Abstract: A fabrication method includes receiving information corresponding to a first pattern, receiving information corresponding to a second pattern, controlling an extruder to print a first semi-liquid material in the first pattern, and controlling the extruder to print a second semi-liquid material in the second pattern. The extruder controlling operations may be performed to combine the first semi-liquid material with the second semi-liquid material to form a composite having a third pattern. The third pattern may be, for example, a continuously graded three-dimensional multiple-material composite.

Abstract: Multiple colloids or hydrogels may each have a different chemical composition. A printer may extrude the colloids or hydrogels to form a physical object, in such a way that which hydrogel or colloid is deposited—or the amount of each hydrogel or colloid that is deposited—varies as a function of spatial position. Thus, the material composition and material properties of the physical object may vary at different locations. In some cases, physical properties of the structure being fabricated, such as surface roughness and hydrophilicity, are directly related to relative proportions of the materials being deposited and their fabrication processes. In some cases, cells, microorganisms, nutrients or other bioactive materials are embedded in or introduced to the fabricated structure. In some cases, the different materials in different spatial positions in the fabricated object may have different abilities to immobilize, localize, and stabilize specific nutrients and chemical signals.

Abstract: Multiple colloids or hydrogels may each have a different chemical composition. A printer may extrude the colloids or hydrogels to form a physical object, in such a way that which hydrogel or colloid is deposited—or the amount of each hydrogel or colloid that is deposited—varies as a function of spatial position. Thus, the material composition and material properties of the physical object may vary at different locations. In some cases, physical properties of the structure being fabricated, such as surface roughness and hydrophilicity, are directly related to relative proportions of the materials being deposited and their fabrication processes. In some cases, cells, microorganisms, nutrients or other bioactive materials are embedded in or introduced to the fabricated structure. In some cases, the different materials in different spatial positions in the fabricated object may have different abilities to immobilize, localize, and stabilize specific nutrients and chemical signals.

Abstract: This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

Abstract: This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.