Abstract: A method is provided for preparing a tissue implant for implantation. The method includes harvesting a tissue material from a human or an animal donor, treating the tissue material in a nuclease-containing solution, and thereafter treating the tissue material with an alkaline alcohol solution. The nuclease-containing solution includes an antimicrobial. The alkaline alcohol solution comprises sodium hydroxide and ethanol.

Abstract: A method is provided for preparing a biological tissue for implantation. The method includes providing a biological tissue from a human or animal donor, treating the biological tissue with an antiviral treatment formulation, lysing the biological tissue, decellularizing the biological tissue with a decellularization treatment formulation, and decontaminating the biological tissue with an alkaline alcohol solution. The antiviral treatment formulation may include a solution of peracetic acid and an alcohol, wherein the peracetic acid is present in the antiviral treatment formulation at a concentration from about 0.03% to about 1.2% (v/v). The decellularization solution may include a solution of a polar aprotic solvent, such as dimethyl sulfoxide, benzyl alcohol and ethanol.

Abstract: A method is provided for preparing a tissue implant for implantation. The method includes treating a pericardium tissue material, which has been harvested from a donor and rendered essentially acellular, with a chlorine dioxide treatment solution; and thereafter treating the pericardium tissue material with an antioxidant solution, which comprises ascorbic acid or a salt thereof.

Abstract: A method is provided for preparing a tissue implant for implantation. The method includes harvesting a tissue material from a human or an animal donor, treating the tissue material in a nuclease-containing solution, and thereafter treating the tissue material with an alkaline alcohol solution. The nuclease-containing solution includes an antimicrobial. The alkaline alcohol solution comprises sodium hydroxide and ethanol.

Abstract: A method is provided for preparing a tissue implant for implantation. The method includes harvesting a tissue material from a human or an animal donor, treating the tissue material with water or a hypotonic solution to lyse native cells of the tissue material, treating the tissue material in a nuclease-containing solution which includes an antimicrobial, treating the tissue material with an alkaline alcohol solution, treating the tissue material with a chlorine dioxide treatment solution, and sterilizing the tissue material.

Abstract: A method is provided for preparing a tissue implant for implantation. The method includes treating a pericardium tissue material, which has been harvested from a donor and rendered essentially acellular, with a chlorine dioxide treatment solution; and thereafter treating the pericardium tissue material with an antioxidant solution, which comprises ascorbic acid or a salt thereof.

Abstract: A method is provided for preparing a tissue implant for implantation. The method includes harvesting a tissue material from a human or an animal donor, treating the tissue material in a nuclease-containing solution, and thereafter treating the tissue material with an alkaline alcohol solution. The nuclease-containing solution includes an antimicrobial. The alkaline alcohol solution comprises sodium hydroxide and ethanol.

Abstract: An antibiotic composition is provided for use in decontaminating biological tissue, for example, graft tissues for transplantation or preparation for terminal sterilization. The antibiotic composition is a physiological solution includes a lantibiotic, such as nisin. The antibiotic solution is effective to substantially inhibit bacterial growth of at least one type of gram-positive bacteria while substantially maintaining the physiological characteristics of the tissue. The method may include contacting the tissue with the antimicrobial composition at a temperature and for a period of time effective to substantially inhibit bacterial growth of the at least one type of gram-positive bacteria while substantially maintaining the physiological characteristics of the tissue.

Abstract: This invention relates to the sterilization and preservation of tissue for storage. More specifically, the invention relates to a method of using a solution to form a preserved tissue. The solution includes a radical scavenger at a concentration believed to reduce the damage to the tissue that could otherwise occur during sterilization with ionizing radiation.

Abstract: A retaining feature is provided for connecting a plastic tube to a corrugated acoustic duct. The retaining feature accommodates variations in the undulations and thread pattern of the corrugated duct, while at the same time minimizing the materials, specialized equipment or tools, labor and cost of making a successful connection. The retaining feature includes at least one barb extending circumferentially around the exterior surface of the plastic tube. Each barb is sized and structured to engage an undulation of the corrugated duct.

Abstract: A throttle body for use in the air intake system of a motor vehicle comprising a throttle body defining a throttle bore. The throttle plate is rotatably mounted within the throttle bore, having an outside diameter smaller than an inside diameter of the throttle bore. A plurality of fins, located on the throttle plate, extend from the throttle plate in a direction generally perpendicular to a plane defined by said throttle plate. The fins are optimized in number, thickness, spacing, length, shape, and angle to reduce air-rush noise without impacting engine performance.

Abstract: A novel solution for cryopreservation of a tissue that includes water, a bio-compatible buffer, a cell-impermeant constituent, a cell-permeant constituent, and a radical scavenger is disclosed. The solution may be used to preserve the tissue for, later transplantation in an animal, including human, host. The radical scavenger is believed to reduce damage to the tissue that could otherwise occur during sterilization with ionizing radiation.

Abstract: A throttle body for use in the air intake system of a motor vehicle comprising a throttle body defining a throttle bore. The throttle plate is rotatably mounted within the throttle bore, having an outside diameter smaller than an inside diameter of the throttle bore. A plurality of fins, located on the throttle plate, extend from the throttle plate in a direction generally perpendicular to a plane defined by said throttle plate. The fins are optimized in number, thickness, spacing, length, shape, and angle to reduce air-rush noise without impacting engine performance.

Abstract: A throttle body (12), for an air intake system of a vehicle, including a housing (14) formed of a thermoplastic material and including a pair of throttle shaft bearing pockets (24, 26) extending from a main bore (16) of the throttle body. The bearing pockets (24, 26) each include a generally cylindrical wall (34) of a diameter to allow for a press fit of throttle shaft support bearings (28, 30) therein. After insertion, a swaging process secures the bearings (28, 30) into the pockets (24, 26) by forming lips (40) around the bearings. The walls (34) may include axial grooves (36) to allow for a more controlled swaging operation.