Abstract: The present invention provides an isolated mammalian histamine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by histamine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian histamine receptor.

Abstract: The present invention provides an isolated mammalian adenosine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by adenosine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian adenosine receptor.

Abstract: Nucleic acids encoding mammalian, e.g., rodent, IL-1?, IL-1?, purified IL-1? and IL-1? proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.

Abstract: Disclosed are methods, apparatus, and systems, including computer program products, implementing and using techniques for a method for providing a game on demand over a data network, in a gaming machine. The gaming machine sends a request message for a game application over the data network. In a network mode, the gaming machine receives outputted results from an executed game application over a streaming channel of the data network for network-based game play. During the network-based game play, the game application is downloaded over a download channel of the data network. In a local mode, the gaming machine executes the downloaded game application independent of the network-based game play. The gaming machine switches instantaneously from the network mode to the local mode for machine-based game play, including maintaining a status of the network-based game play.

Abstract: The present invention provides an isolated mammalian histamine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by histamine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian histamine receptor.

Abstract: The present invention provides an isolated mammalian adenosine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by adenosine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian adenosine receptor.

Abstract: Novel chemokines and 7 transmembrane receptors from mammals, reagents related thereto, including purified proteins, specific antibodies, and nucleic acids encoding the chemokines and receptors are disclosed. Methods of using the chemokines, receptors, reagents and diagnostic kits are also provided.

Abstract: Novel CC chemokines from human, reagents related thereto including purified proteins, specific antibodies and nucleic acids encoding these chemokines are provided. Also provided are methods of making and using said reagents and diagnostic kits.

Abstract: A disclosed a player tracking unit provides a multimedia interface with a display and an interface to one or more sound projection devices and a multimedia board for processing digitally formatted program files for output on the multimedia interface. The player tracking unit may provide menus of audio and video programs, such as a menu for a musical jukebox or a menu for a video-on-demand service. Using a “TV-like” interface, a user may be able to select a program to output on the multimedia interface and control playback features of the program.

Abstract: A gaming device wherein the success or failure of a current selection directly affects the player's chances for success in a later selection and the player's chances for obtaining the highest bonus award possible.

Abstract: Novel CC chemokines from human, reagents related thereto including purified proteins, specific antibodies and nucleic acids encoding these chemokines are provided. Also provided are methods of making and using said reagents and diagnostic kits.

Abstract: The invention is directed to methods and gaming apparatus for allowing a player to participate in a multi-player wagering game. The outcome of the multi-player wagering game may be displayed to the player, along with an alternate outcome display at an alternate outcome display device. The alternate outcome display device may include a rotatable reel and a cover variably disposed in front of the rotatable reel. The gaming apparatus controller may receive a display request where the alternate outcome display device disposes a cover to visibly obscure the reel if the request is to obscure the reel, and disposes the cover to visibly display the reel if the request is to observe the reel.

Abstract: A gaming device having a translating and rotating mechanical display device operable to indicate at least one component of a player's award. In one embodiment the display device is operated as a bonus game of a base game, for example a slot base game. In one embodiment, the object is rotatable and translatable along the same axis. In one embodiment, the object is balloon shaped.

Abstract: A gaming method includes receiving a wager from a player in terms of one or more credits, displaying an image representative of a game, and determining an outcome associated with the game. The method further includes determining if an event has occurred, calculating a purchase cost for each payout in a plurality of payouts when the event occurs, displaying an image representing the plurality of payouts, the image including the payout cost for each payout in the plurality of payouts, receiving a selection from the player of one of the plurality of payouts, receiving from the player the purchase cost of the one of the plurality of payouts selected by the player, and transmitting a request to provide the one of the plurality of payouts to the player.

Abstract: In a gaming method for facilitating game play via a gaming apparatus, the gaming apparatus comprising a controller and a first display unit, the controller communicatively coupled to the first display unit, a game software application may be executed, and value input data may be received. The first display unit may be caused to display a game image representative of one of the following games: poker, blackjack, slots, keno, or bingo. A secondary software application may be executed, and an icon associated with the secondary software application may be displayed simultaneous with the display of the game image, wherein a foreground of the game image is substantially unobstructed by the icon, and wherein the icon is substantially unobstructed by the foreground of the game image. Information may be conveyed using the secondary software application upon detecting an event, and a value payout associated with an outcome of the game may be determined.

Abstract: A gaming device having a card management system which is operable to manage a plurality of circulating data cards. The gaming device includes a card read-write device for reading data cards, a plurality of vertically-stacked card holders for holding a plurality of data cards and one or more card transporters for moving data cards to and from the card holders. The gaming device is operable with a portable card changeover machine. The present invention increases the convenience and efficiency for playing and managing gaming devices.

Abstract: A disclosed player tracking unit provides a display and a player tracking controller designed or configured to provide a web-browser on the display. The player tracking unit may include one or more input devices that can receive selections associated with the web-browser. Furthermore, the player tracking unit can include a multimedia board for processing digitally formatted program files for output on the display.

Abstract: A gaming apparatus may include a display unit, a value input device and a controller operatively coupled to the display unit and the value input device. The controller may include a processor and a memory operatively coupled to the processor. The controller may be programmed to receive preference data relating to the preferences of a player, to select a game from a plurality of available games based upon the player preferences to provide a game selection comprising the selected game, to cause the display unit to generate a game selection display relating to the game selection, to cause the display unit to generate a game display and to determine a value payout associated with an outcome of the game. The game selection display may relate to a game from the game selection. The controller may also be programmed to select a game characteristic based upon the first player preferences.

Abstract: The present invention provides an isolated mammalian histamine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by histamine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian histamine receptor.

Abstract: A method of assembling a gaming device including providing a cabinet including a first side wall and an opposing second side wall and removably connecting a first side panel including a decorative layer to the first side wall of the cabinet. The method includes removably connecting a second side panel including a decorative layer to the second side wall of the cabinet. The method includes securing the first side panel to the first side wall from inside of the cabinet and securing the second side panel to the second side wall from inside of said cabinet, where the first and second panels can only be unsecured from the first and second side walls, respectively, from inside of the cabinet. The method includes movably connecting a lockable door to the cabinet, where the lockable door is movable to allow access to the inside of said cabinet.