Patents by Inventor Joseph H. Golias
Joseph H. Golias has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5595664Abstract: An analyzer system for automatic column chromatography includes chromatographic columns which are mounted in a rack. A drop removal mechanism system shakes the rack to transfer the last drop of eluate from the tip of a chromatographic column to a receptacle below the tip before the column is repositioned over another receptacle and another fluid or operation is introduced into the column. This prevents one eluate from contaminating another. The chromatographic column may have an upper end which is sealed by a foil member. During use, the foil member is ruptured by lowering a pressure cylinder with a seal-punching head against it. The pressure cylinder, which is part of the pressure tip unit, is then withdrawn so that fluid can be introduced into the column via the ruptured foil member. The pressure tip unit is then lowered into sealing engagement with the column so that pressure can be applied via a bore in the pressure cylinder.Type: GrantFiled: June 6, 1995Date of Patent: January 21, 1997Assignee: Helena Laboratories CorporationInventors: James R. M. Sanford, Patrick M. Frank, Joseph H. Golias, William C. Jennings
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Patent number: 5589063Abstract: An analyzer system for automatic column chromatography includes chromatographic columns which are mounted in a rack. A drop removal mechanism system shakes the rack to transfer the last drop of eluate from the tip of a chromatographic column to a receptacle below the tip before the column is repositioned over another receptacle and another fluid or operation is introduced into the column. This prevents one eluate from contaminating another. The chromatographic column may have an upper end which is sealed by a foil member. During use, the foil member is ruptured by lowering a pressure cylinder with a seal-punching head against it. The pressure cylinder, which is part of the pressure tip unit, is then withdrawn so that fluid can be introduced into the column via the ruptured foil member. The pressure tip unit is then lowered into sealing engagement with the column so that pressure can be applied via a bore in the pressure cylinder.Type: GrantFiled: June 6, 1995Date of Patent: December 31, 1996Assignee: Helena Laboratories CorporationInventors: James R. M. Sanford, Patrick M. Frank, Joseph H. Golias, William C. Jennings
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Patent number: 5441645Abstract: An analyzer system for automatic column chromatography includes chromatographic columns which are mounted in a rack. A drop removal mechanism system shakes the rack to transfer the last drop of eluate from the tip of a chromatographic column to a receptacle below the tip before the column is repositioned over another receptacle and another fluid or operation is introduced into the column. This prevents one eluate from contaminating another. The chromatographic column may have an upper end which is sealed by a foil member. During use, the foil member is ruptured by lowering a pressure cylinder with a seal-punching head against it. The pressure cylinder, which is part of the pressure tip unit, is then withdrawn so that fluid can be introduced into the column via the ruptured foil member. The pressure tip unit is then lowered into sealing engagement with the column so that pressure can be applied via a bore in the pressure cylinder.Type: GrantFiled: September 16, 1994Date of Patent: August 15, 1995Assignee: Helena Laboratories CorporationInventors: James R. M. Sanford, Patrick M. Frank, Joseph H. Golias, William C. Jennings
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Patent number: 5400923Abstract: A pump for discharging the contents of a sealed container, such as a test tube, is connected to a body member which includes an inlet path and a discharge path with a delivery tube in the discharge path. A predetermined clearance is provided between the exterior of the delivery tube and the interior of the discharge path, the clearance providing venting, or blow-by, such that temperature changes do not cause accidental discharge of the contents of the container, while still maintaining sufficient resistance to venting for permitting pressurizing the interior of the test tube with the pump for accurately controlling the discharge of the test tube contents. A second or supplemental vent is provided in the pump.Type: GrantFiled: April 4, 1990Date of Patent: March 28, 1995Assignee: Helena Laboratories CorporationInventors: Tipton L. Golias, Robert J. Sarrine, Joseph H. Golias, Ronald A. Mayes
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Patent number: 5358641Abstract: An analyzer system for automatic column chromatography includes chromatographic columns which are mounted in a rack. A drop removal mechanism system shakes the rack to transfer the last drop of eluate from the tip of a chromatographic column to a receptacle below the tip before the column is repositioned over another receptacle and another fluid or operation is introduced into the column. This prevents one eluate from contaminating another. The chromatographic column may have an upper end which is sealed by a foil member. During use, the foil member is ruptured by lowering a pressure cylinder with a seal-punching head against it. The pressure cylinder, which is part of the pressure tip unit, is then withdrawn so that fluid can be introduced into the column via the ruptured foil member. The pressure tip unit is then lowered into sealing engagement with the column so that pressure can be applied via a bore in the pressure cylinder.Type: GrantFiled: May 10, 1993Date of Patent: October 25, 1994Assignee: Helena Laboratories CorporationInventors: James R. M. Sanford, Patrick M. Frank, Joseph H. Golias, William C. Jennings
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Patent number: 5228988Abstract: An analyzer system for automatic column chromatography includes chromatographic columns which are mounted in a rack. A drop removal mechanism system shakes the rack to transfer the last drop of eluate from the tip of a chromatographic column to a receptacle below the tip before the column is repositioned over another receptacle and another fluid or operation is introduced into the column. This prevents one eluate from contaminating another. The chromatographic column may have an upper end which is sealed by a foil member. During use, the foil member is ruptured by lowering a pressure cylinder with a seal-punching head against it. The pressure cylinder, which is part of the pressure tip unit, is then withdrawn so that fluid can be introduced into the column via the ruptured foil member. The pressure tip unit is then lowered into sealing engagement with the column so that pressure can be applied via a bore in the pressure cylinder.Type: GrantFiled: October 22, 1991Date of Patent: July 20, 1993Assignee: Helena Laboratories CorporationInventors: James R. M. Sanford, Patrick M. Frank, Joseph H. Golias, William C. Jennings
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Patent number: 5114033Abstract: An apparatus for discharging the contents of a sealed container, such as a test tube, includes an inlet path and a discharge path with a delivery tube in the discharge path. A predetermined clearance is provided between the exterior of the delivery tube and the interior of the discharge path, the clearance providing venting, or blow-by, such that temperature changes do not cause accidental discharge of the contents of the container, while still maintaining sufficient resistance to venting for permitting pressurizing the interior of the test tube for accurately controlling the discharge of the test tube contents.Type: GrantFiled: July 21, 1989Date of Patent: May 19, 1992Assignee: Helena Laboratories CorporationInventors: Tipton L. Golias, Robert J. Sarrine, Joseph H. Golias
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Patent number: 5045208Abstract: An analyzer system for automatic column chromatography, and method for its use, includes an array of chromatograph columns and multi-cell cuvettes associated with each column. Chromatographic separation takes place under a constant, low fluid pressure. A pressure system distributes air to each column during chromatographic separation but prevents leakage of air if the column array is partially empty. The multi-cell cuvette collects and separates the eluates associated with a single column. The system provides for automatic removal of caps from the bottoms of the chromatograph columns and provides for automatic optical density reading.Type: GrantFiled: October 27, 1989Date of Patent: September 3, 1991Assignee: Helena Laboratories CorporationInventors: James R. M. Sanford, Patrick M. Frank, Joseph H. Golias, William C. Jennings