Abstract: The disclosure features macrocyclic compounds, alone and in combination with other therapeutic agents, as well as pharmaceutical compositions and protein complexes thereof, capable of modulating biological processes including RAS and RAS-RAF inhibition, and their uses in the treatment of cancers.

Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

Abstract: An engagement part of a tool such as a hydraulic wrench (10), the engagement part (1) such as a ratchet link being arranged to engage a workpiece and a power head (11), the engagement part (1) being arranged to convert movement generated by the power head (11) into movement of the workpiece, the engagement part (1) comprising a mounting for the power head (4, 14), the mounting (4, 14) comprising a moveable portion moveable (4) from a first position where the power head (11) is fixed relative to the engagement part (1) and a second position where the power head (11) can move relative to the engagement part (1), the moveable portion (4) comprising a pin having a length and slidable along its length in a bore (17) in the engagement part (1) and a friction lock (2, 3) comprising a compressible member (3) and a compressing member (2) arranged to compress the compressible member (3), the compressible member (3) being arranged such that it expands in at least one extent on compression by the compressing member (2) s

Abstract: Various embodiments disclosed relate to an implant. The implant includes a substrate. The implant further includes a monolithic layer comprising a biocompatible metallic material, having at least one of an amorphous and a crystalline microstructure contacting the substrate.

Abstract: Various embodiments disclosed relate to an implant. The implant includes a substrate. The implant further includes a monolithic layer comprising a biocompatible metallic material, having at least one of an amorphous and a crystalline microstructure contacting the substrate.

Abstract: Example stands for supporting a component, such as a rotor blade, are described herein. An example stand described herein includes a blade support having an opening extending from an edge of the blade support towards a center of the blade support. The opening is to receive a rotor blade of an aircraft, for example. The example stand also includes a base to support the blade support above a supporting surface. The blade support is rotatably coupled to the base about a horizontal axis perpendicular to a central axis of the blade support such that the blade support can tilt the rotor blade relative to the supporting surface.

Abstract: Example stands for supporting a component, such as a rotor blade, are described herein. An example stand described herein includes a blade support having an opening extending from an edge of the blade support towards a center of the blade support. The opening is to receive a rotor blade of an aircraft, for example. The example stand also includes a base to support the blade support above a supporting surface. The blade support is rotatably coupled to the base about a horizontal axis perpendicular to a central axis of the blade support such that the blade support can tilt the rotor blade relative to the supporting surface.

Abstract: An enclosure for carrying an adjustable payload. The enclosure is beneficially used on a rotorcraft blade or other similar structure. The enclosure has a first element having a first flange and an upper element. The first element has an upper surface which has a first angle with respect to a lower surface of the first flange in a direction extending from an inboard direction to an outboard direction. The upper element has a lower surface which has a second angle with respect to an upper surface of said upper element in a direction extending from an inboard direction to an outboard direction, the lower surface being in contact with the upper surface of said first element, the second angle being in a direction which is opposite to the direction of said first angle. The first element and the upper element define a cavity for holding a payload.

Abstract: A method and apparatus for reducing a vibratory response in a structure using a tuning object. A selected mass may be identified for the tuning object. A plurality of channels may be formed in a workpiece having a mass greater than the selected mass to form the tuning object having the selected mass. The tuning object may be bonded to the structure using an adhesive bond to reduce the vibratory response of the structure.

Abstract: An apparatus for harvesting electrical power from mechanical energy is described. The apparatus includes: a flux path. The flux path includes: a magnetic material having a magnetic property that is a function of stress on the magnetic material; a first magnetically conductive material proximate the magnetic material; a magnet in the flux path, wherein a magnetomotive force of the magnet causes magnetic flux; and a component configured to transfer changes in load caused by an external source to the magnetic material.

Abstract: An energy harvester generates electrical energy from mechanical energy using changing flux properties in primary and secondary flux paths. An apparatus includes at least two primary flux paths. The primary flux paths include at least one bias flux path configured to exhibit a change in a flux property in response to a change in an external load applied to the bias flux path. The secondary flux path is magnetically coupled to the primary flux paths. The secondary flux path is configured to experience alternating flux directions in response to the change in the flux property of the bias flux path. Electrical energy can be induced in a conductor as a result of the alternating flux direction in the secondary flux path.

Abstract: Systems include buoys, tethers, and power take-off (PTO) modules to generate electrical energy from the mechanical energy of ocean waves.

Abstract: An apparatus harvests electrical power from mechanical energy. The apparatus includes first and second load-bearing structures, a plurality of magnetostrictive elements, and an electrical circuit or coil. The load-bearing structures experience a force from an external source. The magnetostrictive elements are arranged between the load-bearing structures. The load-bearing structures transfer at least a portion of the force to at least one of the magnetostrictive elements. In this way, at least one of the magnetostrictive elements experiences the force transferred from the load-bearing structures. The force on the magnetostrictive element causes a change in magnetic flux of the magnetostrictive element. The electrical circuit or coil is disposed within a vicinity of the magnetostrictive element which experiences the force. The electrical circuit or coil generates electric power in response to the change in the magnetic flux of the magnetostrictive element.

Abstract: A device generates electrical energy from mechanical motion in a downhole environment. The device converts rotary motion into a linear strain in a magnetostrictive material. The device includes a rotor, a magnetostrictive element, and an electrically conductive coil. The rotor rotates within a stator of a drill string. The magnetostrictive element is attached to the rotor by a first ball joint. The magnetostrictive element is configured to experience axial strain in response to rotational movement of the rotor. The magnetostrictive element includes a second ball joint on an end of the magnetostrictive element opposite the first ball joint. The electrically conductive coil is disposed in proximity to the magnetostrictive element. The electrically conductive coil is configured to generate an electrical current in response to a change in flux density of the magnetostrictive element.

Abstract: Embodiments of an apparatus for harvesting electrical power from fluid motion are described. The apparatus includes a magnetostrictive component having an internal pre-stressed magnetostrictive core. A magnetic property of the magnetostrictive core is configured to change with changes in stress within the magnetostrictive core along at least one direction within the magnetostrictive component. Also, forces at least partially due to fluid motion results in changes of stress within the magnetostrictive core and consequently change the magnetic property. The magnetostrictive component is further configured such that the change in the magnetic property will result in a change in the magnetic flux, which can be used to generate electrical power.

Abstract: An enclosure for carrying an adjustable payload. The enclosure is beneficially used on a rotorcraft blade or other similar structure. The enclosure has a first element having a first flange and an upper element. The first element has an upper surface which has a first angle with respect to a lower surface of the first flange in a direction extending from an inboard direction to an outboard direction. The upper element has a lower surface which has a second angle with respect to an upper surface of said upper element in a direction extending from an inboard direction to an outboard direction, the lower surface being in contact with the upper surface of said first element, the second angle being in a direction which is opposite to the direction of said first angle. The first element and the upper element define a cavity for holding a payload.

Abstract: An apparatus for harvesting electrical power from mechanical energy is described. The apparatus includes at least one magnetostrictive element, at least one electrically conductive coil or circuit, and a magnetic circuit coupled to the electrically conductive coil or circuit to increase or maximize power production. The magnetostrictive element is configured to experience a forced stress and strain in response to external mechanical excitations. The electrically conductive coil or circuit is configured to produce electrical energy through electromagnetic induction.

Abstract: An apparatus for harvesting electrical power from mechanical energy is described. The apparatus includes: a flux path. The flux path includes: a magnetic material having a magnetic property that is a function of stress on the magnetic material; a first magnetically conductive material proximate the magnetic material; a magnet in the flux path, wherein a magnetomotive force of the magnet causes magnetic flux; and a component configured to transfer changes in load caused by an external source to the magnetic material.

Abstract: An apparatus for harvesting electrical power from hydrodynamic energy, the apparatus including a buoy or other water flotation device connected to an anchor by a tether and a magnetostrictive component having an internal pre-stressed magnetostrictive core that experiences at least a part of load changes experienced by the tether. The magnetic property of the magnetostrictive core is configured to change with changes in stress within the magnetostrictive core along at least one direction within the magnetostrictive component. The hydrodynamic energy acting on the buoy or other water flotation device results in changes in force within the tether, which in turn changes the stress within the magnetostrictive core and consequently changes a magnetic property. The magnetostrictive component is also configured such that the change in the magnetic property will result in a change in magnetic flux, which change can be used to generate electrical power.