Abstract: The invention provides a compact and self-sustained refrigeration system for medical uses, including in hospitals, in clinics and in home uses, including rescue and field emergency situations, independent of external power supply, based on small amounts of liquid carbon dioxide.

Abstract: The invention provides a compact and self-sustained refrigeration system for medical uses, including in hospitals, in clinics and in home uses, including rescue and field emergency situations, independent of external power supply, based on small amounts of liquid carbon dioxide.

Abstract: The present invention provides a system for administering a therapeutic substance to a brain, for example a brain of a person afflicted by a neurodegenerative disorder. The system may include communicating with the person and locating it via a smartphone, characterizing the level of its alertness or cognitive abilities, and initiating the substance release via a vocal signal. The system enables to bypass the blood brain barrier while also reducing undesired systemic concentration peaks of the substance.

Abstract: A portable body-cooling device, comprises: a mask suitable to be positioned on the face of the patient and to cover its mouth and nose; a connector, suitable to connect said mask to a breathable gas container; and a gas container, containing a breathable gas in compressed state, which, when expanded, undergoes cooling. Also described is a method for reducing the body temperature of the patient in need thereof.

Abstract: The present invention provides a method for delivering a substance to the nasal cavity of a subject in which drawing air from a mouthpiece triggers release of a substance to a subject's nasal cavities. The device comprises a container for containing the substance in fluid communication with a nosepiece, a valve with an active configuration and an inactive configuration, and a trigger mechanism to reconfigure the valve from its inactive configuration to its active configuration and vice versa. Drawing air from the mouthpiece, e.g., when the subject takes in air by mouth, activates the trigger mechanism, thereby reconfiguring the valve from its inactive configuration to its active configuration for a predetermined period of time and delivering the substance from the device to a nasal cavity of the subject.

Abstract: Example techniques and systems include detecting patient inhalation with a pulmonary medication dosing device and controlling a valve to release medication based on the detection. For example, a method includes generating a signal indicative of air flow within a portion of a pulmonary medication dosing device, receiving, by a processor, a command based on the signal and associated with a valve configured to at least partially control release of medication via the pulmonary medication dosing device, and controlling, by the processor and based on the received command, the valve to release at least a portion of a dose of the medication into the air flow. In some examples, a mobile computing device may be configured to generate and transmit the command to the pulmonary medication dosing device for controlling the valve.

Abstract: The present invention provides a method for delivering a substance to the nasal cavity of a subject in which drawing air from a mouthpiece triggers release of a substance to a subject's nasal cavities. The device comprises a container for containing the substance in fluid communication with a nosepiece, a valve with an active configuration and an inactive configuration, and a trigger mechanism to reconfigure the valve from its inactive configuration to its active configuration and vice versa. Drawing air from the mouthpiece, e.g., when the subject takes in air by mouth, activates the trigger mechanism, thereby reconfiguring the valve from its inactive configuration to its active configuration for a predetermined period of time and delivering the substance from the device to a nasal cavity of the subject.

Abstract: The present invention provides a method for delivering a substance to the nasal cavity of a subject in which drawing air from a mouthpiece triggers release of a substance to a subject's nasal cavities. The device comprises a container for containing the substance in fluid communication with a nosepiece, a valve with an active configuration and an inactive configuration, and a trigger mechanism to reconfigure the valve from its inactive configuration to its active configuration and vice versa. Drawing air from the mouthpiece, e.g., when the subject takes in air by mouth, activates the trigger mechanism, thereby reconfiguring the valve from its inactive configuration to its active configuration for a predetermined period of time and delivering the substance from the device to a nasal cavity of the subject.

Abstract: The present invention provides a system for administering a therapeutic substance to a brain, for example a brain of a person afflicted by a neurodegenerative disorder. The system may include communicating with the person and locating it via a smartphone, characterizing the level of its alertness or cognitive abilities, and initiating the substance release via a vocal signal. The system enables to bypass the blood brain barrier while also reducing undesired systemic concentration peaks of the substance.

Abstract: A portable body-cooling device, comprises: a mask suitable to be positioned on the face of the patient and to cover its mouth and nose; a connector, suitable to connect said mask to a breathable gas container; and a gas container, containing a breathable gas in compressed state, which, when expanded, undergoes cooling. Also described is a method for reducing the body temperature of the patient in need thereof.

Abstract: The present invention provides an air-intake device for delivering a substance to the nasal cavity of a subject which comprises: a container for containing the substance; a nosepiece and a mouthpiece extending from the device, for placement in proximity to the nose and mouth of the subject, respectively; a valve mechanically connectable to the container, with an active configuration and an inactive configuration; and, a trigger mechanism to reconfigure the valve from the active configuration to the inactive configuration, and vice versa. The trigger mechanism is activated by intaking air through the mouthpiece by the subject. Drawing air from the mouthpiece reconfigures the valve from its inactive configuration to its active configuration for a predetermined period of time and delivers the substance from the device to a nasal cavity of the subject.

Abstract: The present invention provides a method for delivering a substance to the nasal cavity of a subject in which drawing air from a mouthpiece triggers release of a substance to a subject's nasal cavities. The device comprises a container for containing the substance in fluid communication with a nosepiece, a valve with an active configuration and an inactive configuration, and a trigger mechanism to reconfigure the valve from its inactive configuration to its active configuration and vice versa. Drawing air from the mouthpiece, e.g., when the subject takes in air by mouth, activates the trigger mechanism, thereby reconfiguring the valve from its inactive configuration to its active configuration for a predetermined period of time and delivering the substance from the device to a nasal cavity of the subject.

Abstract: A drinking actuated device for delivering a substance to the nasal cavity of a subject, comprising: a container for containing the substance; a nosepiece extending from the device for placement in proximity to the nose of a subject, with the nosepiece in fluid communication with the container; a valve mechanically connectable to the container, characterized by an active configuration and an inactive configuration; and a trigger mechanism adapted to reversibly reconfigure the valve from the active configuration to the inactive configuration. The mouthpiece is fluidly connectable to by means of a tubule to a fluid reservoir containing a fluid. Drawing liquid from the reservoir into the mouth via the mouthpiece reconfigures the valve from the inactive configuration to the active configuration for a predetermined period of time in response to the pressure gradient generated by the suction applied by the subject to the tubule.

Abstract: Example techniques and systems include detecting patient inhalation with a pulmonary medication dosing device and controlling a valve to release medication based on the detection. For example, a method includes generating a signal indicative of air flow within a portion of a pulmonary medication dosing device, receiving, by a processor, a command based on the signal and associated with a valve configured to at least partially control release of medication via the pulmonary medication dosing device, and controlling, by the processor and based on the received command, the valve to release at least a portion of a dose of the medication into the air flow. In some examples, a mobile computing device may be configured to generate and transmit the command to the pulmonary medication dosing device for controlling the valve.

Abstract: It is one object of the present invention to provide an air-intake actuated device adapted for delivering a substance to a nasal cavity of a subject, comprising: a. a container for containing said substance; b. a nosepiece extending from said device for placement in proximity to a nose of said subject. c. a valve mechanically connectable to said container, characterized by an ACTIVE CONFIGURATION and an INACTIVE CONFIGURATION; and, d. a trigger mechanism adapted to reconfigure said valve from said ACTIVE CONFIGURATION to said INACTIVE CONFIGURATION, and vice versa; wherein said trigger mechanism is activated by means of said subject intaking air through said mouthpiece; further wherein said trigger mechanism is adapted to reconfigure said valve from said INACTIVE CONFIGURATION to said ACTIVE CONFIGURATION for a predetermined period of time in response to said subject intake of air.