Abstract: A breaching system for a primary weapon includes a breaching tool secured at a point below said barrel. The breaching tool may include an exterior sleeve portion that is slidable towards a butt-end of the weapon for firing the breaching tool.

Abstract: Innovations in user interface (“UI”) features of an electronic gaming device, and in features of backend processing to implement the UI features, are presented. For example, control logic selects active reels, which include side reels and main reels. Compared to the main reels, the side reels typically include symbols of greater interest to a user. The control logic also selects a subset of the active reels. The control logic spins at least some of the active reels on a display screen of the device. The control logic shifts some active reels into a reel area while shifting other active reels out of the reel area, before stopping at the subset of the active reels. Reel shifting can increase game volatility while maintaining a designated level of return to player.

Abstract: Methods and compositions for extracting nucleic acids such as microRNAs (miRNAs) from biological samples are provided. Aspects of the methods include contacting a biological sample with proteinase K followed by contact with ferric oxide particles under acidic conditions to induce binding between the ferric oxide particles and nucleic acids (e.g., miRNAs) of the sample. In some cases, the ferric oxide particles are provided as part of a dissolvable film, which releases the ferric oxide particles upon solvation. In some embodiments, after nucleic acids bind to the ferric oxide particles, the particles are magnetically separated from the sample and are contacted with an alkaline elution buffer to release the nucleic acids.

Abstract: Embodiments of the present technology pertain to a system for hyper-localized immobilization of a bone structures. In various embodiments the system includes a power supply, the power supply being internal or external to a patient and allowing for variable control of electric current from the power supply. Embodiments further include a first micro-electromagnet being internal to the patient and being placed in a first bracket that is secured to a first side of the bone structure generating half of an electromagnetic attractive force that will immobilize the other bone structure when a second micro-electromagnet being internal to the patient is placed in a second bracket that is secured to a second side of the bone structure generating the electromagnetic attractive force that immobilizes the bone structure. This method could be applied to stabilize or fixate bone fracture sites when electromagnets leverage attractive forces.

Abstract: The present disclosure describes a signal relay node that is physically displaceable by a delivery system to move the signal relay node to a different location, to enable the signal relay node to overcome physical obstructions to signal propagation. A delivery system, such as a launching system, can launch the signal relay node encased within a housing unit, such as a projectile cap. Upon launch into the air, an additional aloft package may provide an aerostat, parachute, and/or a propeller and motor system to keep the signal relay node aloft in the air for a longer period of time.

Abstract: Embodiments of the present technology pertain to a system for hyper-localized immobilization of a bone structures. In various embodiments the system includes a power supply, the power supply being internal or external to a patient and allowing for variable control of electric current from the power supply. Embodiments further include a first micro-electromagnet being internal to the patient and being placed in a first bracket that is secured to a first side of the bone structure generating half of an electromagnetic attractive force that will immobilize the other bone structure when a second micro-electromagnet being internal to the patient is placed in a second bracket that is secured to a second side of the bone structure generating the electromagnetic attractive force that immobilizes the bone structure. This method could be applied to stabilize or fixate bone fracture sites when electromagnets leverage attractive forces.

Abstract: The method for automatically producing precise tattoo markings on any anatomical body portion automatically by providing a controlled articulated arm carrying a tattoo machine implement. The method also provides a multi-axis positioning platform for supporting and positioning a person, receiving a tattoo, in a prime, optimal, and comfortable position. Also, the method provides choosing, with a selector, a tattoo of choice from any data source of images, as well as applying, rectifying, and mapping, with a physical or virtual design projection and visualization media, the chosen tattoo to the person. The method completes a tattoo using the articulated arm with the tattoo machine implement producing a precise, accurate, and aesthetically pleasing tattoo, automatically.

Abstract: The present disclosure describes a signal relay node that is physically displaceable by a delivery system to move the signal relay node to a different location, to enable the signal relay node to overcome physical obstructions to signal propagation. A delivery system, such as a launching system, can launch the signal relay node encased within a housing unit, such as a projectile cap. Upon launch into the air, an additional aloft package may provide an aerostat, parachute, and/or a propeller and motor system to keep the signal relay node aloft in the air for a longer period of time.

Abstract: The present disclosure describes a signal relay node that is physically displaceable by a delivery system to move the signal relay node to a different location, to enable the signal relay node to overcome physical obstructions to signal propagation. A delivery system, such as a launching system, can launch the signal relay node encased within a housing unit, such as a projectile cap. Upon launch into the air, an additional aloft package may provide an aerostat, parachute, and/or a propeller and motor system to keep the signal relay node aloft in the air for a longer period of time.

Abstract: Methods and compositions for extracting nucleic acids such as microRNAs (miRNAs) from biological samples are provided. Aspects of the methods include contacting a biological sample with proteinase K followed by contact with ferric oxide particles under acidic conditions to induce binding between the ferric oxide particles and nucleic acids (e.g., miRNAs) of the sample. In some cases, the ferric oxide particles are provided as part of a dissolvable film, which releases the ferric oxide particles upon solvation. In some embodiments, after nucleic acids bind to the ferric oxide particles, the particles are magnetically separated from the sample and are contacted with an alkaline elution buffer to release the nucleic acids.

Abstract: Described are system, method, and computer-program product embodiments for performing language-agnostic page stream segmentation. In some embodiments, a method includes receiving a multi-page file associated with a plurality of documents. A plurality of characters present on each page of the set of consecutive pages, including a first page and a second page, of the multi-page file can be detected. A plurality of structural data for each page can be computed based on a position and a font format for one or more of the detected characters. The plurality of structural data between the first page and the second page can be compared to determine whether the second page corresponds to a boundary between two documents of the plurality of documents. The multi-page file can be segmented at the second page in response to determining that the second page corresponds to the boundary.

Abstract: Described are system, method, and computer-program product embodiments for performing language-agnostic page stream segmentation. In some embodiments, a method includes receiving a multi-page file associated with a plurality of documents. A plurality of characters present on each page of the set of consecutive pages, including a first page and a second page, of the multi-page file can be detected. A plurality of structural data for each page can be computed based on a position and a font format for one or more of the detected characters. The plurality of structural data between the first page and the second page can be compared to determine whether the second page corresponds to a boundary between two documents of the plurality of documents. The multi-page file can be segmented at the second page in response to determining that the second page corresponds to the boundary.

Abstract: The present disclosure describes a signal relay node that is physically displaceable by a delivery system to move the signal relay node to a different location, to enable the signal relay node to overcome physical obstructions to signal propagation. A delivery system, such as a launching system, can launch the signal relay node encased within a housing unit, such as a projectile cap. Upon launch into the air, an additional aloft package may provide an aerostat, parachute, and/or a propeller and motor system to keep the signal relay node aloft in the air for a longer period of time.

Abstract: The method for automatically producing precise tattoo markings on any anatomical body portion automatically by providing a controlled articulated arm carrying a tattoo machine implement. The method also provides a multi-axis positioning platform for supporting and positioning a person, receiving a tattoo, in a prime, optimal, and comfortable position. Also, the method provides choosing, with a selector, a tattoo of choice from any data source of images, as well as applying, rectifying, and mapping, with a physical or virtual design projection and visualization media, the chosen tattoo to the person. The method completes a tattoo using the articulated arm with the tattoo machine implement producing a precise, accurate, and aesthetically pleasing tattoo, automatically.

Abstract: The current disclosure provide a novel human calcium sensing receptor named CaR2 and the nucleotide sequence that encodes the receptor. The disclosure further provides antibodies specific for CaR2. Also disclosed are methods of identifying modulators of the receptor and methods of using the identified modulators to treat calcium receptor mediated conditions.

Abstract: The present invention is directed generally to reduction or inactivation of gene function or gene expression in cells in vitro and in multicellular organisms. The invention encompasses methods for mutating cells using a combination of mutagens, particularly wherein at least one mutagen is an insertional mutagen, to achieve homozygous gene mutation or mutation of multiple genes required cumulatively to achieve a phenotype to create knock-outs, knock-downs, and other modifications in the same cell. The invention is also directed to cells (and libraries thereof) and organisms created by the methods of the invention, including those in which at least one of the genes created by insertional mutagenesis is tagged by means of the insertion sequences thereby allowing identification of the mutated gene(s). The invention is also directed to libraries of mutated cells and their uses.

Abstract: The present invention is directed generally to reduction or inactivation of gene function or gene expression in cells in vitro and in multicellular organisms. The invention encompasses methods for mutating cells using a combination of mutagens, particularly wherein at least one mutagen is an insertional mutagen, to achieve homozygous gene mutation or mutation of multiple genes required cumulatively to achieve a phenotype to create knock-outs, knock-downs, and other modifications in the same cell. The invention is also directed to cells (and libraries thereof) and organisms created by the methods of the invention, including those in which at least one of the genes created by insertional mutagenesis is tagged by means of the insertion sequences thereby allowing identification of the mutated gene(s). The invention is also directed to libraries of mutated cells and their uses.

Abstract: The present invention is directed generally to reduction or inactivation of gene function or gene expression in cells in vitro and in multicellular organisms. The invention encompasses methods for mutating cells using a combination of mutagens, particularly wherein at least one mutagen is an insertional mutagen, to achieve homozygous gene mutation or mutation of multiple genes required cumulatively to achieve a phenotype to create knock-outs, knock-downs, and other modifications in the same cell. The invention is also directed to cells (and libraries thereof) and organisms created by the methods of the invention, including those in which at least one of the genes created by insertional mutagenesis is tagged by means of the insertion sequences thereby allowing identification of the mutated gene(s). The invention is also directed to libraries of mutated cells and their uses.

Abstract: The present invention is directed generally to activating gene expression or causing over-expression of a gene by recombination methods in situ. The invention also is directed generally to methods for expressing an endogenous gene in a cell at levels higher than those normally found in the cell. In one embodiment of the invention, expression of an endogenous gene is activated or increased following integration into the cell, by non-homologous or illegitimate recombination, of a regulatory sequence that activates expression of the gene. The invention also provides methods for the identification, activation, isolation, and/or expression of genes undiscoverable by current methods since no target sequence is necessary for integration. Thus, by the present invention, endogenous genes, including those associated with human disease and development, may be activated and isolated without prior knowledge of the sequence, structure, function, or expression profile of the genes.

Abstract: The present invention is in the fields of molecular biology, cell biology, and genetics. The invention is directed generally to mutating genes in cells in vitro and in multi-cellular organisms. The invention encompasses methods for mutating genes in cells using polynucleotides that act as insertional mutagens. Such methods are used to achieve mutation of a single gene to achieve a desired phenotype as well as mutation of multiple genes, required cumulatively to achieve a desired phenotype, in a cell or in a multi-cellular organism. The invention is also directed to methods of identifying one or more mutated genes, made by the methods of the invention, in cells and in multi-cellular organisms, by means of a tagging property provided by the insertional mutagen(s). The insertional mutagen thus allows identification of one or more genes that are mutated by insertion of an insertional mutagen.