Abstract: The disclosure provides methods, treatments and materials for enhancing the effect of an adenosine A2 receptor agonist in the treatment, mitigation or prophylaxis of a disease or condition characterized by inotropic and/or lusitropic dysfunction, and/or enhancing adenosine A2 receptor function in the treatment, mitigation or prophylaxis of a disease or condition characterized by impaired adenosine A2 receptor function, comprising administration of an effective amount of a PDE1 inhibitor to a patient in need thereof, for example a patient suffering from heart failure.

Abstract: Some systems and methods are directed to a device agnostic architecture configured to control and/or manage the interactions between any front end store systems (e.g., self checkout (SCO) systems) for capturing purchase items and backend systems (e.g., point of sale (POS) subsystems) for completing purchase of the items. The device agnostic architecture can include a translation layer or translation component that mediates communications from and/or between the front end and backend systems. For example, the translation layer maps any commands received from any SCO and/or POS device into execution commands native to receiving systems. For example, back-end processing systems can be configured to control on-line identification of products and/or services for purchase, and manage execution of sales of any goods or services. The translation layer manages communication between SCO devices and the backend systems so each communicates with each other according to their respective formats (e.g.

Abstract: Systems, methods, and machine readable medium are provided for replenishing product in a freight tethering environment. A pick list is generated at a hub store including one or more items that need to be replenished at a spoke store. It is determined whether the pick list can be fulfilled by the hub store. If the pick list cannot be fulfilled by the hub store, then the one or more items on the pick list is aggregated to a replenishment need of the hub store. The aggregated replenishment need of the hub store and the spoke store is communicated to a distribution center. Product is received from the distribution center based on the aggregated replenishment need, and the pick list for the spoke store is fulfilled from the received product.

Abstract: Some systems and methods are directed to a device agnostic architecture configured to control and/or manage the interactions between any front end store systems (e.g., self checkout (SCO) systems) for capturing purchase items and backend systems (e.g., point of sale (POS) subsystems) for completing purchase of the items. The device agnostic architecture can include a translation layer or translation component that mediates communications from and/or between the front end and backend systems. For example, the translation layer maps any commands received from any SCO and/or POS device into execution commands native to receiving systems. For example, back-end processing systems can be configured to control on-line identification of products and/or services for purchase, and manage execution of sales of any goods or services. The translation layer manages communication between SCO devices and the backend systems so each communicates with each other according to their respective formats (e.g.

Abstract: A temperature sensor assembly having a support tube defining an interior, a temperature sensor having a distal end and a proximal end located within the interior, and, a concentric ring surrounding at least a portion of the temperature sensor and the concentric ring is positioned between the temperature sensor and the support tube for holding the temperature sensor in the support tube.

Abstract: The present invention relates to certain PDE2 inhibitory compounds, in free or salt form, pharmaceutical compositions containing such compounds and methods for the treatment of PDE2 mediated disorders.

Abstract: Provided are a system and method for determining a weight of an item for purchase, comprising determining from a digital image of an item generated by a single camera, a volume of the item, the single camera separated from the item at a distance in a horizontal and vertical direction established by a stationary rigid fixture; identifying the item; accessing a database to determine an average weight per volume measurement unit of the identified item; and calculating a weight of the item from the volume and the average weight per volume measurement unit.

Abstract: Systems, methods, and machine readable medium are provided for replenishing product in a freight tethering environment. A pick list is generated at a hub store including one or more items that need to be replenished at a spoke store. It is determined whether the pick list can be fulfilled by the hub store. If the pick list cannot be fulfilled by the hub store, then the one or more items on the pick list is aggregated to a replenishment need of the hub store. The aggregated replenishment need of the hub store and the spoke store is communicated to a distribution center. Product is received from the distribution center based on the aggregated replenishment need, and the pick list for the spoke store is fulfilled from the received product.

Abstract: Provided are a system and method for determining a weight of an item for purchase, comprising determining from a digital image of an item generated by a single camera a volume of the item, the single camera separated from the item at a distance in a horizontal and vertical direction established by a stationary rigid fixture; identifying the item; accessing a database to determine an average weight per volume measurement unit of the identified item; and calculating a weight of the item from the volume and the average weight per volume measurement unit.

Abstract: The present invention relates to certain PDE2 inhibitory compounds, in free or salt form, pharmaceutical compositions containing such compounds and methods for the treatment of PDE2 mediated disorders.

Abstract: The present invention relates to certain PDE2 inhibitory compounds, in free or salt form, pharmaceutical compositions containing such compounds and methods for the treatment of PDE2 mediated disorders.

Abstract: The present invention relates to certain PDE2 inhibitory compounds, in free or salt form, pharmaceutical compositions containing such compounds and methods for the treatment of PDE2 mediated disorders.

Abstract: Systems for controlling concentric tube probes are disclosed. In some examples, the system includes a concentric tube position display interface and a control system. The concentric tube display interface includes a display for displaying visual feedback to a user indicating a position (and possibly orientation) of a tip of a concentric tube probe and a user input device for receiving user input from the user designating a goal position (and possibly orientation) for the tip of the concentric tube probe. The control system is configured for interactive-rate motion planning of the concentric tube probe by creating, in real-time or near real-time, a motion plan to move the tip of the concentric tube probe to the goal position (and possibly orientation) while avoiding contact by the concentric tube probe with one or more obstacles and for configuring the concentric tube probe as specified by the motion plan.

Abstract: The present invention relates to a product comprising a PDE1 inhibitor and a PDE2 inhibitor, in free or salt form, pharmaceutical compositions comprising them and their use as pharmaceuticals for the treatment of cAMP and/or cGMP related disorders.

Abstract: The present invention relates to certain PDE2 inhibitory compounds, in free or salt form, pharmaceutical compositions containing such compounds and methods for the treatment of PDE2 mediated disorders.

Abstract: The present invention relates to certain PDE2 inhibitory compounds, in free or salt form, pharmaceutical compositions containing such compounds and methods for the treatment of PDE2 mediated disorders.

Abstract: Provided are a system and method for determining a weight of an item for purchase, comprising determining from a digital image of an item generated by a single camera a volume of the item, the single camera separated from the item at a distance in a horizontal and vertical direction established by a stationary rigid fixture; identifying the item; accessing a database to determine an average weight per volume measurement unit of the identified item; and calculating a weight of the item from the volume and the average weight per volume measurement unit.

Abstract: The present invention relates to a product comprising a PDE1 inhibitor and a PDE2 inhibitor, in free or salt form, pharmaceutical compositions comprising them and their use as pharmaceuticals for the treatment of cAMP and/or cGMP related disorders.

Abstract: Systems, methods, and machine readable medium are provided for replenishing product in a freight tethering environment. A pick list is generated at a hub store including one or more items that need to be replenished at a spoke store. It is determined whether the pick list can be fulfilled by the hub store. If the pick list cannot be fulfilled by the hub store, then the one or more items on the pick list is aggregated to a replenishment need of the hub store. The aggregated replenishment need of the hub store and the spoke store is communicated to a distribution center. Product is received from the distribution center based on the aggregated replenishment need, and the pick list for the spoke store is fulfilled from the received product.

Abstract: Some systems and methods are directed to a device agnostic architecture configured to control and/or manage the interactions between any front end store systems (e.g., self checkout (SCO) systems) for capturing purchase items and backend systems (e.g., point of sale (POS) subsystems) for completing purchase of the items. The device agnostic architecture can include a translation layer or translation component that mediates communications from and/or between the front end and backend systems. For example, the translation layer maps any commands received from any SCO and/or POS device into execution commands native to receiving systems. For example, back-end processing systems can be configured to control on-line identification of products and/or services for purchase, and manage execution of sales of any goods or services. The translation layer manages communication between SCO devices and the backend systems so each communicates with each other according to their respective formats (e.g.