Patents by Inventor Joseph Hacia

Joseph Hacia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gene therapy for treating peroxisomal disorders
    Patent number: 11793887
    Abstract: Methods and compositions are provided for treatment of peroxisomal biogenesis disorders (PBDs). More particularly, recombinant adeno-associated viruses (rAAV) provided in the form of compositions are used to deliver a nucleic acid encoding human PEX1 to host cells. The rAAVs comprise a AAV capsid, and packaged therein a vector genome comprising an AAV 5? inverted terminal repeat (ITR) sequence; a promoter; a coding sequence encoding a human PEX1; and an AAV 3? ITR.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: October 24, 2023
    Assignees: The Trustees of the University of Pennsylvania, University of Southern California, The Research Institute of McGill University Health Centre
    Inventors: Nancy Braverman, Catherine Argyriou, Joseph Hacia, Jean Bennett, Junwei Sun, Ji Yun Song, Devin McDougald
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF ZELLWEGER SPECTRUM DISORDER
    Publication number: 20210315885
    Abstract: Provided herein are methods of treating Zellweger spectrum disorder (ZSD) in a subject in need thereof or improving peroxisome assembly in a cell in need thereof comprising administering to the subject a therapeutically effective amount of Compounds of Formula I or II.
    Type: Application
    Filed: June 18, 2021
    Publication date: October 14, 2021
    Inventors: Joseph Hacia, Nancy E. Braverman, Patricia Dranchak, James Inglese
  • Compositions and methods for the treatment of Zellweger spectrum disorder
    Patent number: 11065247
    Abstract: Provided herein are methods of treating Zellweger spectrum disorder (ZSD) in a subject in need thereof or improving peroxisome assembly in a cell in need thereof comprising administering to the subject a therapeutically effective amount of Compounds of Formula I or II.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: July 20, 2021
    Inventors: Joseph Hacia, Nancy E. Braverman, Patricia Dranchak, James Inglese
  • GENE THERAPY FOR TREATING PEROXISOMAL DISORDERS
    Publication number: 20200093937
    Abstract: Methods and compositions are provided for treatment of peroxisomal biogenesis disorders (PBDs). More particularly, recombinant adeno-associated viruses (rAAV) provided in the form of compositions are used to deliver a nucleic acid encoding human PEX1 to host cells. The rAAVs comprise a AAV capsid, and packaged therein a vector genome comprising an AAV 5? inverted terminal repeat (ITR) sequence; a promoter; a coding sequence encoding a human PEX1; and an AAV 3? ITR.
    Type: Application
    Filed: May 31, 2018
    Publication date: March 26, 2020
    Inventors: Nancy Braverman, Catherine Argyriou, Joseph Hacia, Jean Bennett, Junwei Sun, Ji Yun Song, Devin McDougald
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF ZELLWEGER SPECTRUM DISORDER
    Publication number: 20200046693
    Abstract: Provided herein are methods of treating Zellweger spectrum disorder (ZSD) in a subject in need thereof or improving peroxisome assembly in a cell in need thereof comprising administering to the subject a therapeutically effective amount of Compounds of Formula I or II.
    Type: Application
    Filed: May 20, 2019
    Publication date: February 13, 2020
    Inventors: Joseph Hacia, Nancy E. Braverman, Patricia Dranchak, James Inglese
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF ZELLWEGER SPECTRUM DISORDER
    Publication number: 20180000814
    Abstract: Provided herein are methods of treating Zellweger spectrum disorder (ZSD) in a subject in need thereof or improving peroxisome assembly in a cell in need thereof comprising administering to the subject a therapeutically effective amount of Compounds of Formula I or II.
    Type: Application
    Filed: June 14, 2017
    Publication date: January 4, 2018
    Inventors: Joseph Hacia, Nancy E. Braverman, Patricia Dranchak, James Inglese