Patents by Inventor Joseph Gladstone

Joseph Gladstone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10201718
    Abstract: A system for providing monitored radiation therapy has a high energy radiation source, apparatus for excluding uncontrolled ambient light, and apparatus for collecting light emitted from a subject. The system has apparatus for spectrally analyzing the collected light, and a processor for determining oxygenation or other metabolic function of tissue within the subject from spectral analysis of the collected light. The system monitors radiation therapy by providing a beam of high energy radiation; collecting Cherenkov and/or photoluminescent light from the subject, the light generated along the beam; spectrally analyzing the light; and determining oxygenation or metabolic function of tissue from the spectral analysis. Beam profile of the system is calibrated by imaging from multiple angles Cherenkov and/or photoluminescent light emitted by a phantom placed in the beam in lieu of a subject, captured images are analyzed to determine beam profile.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: February 12, 2019
    Assignee: THE TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Brian William Pogue, David Joseph Gladstone, Scott Christian Davis, Johan Jakob Axelsoon, Adam Kenneth Glaser, Rongxiao Zhang
  • Publication number: 20140114150
    Abstract: A system for providing monitored radiation therapy has a high energy radiation source, apparatus for excluding uncontrolled ambient light, and apparatus for collecting light emitted from a subject. The system has apparatus for spectrally analyzing the collected light, and a processor for determining oxygenation or other metabolic function of tissue within the subject from spectral analysis of the collected light. The system monitors radiation therapy by providing a beam of high energy radiation; collecting Cherenkov and/or photoluminescent light from the subject, the light generated along the beam; spectrally analyzing the light; and determining oxygenation or metabolic function of tissue from the spectral analysis. Beam profile of the system is calibrated by imaging from multiple angles Cherenkov and/or photoluminescent light emitted by a phantom placed in the beam in lieu of a subject, captured images are analyzed to determine beam profile.
    Type: Application
    Filed: May 18, 2012
    Publication date: April 24, 2014
    Applicant: The Trustees of Dartmouth College
    Inventors: Brian William Pogue, David Joseph Gladstone, Scott Christian Davis, Johan Jakob Axelsoon, Adam Kenneth Glaser, Rongxiao Zhang
  • Patent number: 4193549
    Abstract: An arm/rotor hub assembly comprises a hollow rotor and a plurality of hollow arms, each of the arms passing through a corresponding aperture of the rotor sidewall and having one end thereof extending outwardly of the rotor in a generally transverse direction and the other end thereof disposed within the rotor and flared outwardly to a diameter greater than that of the corresponding aperture. The inner surface of the rotor sidewall defines a recess adjacent each of the apertures, and the rotor other ends have a portion thereof at least partially disposed within the recess adjacent the corresponding aperture. The assembly is put together by inserting the other arm ends through the corresponding apertures and employing a flaring tool inserted into the rotor through the open rotor end to flare the other arm ends outwardly within the rotor to a diameter greater than the apertures and force some portions of the other arm ends into the recesses and other portions intermediate the apertures and the open rotor end.
    Type: Grant
    Filed: July 24, 1978
    Date of Patent: March 18, 1980
    Assignee: Beatrice Foods Co.
    Inventor: Joseph Gladstone