Patents by Inventor Joseph Guiles

Joseph Guiles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibacteriall heterocyclic ureas
    Patent number: 8716320
    Abstract: The present invention provides novel heterocyclic urea compounds having useful antibacterial activity, pharmaceutical compositions comprising one or more of these compounds, methods of making the same, and methods of using the same.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: May 6, 2014
    Assignee: Replidyne, Inc.
    Inventors: Joseph Guiles, Thale Jarvis, Sarah Strong, Xicheng Sun
  • Substituted phenylether-thienopyridone compounds with antibacterial activity
    Patent number: 8697720
    Abstract: Novel bicyclic heteroaromatic compounds are provided that are inhibitors of bacterial methionyl tRNA synthetase (MetRS). Compounds of the invention generally have a left hand side phenylether constituent and a right hand side thienopyridone constituent. Also disclosed are methods for their preparation and their use in therapy as antibacterial agents, particularly as anti-Clostridium difficile agents.
    Type: Grant
    Filed: September 11, 2007
    Date of Patent: April 15, 2014
    Assignee: Crestone, Inc.
    Inventors: Joseph Guiles, Xicheng Sun, Nebojsa Janjic, Sarah Strong
  • Methods and compounds for treatment of clostridium based infection
    Patent number: 8658670
    Abstract: Methionyl tRNA synthetase inhibitors (MetRS) are provided for use in therapy as antibacterial agents in Clostridium based infection.
    Type: Grant
    Filed: September 11, 2007
    Date of Patent: February 25, 2014
    Assignee: Crestone, Inc.
    Inventors: Joseph Guiles, Xicheng Sun, Nebojsa Janjic, Sarah Strong
  • TRIAZOLIUM CARBENE CATALYSTS AND PROCESSES FOR ASYMMETRIC CARBON-CARBON BOND FORMATION
    Publication number: 20130116445
    Abstract: Provided herein are chiral triazolium catalysts useful for asymmetric C—C bond formation and processes for their preparation. Also provided are synthetic reactions in which these catalysts are used, in particular, in asymmetric C—C bond formation.
    Type: Application
    Filed: July 12, 2011
    Publication date: May 9, 2013
    Applicant: Colorado State University Research Foundation
    Inventors: Tomislav Rovis, Daniel Dirocco, Joseph Guiles
  • Antibacterial sulfone and sulfoxide substituted heterocyclic urea compounds
    Patent number: 8293919
    Abstract: The present invention provides novel sulfone and sulfoxide substituted heterocyclic urea compounds having useful antibacterial activity. Use of these compounds as pharmaceutical compositions and methods of production are provided.
    Type: Grant
    Filed: July 23, 2008
    Date of Patent: October 23, 2012
    Assignee: Crestone, Inc.
    Inventors: Joseph Guiles, Thale Jarvis, Sarah Strong, Xicheng Sun, Jian Qiu, John C. Rohloff
  • Antibacterial amide and sulfonamide substituted heterocyclic urea compounds
    Patent number: 8148380
    Abstract: The present invention provides novel amide and sulfonamide substituted heterocyclic urea compounds having useful antibacterial activity. Use of these compounds as pharmaceutical compositions and method of their production are also provided.
    Type: Grant
    Filed: July 23, 2008
    Date of Patent: April 3, 2012
    Assignee: Crestone, Inc.
    Inventors: Joseph Guiles, Thale Jarvis, Sarah Strong, Xicheng Sun, Jian Qiu, John C. Rohloff
  • Antibacterial Amide and Sulfonamide Substituted Heterocyclic Urea Compounds
    Publication number: 20120015941
    Abstract: The present invention provides novel amide and sulfonamide substituted heterocyclic urea compounds having useful antibacterial activity. Use of these compounds as pharmaceutical compositions and method of their production are also provided.
    Type: Application
    Filed: July 23, 2008
    Publication date: January 19, 2012
    Applicant: CRESTONE, INC.
    Inventors: Joseph Guiles, Thale Jarvis, Sarah Strong, Xicheng Sun, Jian Qiu, John C. Rohloff
  • Substituted thienopyridone compounds with antibacterial activity
    Patent number: 7994192
    Abstract: Novel bicyclic heteroaromatic compounds are provided that are inhibitors of bacterial methionyl tRNA synthetase (MetRS). Compounds of the invention generally have a left hand side chroman group or left hand side tetrahydroquinoline group and a right hand side thienopyridone group. Also disclosed are methods for their preparation and their use in therapy as antibacterial agents, particularly as anti-Clostridium difficile agents.
    Type: Grant
    Filed: September 11, 2007
    Date of Patent: August 9, 2011
    Assignee: Crestone, Inc.
    Inventors: Joseph Guiles, Xicheng Sun, Nebojsa Janjic, Sarah Strong
  • Enantiomeric compounds with antibacterial activity
    Patent number: 7973050
    Abstract: Novel compounds in enantiomeric excess that are inhibitors of bacterial methionyl synthetase (MetRS) are disclosed. Also disclosed are methods for their preparation and their use in therapy as antibacterial agents, and in particular their use in therapy for Clostridium difficile infection.
    Type: Grant
    Filed: September 11, 2007
    Date of Patent: July 5, 2011
    Assignee: Crestone, Inc.
    Inventors: Joseph Guiles, Xicheng Sun, Nebojsa Janjic, Sarah Strong, Albert Charles Gyorkos
  • Antibacterial Sulfone and Sulfoxide Substituted Heterocyclic Urea Compounds
    Publication number: 20100286169
    Abstract: The present invention provides novel sulfone and sulfoxide substituted heterocyclic urea compounds having useful antibacterial activity. Use of these compounds as pharmaceutical compositions and methods of production are provided.
    Type: Application
    Filed: July 23, 2008
    Publication date: November 11, 2010
    Applicant: CRESTONE, INC.
    Inventors: Joseph Guiles, Thale Jarvis, Sarah Strong, Xicheng Sun, Jian Qiu, John C. Rohloff
  • METHODS AND COMPOUNDS FOR TREATMENT OF CLOSTRIDIUM BASED INFECTION
    Publication number: 20090163536
    Abstract: Methionyl tRNA synthetase inhibitors (MetRS) are provided for use in therapy as antibacterial agents in Clostridium based infection.
    Type: Application
    Filed: September 11, 2007
    Publication date: June 25, 2009
    Applicant: REPLIDYNE, INC.
    Inventors: JOSEPH GUILES, XICHENG SUN, NEBOJSA JANJIC, SARAH STRONG
  • Substituted Phenylether-Thienopyridone Compounds With Antibacterial Activity
    Publication number: 20080227808
    Abstract: Novel bicyclic heteroaromatic compounds are provided that are inhibitors of bacterial methionyl tRNA synthetase (MetRS). Compounds of the invention generally have a left hand side phenylether constituent and a right hand side thienopyridone constituent. Also disclosed are methods for their preparation and their use in therapy as antibacterial agents, particularly as anti-Clostridium difficile agents.
    Type: Application
    Filed: September 11, 2007
    Publication date: September 18, 2008
    Applicant: REPLIDYNE, INC.
    Inventors: JOSEPH GUILES, XICHENG SUN, NEBOJSA JANJIC, SARAH STRONG
  • Antibacterial heterocyclic ureas
    Publication number: 20080207703
    Abstract: The present invention provides novel heterocyclic urea compounds having useful antibacterial activity, pharmaceutical compositions comprising one or more of these compounds, methods of making the same, and methods of using the same.
    Type: Application
    Filed: July 23, 2007
    Publication date: August 28, 2008
    Applicant: Replidyne, Inc.
    Inventors: Joseph Guiles, Thale Jarvis, Sarah Strong, Xicheng Sun
  • Substituted Thienopyridone Compounds With Antibacterial Activity
    Publication number: 20080146609
    Abstract: Novel bicyclic heteroaromatic compounds are provided that are inhibitors of bacterial methionyl tRNA synthetase (MetRS). Compounds of the invention generally have a left hand side chroman group or left hand side tetrahydroquinoline group and a right hand side thienopyridone group. Also disclosed are methods for their preparation and their use in therapy as antibacterial agents, particularly as anti-Clostridium difficile agents.
    Type: Application
    Filed: September 11, 2007
    Publication date: June 19, 2008
    Applicant: REPLIDYNE, INC.
    Inventors: Joseph GUILES, Xicheng SUN, Nebojsa JANJIC, Sarah STRONG
  • Enantiomeric Compounds With Antibacterial Activity
    Publication number: 20080108651
    Abstract: Novel compounds in enantiomeric excess that are inhibitors of bacterial methionyl synthetase (MetRS) are disclosed. Also disclosed are methods for their preparation and their use in therapy as antibacterial agents, and in particular their use in therapy for Clostridium difficile infection.
    Type: Application
    Filed: September 11, 2007
    Publication date: May 8, 2008
    Applicant: REPLIDYNE, INC.
    Inventors: Joseph GUILES, Xicheng SUN, Nebojsa JANJIC, Sarah STRONG, Albert GYORKOS
  • Substituted thiophenes with antibacterial activity
    Publication number: 20060128735
    Abstract: Novel substituted thiophenes that are inhibitors of bacterial methionyl t-RNA synthetase (MRS) are disclosed. Also disclosed are method for their preparation and their use in therapy as anti-bacterial agents.
    Type: Application
    Filed: January 30, 2006
    Publication date: June 15, 2006
    Applicant: REPLIDYNE, INC.
    Inventors: John Berge, Richard Jarvest, Catherine Frydrych, Joseph Guiles, Jian Qiu, Theodore Tarasow
  • Substituted thiophenes with antibacterial activity
    Patent number: 7030137
    Abstract: Novel substituted thiophenes that are inhibitors of bacterial methionyl t-RNA synthetase (MRS) are disclosed. Also disclosed are method for their preparation and their use in therapy as anti-bacterial agents.
    Type: Grant
    Filed: February 27, 2004
    Date of Patent: April 18, 2006
    Assignee: Replidyne, Inc.
    Inventors: John Berge, Richard Jarvest, Catherine Simone Victoire Frydrych, Joseph Guiles, Jian Qiu, Theodore M. Tarasow
  • Bis-quinazoline compounds for the treatment of bacterial infections
    Publication number: 20050124562
    Abstract: Bis-quinazoline compounds based on the compound (3,4-Dihydro-quinazolin-2-yl)-quinazolin-2-yl-amine, and methods of use of the compounds as inhibitors of bacterial DNA polymerase holoenzymes and in the treatment of bacterial infections are described.
    Type: Application
    Filed: September 23, 2004
    Publication date: June 9, 2005
    Inventors: Joseph Guiles, Garry Dallmann, Nebojsa Janjic, Charles McHenry, Xicheng Sun, Ming Tregay
  • Substituted thiophenes with antibacterial activity
    Publication number: 20050009833
    Abstract: Novel substituted thiophenes that are inhibitors of bacterial methionyl t-RNA synthetase (MRS) are disclosed. Also disclosed are method for their preparation and their use in therapy as anti-bacterial agents.
    Type: Application
    Filed: February 27, 2004
    Publication date: January 13, 2005
    Inventors: John Berge, Richard Jarvest, Catherine Frydrych, Joseph Guiles, Jian Qiu, Theodore Tarasow
  • Antibacterial methods and compositions
    Publication number: 20040224981
    Abstract: Disclosed is a pharmaceutical composition comprising an aminoacyl tRNA synthetase inhibitor and another antibacterial agent, including another aminoacyl tRNA synthetase inhibitor.
    Type: Application
    Filed: May 3, 2004
    Publication date: November 11, 2004
    Inventors: Nebojsa Janjic, Ian A. Critchley, Joseph Guiles, Theodore M. Tarasow