor assembly having one or more communication devices connected along a length of a conductor, each communication device being configured to wirelessly communicate data and/or power, the conductor configured to transmit the data and/or the power through a borehole in an earth formation. The apparatus further includes a deployment device configured to transport and support the length of the conductor having the one or more communication devices connected along the length of the conductor and deploy the length of the conductor in the borehole.

Abstract: A blade track assembly is disclosed having a variety of features. The assembly can have annular or segmented components, or a combination of the two. In one form the assembly includes blade tracks having a forward and aft edge that can be received in an opening of respective hangers. The hangers can include anti-movement features to discourage movement of a blade track. A rib can extend between hangers and in one form can be used as part of a seal assembly. Clips can be used to secure the blade track in openings of the respective hangers, as well as to discourage movement of the blade track.

Abstract: An annular assembly for a gas turbine engine and a method of making the annular assembly. The annular assembly comprises a supporting member comprising metal and including a support hole therethrough, and a liner tile made of ceramic matrix composite material. A plurality of the liner tile form an annular liner to shield hot combustion gases produced by the gas turbine engine. The liner tile is disposed adjacent the supporting member. A connecting member comprising ceramic material has a base element and a stem. The base element is embedded in the liner tile during construction of the liner tile to form an integrated structure therewith. A distal end of the stem passes through the support hole and is mated with a retaining member to retain the liner tile adjacent the supporting member.

Abstract: A seal segment for a gas turbine engine has a radially outer wall with a first length, a radially inner wall with a second length, and a rib member which extends radially between the outer wall and the inner wall and along the first and second lengths.

Abstract: A method for installing a tool in a downhole system including running the tool to a target location within a tubular structure, creating a magnetic pulse, and urging the tool toward the tubular structure at a minimum velocity of 200 meters per second with the magnetic pulse. A method for actuating a downhole tool including creating a magnetic pulse, coupling the magnetic pulse to a workpiece and moving the workpiece with the pulse, the workpiece achieving a minimum velocity of 200 meters per second.

Abstract: Systems and methods for enabling communication in a downhole power and communications system installed in a well, where one or more components of a wired backbone of the system have failed. Equipment positioned at the surface of a well is connected to a wired power and communication backbone that has one or more conductors and one or more nodes with standardized interfaces that enable downhole devices to be interchangeably connected to the wired backbone. When the wired backbone has failed at one or more points, preventing wired communications between the surface equipment and one or more downhole devices installed at the nodes, one or more wireless-enabled modules are installed at corresponding nodes of the wired backbone to establish wireless channels that bridge the failed portion of the wired backbone and thereby enable communication between the surface equipment and the downhole devices.