Abstract: Various implementations include systems and approaches for determining user oxygen saturation level, and in certain cases, performing an action based on that determination. Particular aspects include a monitoring system having at least one pressure sensor for detecting air pressure in an environment proximate the at least one pressure sensor, and a processor coupled with the at least one pressure sensor, where the processor is programmed to receive air pressure data from the pressure sensor about the environment, determine an oxygen saturation level for a user in the environment based on the air pressure data, and in response to determining the oxygen saturation level of the user has met one or more predetermined conditions, perform an action.

Abstract: A system for detection of non-pneumatic tire loading includes a non-pneumatic tire. The non-pneumatic tire includes a ground-contacting annular tread, a central rim, and at least one spoke disk disposed between the rim and the tread. The spoke disk includes an inner ring mounted on the central rim, an outer ring, and spokes extending radially between the inner ring and the outer ring. A shear band is disposed between the outer ring of the spoke disk and the tread. A flange is disposed on an outboard surface of the spokes of the spoke disk. Indicating means are formed on the outboard surface of the plurality of spokes of the spoke disk radially outwardly of the flange. The flange interfaces with the indicating means when the tire is in an overloaded state or is in need of replacement.

Abstract: A sensor pod system includes one or more sensor pods with a plurality of sensors configured to collect data from an environment. The sensor pod system may include a cleaning system to clean sensing surfaces of sensor pods during operation. The sensor pod system may include sensors of different types and modalities. Sensor pods of the sensor pod system may be modularly installed on a vehicle, for example, an autonomous vehicle and collect and provide data of the environment during operation of the vehicle.

Abstract: A vehicle includes a first axle having a first electric machine, a second axle having a second electric machine and a controller. The controller is programmed to, in a user-selected four-wheel drive mode, command a first torque to the first electric machine based on a driver-demanded torque and a speed of the second axle, and command a second torque to the second electric machine based on a comparison of the driver-demanded torque and the first torque and further based on a speed of the first axle.

Abstract: A system and method for a face mask communication system. The face mask communication system includes a removable microphone that can be installed in a face mask to allow the wearer to clearly and privately communicate with another user over a Bluetooth enabled mobile device such as a cell phone. In illustrated examples, a microphone unit is deformable to enable the microphone unit to form a custom fit over the nose bridge to seal the mask on the user's face. The face mask communication system includes an application program operating on the mobile device that allows a user to initiate and secure private conversations with other users.

Abstract: First information associating a first unique master identifier with multiple different aliases is obtained from a first database accessible to an enrichment-content delivery system. The first unique master identifier is assigned to a first primary content item. Second information, which links the first unique master identifier to first enrichment content is obtained from a second database accessible to the enrichment-content delivery system. First playout information, which includes a first alias identifying a first media item scheduled for playout by a first media station is received from the first media station. A determination is made based on the first information and the second information, that the first alias is associated with the first unique master identifier assigned to the first primary content item. In response to that determination, the first enrichment content is transmitted to the first media station.

Abstract: In one aspect, a method for filtering out erroneous sequence reads from a genomic sequence dataset, is disclosed. The genomic sequence dataset is received by one or more processors. The dataset is comprised of a plurality of fragment sequence reads, each with an associated barcode sequence and a unique identifier sequence. A threshold value for filtering out select fragment sequence reads from the genomic sequence dataset is determined by the one or more processors. The threshold value is a number of fragment sequence reads in the genomic sequence dataset with the same unique identifier sequence. Fragment sequence reads with the same unique identifier sequence occurring at less than the threshold value in the genomic sequence dataset is filtered out by the one or more processors. A filtered genomic sequence dataset is generated by the one or more processors.

Abstract: Method for identifying a subset of cells from a dataset for targeted gene expression analysis, comprising: defining an expected total recovered cell count for a barcode dataset; determining a region of interest for the total recovered cell count by calculating a lower bound for the region; and (b) calculating an upper bound for the region of interest by including an additional subset of barcodes having molecule counts below the lower bound; fitting the barcode dataset to a model; wherein the model groups barcodes as a function of molecule count; identifying a cut-off value on the model, wherein all barcodes having a molecule count above the cut-off value are called as cells; and identifying a targeted subset of cells from the called cells for conducting targeted gene expression, wherein a cell qualifies as part of the targeted subset if the cell has a molecule count above a target threshold.

Abstract: The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

Abstract: A system and method for a face mask communication system. The face mask communication system includes a removable microphone that can be installed in a face mask to allow the wearer to clearly and privately communicate with another user over a Bluetooth enabled mobile device such as a cell phone. In illustrated examples, a microphone unit is deformable to enable the microphone unit to form a custom fit over the nose bridge to seal the mask on the user's face. The face mask communication system includes an application program operating on the mobile device that allows a user to initiate and secure private conversations with other users.

Abstract: The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

Abstract: A data processing system for end-to-end configuration assistance for cloud services implements receiving a request from a client device for a solution assistant configured to provide step-by-step guidance for configuring a plurality of cloud services to interoperate to produce a specified result; causing to be presented a solution assistant user interface; providing the step-by-step guidance comprising a plurality of steps by: launching a configuration interface of a respective cloud service of the plurality of cloud services associated with a respective step of the plurality of steps; presenting step-by-step configuration information providing guidance for configuring the respective cloud service; and receiving a confirmation indication from the client device that the respective cloud service has been configured according to the step-by-step configuration information; generating a summary report that includes a summary of the cloud services configured using the solution assistant; and causing to be presented

Abstract: The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

Abstract: The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

Abstract: This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.

Abstract: This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.

Abstract: The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

Abstract: This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.

Abstract: The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

Abstract: The present invention provides cyclobutyl substituted pyrrolopyrimidines and pyrrolopyridines of Formula I: wherein X, Y, Z, L, A, R5, n and m are defined above, as well as their compositions and methods of use, that modulate the activity of Janus kinases (JAKs) and are useful in the treatment of diseases related to the activity of JAKs including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.