Patents by Inventor Joseph FREZZO

Joseph FREZZO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein polymer gold nanoparticle hybrid materials for small molecule delivery
    Patent number: 10463752
    Abstract: Protein polymer-gold nanoparticles, compositions comprising protein polymer-gold nanoparticles, and uses of protein polymer-gold nanoparticles. A protein polymer-gold nanoparticle comprises a gold core and a plurality of protein polymer molecules coordinated to the gold core via a poly-histidine tag present on each protein polymer molecule. A protein polymer molecule comprises one or more elastin-like polypeptide domain and a coiled-coil region of Cartilage Oligomeric Matrix Protein domain or a variant thereof. For example, the protein polymer-gold nanoparticles can be used in methods of small molecule delivery to an individual.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: November 5, 2019
    Assignee: New York University
    Inventors: Jin Kim Montclare, Joseph Frezzo, Min Dai, Raymond Chen
  • PROTEIN POLYMER GOLD NANOPARTICLE HYBRID MATERIALS FOR SMALL MOLECULE DELIVERY
    Publication number: 20170196984
    Abstract: Protein polymer-gold nanoparticles, compositions comprising protein polymer-gold nanoparticles, and uses of protein polymer-gold nanoparticles. A protein polymer-gold nanoparticle comprises a gold core and a plurality of protein polymer molecules coordinated to the gold core via a poly-histidine tag present on each protein polymer molecule. A protein polymer molecule comprises one or more elastin-like polypeptide domain and a coiled-coil region of Cartilage Oligomeric Matrix Protein domain or a variant thereof. For example, the protein polymer-gold nanoparticles can be used in methods of small molecule delivery to an individual.
    Type: Application
    Filed: January 6, 2017
    Publication date: July 13, 2017
    Inventors: Jin Kim Montclare, Joseph Frezzo, Min Dai, Raymond Chen
  • Protein engineered systems for delivery of molecules
    Patent number: 9453060
    Abstract: Provided are compositions and methods for efficient delivery of polynucleotides and/or small molecules to or into cells. The compositions comprises a peptide which as an excess positive charge and self assembles into homopentamers. The homopentamers can non-covalently bind polynucleotides. When encapsulated in lipid systems, such as liposomes, the lipoproteoplexes so formed, are capable of delivering both nucleic acids and small molecules to cells.
    Type: Grant
    Filed: August 11, 2014
    Date of Patent: September 27, 2016
    Assignee: New York University
    Inventors: Jin Kim Montclare, Haresh T. More, Joseph Frezzo, Carlo Yuvienco
  • PROTEIN ENGINEERED SYSTEMS FOR DELIVERY OF MOLECULES
    Publication number: 20160185834
    Abstract: Provided are compositions and methods for efficient delivery of polynucleotides and/or small molecules to or into cells. The compositions comprises a peptide which as an excess positive charge and self assembles into homopentamers. The homopentamers can non-covalently bind polynucleotides. When encapsulated in lipid systems, such as liposomes, the lipoproteoplexes so formed, are capable of delivering both nucleic acids and small molecules to cells.
    Type: Application
    Filed: August 11, 2014
    Publication date: June 30, 2016
    Inventors: Jin Kim MONTCLARE, Haresh T. MORE, Joseph FREZZO, Carlo YUVIENCO