Patents by Inventor Joseph Holoshitz

Joseph Holoshitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small molecule inhibitors of shared epitope-calreticulin interactions and methods of use
    Patent number: 11613528
    Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a triazole-methyl-piperidinyl-pyrolyl-propenone structure which function as modulators of shared epitope (SE)—calreticulin (CRT) binding and/or interaction, and their use as therapeutics for the treatment of immunoregulatory abnormalities (e.g., autoimmune diseases, inflammatory diseases (e.g., chronic inflammatory disease), and bone erosive diseases) by selectively inhibiting SE-CRT interactions and/or signal transduction pathways commonly overactive or dysregulated in arthritic and/or other diseases or conditions.
    Type: Grant
    Filed: October 14, 2021
    Date of Patent: March 28, 2023
    Assignee: The Regents of the University of Michigan
    Inventors: Joseph Holoshitz, Andrew White
  • SMALL MOLECULE INHIBITORS OF SHARED EPITOPE-CALRETICULIN INTERACTIONS AND METHODS OF USE
    Publication number: 20220106292
    Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a triazole-methyl-piperidinyl-pyrolyl-propenone structure which function as modulators of shared epitope (SE)—calreticulin (CRT) binding and/or interaction, and their use as therapeutics for the treatment of immunoregulatory abnormalities (e.g., autoimmune diseases, inflammatory diseases (e.g., chronic inflammatory disease), and bone erosive diseases) by selectively inhibiting SE-CRT interactions and/or signal transduction pathways commonly overactive or dysregulated in arthritic and/or other diseases or conditions.
    Type: Application
    Filed: October 14, 2021
    Publication date: April 7, 2022
    Inventors: Joseph Holoshitz, Andrew White
  • Small molecule inhibitors of shared epitope-calreticulin interactions and methods of use
    Patent number: 11168071
    Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a triazole-methyl-piperidinyl-pyrolyl-propenone structure which function as modulators of shared epitope (SE)—calreticulin (CRT) binding and/or interaction, and their use as therapeutics for the treatment of immunoregulatory abnormalities (e.g., autoimmune diseases, inflammatory diseases (e.g., chronic inflammatory disease), and bone erosive diseases) by selectively inhibiting SE-CRT interactions and/or signal transduction pathways commonly overactive or dysregulated in arthritic and/or other diseases or conditions.
    Type: Grant
    Filed: June 9, 2020
    Date of Patent: November 9, 2021
    Assignee: The Regents of the University of Michigan
    Inventors: Joseph Holoshitz, Andrew White
  • SMALL MOLECULE INHIBITORS OF SHARED EPITOPE-CALRETICULIN INTERACTIONS AND METHODS OF USE
    Publication number: 20200299268
    Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a triazole-methyl-piperidinyl-pyrolyl-propenone structure which function as modulators of shared epitope (SE)—calreticulin (CRT) binding and/or interaction, and their use as therapeutics for the treatment of immunoregulatory abnormalities (e.g., autoimmune diseases, inflammatory diseases (e.g., chronic inflammatory disease), and bone erosive diseases) by selectively inhibiting SE-CRT interactions and/or signal transduction pathways commonly overactive or dysregulated in arthritic and/or other diseases or conditions.
    Type: Application
    Filed: June 9, 2020
    Publication date: September 24, 2020
    Inventors: Joseph Holoshitz, Andrew White
  • Small molecule inhibitors of shared epitope-calreticulin interactions and methods of use
    Patent number: 10723718
    Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a triazole-methyl-piperidinyl-pyrolyl-propenone structure which function as modulators of shared epitope (SE)-calreticulin (CRT) binding and/or interaction, and their use as therapeutics for the treatment of immunoregulatory abnormalities (e.g., autoimmune diseases, inflammatory diseases (e.g., chronic inflammatory disease), and bone erosive diseases) by selectively inhibiting SE-CRT interactions and/or signal transduction pathways commonly overactive or dysregulated in arthritic and/or other diseases or conditions.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: July 28, 2020
    Assignee: The Regents of the University of Michigan
    Inventors: Joseph Holoshitz, Andrew White
  • Methods and compositions for the treatment of arthritis
    Patent number: 10494405
    Abstract: The present disclosure relates to methods and compositions for treating disease related to disorders of bone remodeling. In particular, the present disclosure relates to cyclic peptide compositions and methods for treating rheumatoid arthritis.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: December 3, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Joseph Holoshitz, Katarzyna Sobczyk-Kojiro, Song Ling, Henry I. Mosberg
  • SMALL MOLECULE INHIBITORS OF SHARED EPITOPE-CALRETICULIN INTERACTIONS AND METHODS OF USE
    Publication number: 20190135783
    Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a triazole-methyl-piperidinyl-pyrolyl-propenone structure which function as modulators of shared epitope (SE)—calreticulin (CRT) binding and/or interaction, and their use as therapeutics for the treatment of immunoregulatory abnormalities (e.g., autoimmune diseases, inflammatory diseases (e.g., chronic inflammatory disease), and bone erosive diseases) by selectively inhibiting SE-CRT interactions and/or signal transduction pathways commonly overactive or dysregulated in arthritic and/or other diseases or conditions.
    Type: Application
    Filed: November 7, 2018
    Publication date: May 9, 2019
    Inventors: Joseph Holoshitz, Andrew White
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF ARTHRITIS
    Publication number: 20180291064
    Abstract: The present disclosure relates to methods and compositions for treating disease related to disorders of bone remodeling. In particular, the present disclosure relates to compositions and methods for treating rheumatoid arthritis.
    Type: Application
    Filed: May 13, 2016
    Publication date: October 11, 2018
    Inventors: Joseph HOLOSHITZ, Katarzyna SOBCZYK-KOJIRO, Song LING, Henry I. MOSBERG
  • Methods and compositions for the treatment of bone remodeling disorders
    Patent number: 9725484
    Abstract: The present invention relates to methods and compositions for treating disease related to disorders of bone remodeling. In particular, the present invention relates to compositions and methods for treating rheumatoid arthritis.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: August 8, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD.
    Inventors: Joseph Holoshitz, Song Ling, Chaim Gilon, Amnon Hoffman
  • Compositions and methods for inducing an immune response
    Patent number: 9555086
    Abstract: The present invention provides compositions and methods for inducing an immune response in a subject. In particular, the present invention provides compositions comprising immunostimulatory ligands (ISL) and methods of inducing an immune response in a subject therewith. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: January 31, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Joseph Holoshitz, Song Ling, Xiujun Pi, Denise de Almeida, Chaim Gilon, Amnon Hoffman
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF BONE REMODELING DISORDERS
    Publication number: 20160002295
    Abstract: The present invention relates to methods and compositions for treating disease related to disorders of bone remodeling. In particular, the present invention relates to compositions and methods for treating rheumatoid arthritis.
    Type: Application
    Filed: February 24, 2014
    Publication date: January 7, 2016
    Inventors: Joseph Holoshitz, Song Ling, Chaim Gilon, Amnon Hoffman
  • COMPOSITIONS AND METHODS FOR INDUCING AN IMMUNE RESPONSE
    Publication number: 20140212444
    Abstract: The present invention provides compositions and methods for inducing an immune response in a subject. In particular, the present invention provides compositions comprising immunostimulatory ligands (ISL) and methods of inducing an immune response in a subject therewith. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.
    Type: Application
    Filed: January 27, 2014
    Publication date: July 31, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Joseph Holoshitz, Song Ling, Xiujun Pi, Denise de Almeida, Chaim Gilon, Amnon Hoffman
  • Compositions and methods for inducing an immune response
    Patent number: 8658603
    Abstract: The present invention provides compositions and methods for inducing an immune response in a subject. In particular, the present invention provides compositions comprising immunostimulatory ligands (ISL) and methods of inducing an immune response in a subject therewith. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: February 25, 2014
    Assignee: The Regents of the University of Michigan
    Inventors: Joseph Holoshitz, Song Ling, Xiujun Pi, Denise de Almeida, Chaim Gilon, Amnon Hoffman
  • COMPOSITIONS AND METHODS FOR INDUCING AN IMMUNE RESPONSE
    Publication number: 20120141516
    Abstract: The present invention provides compositions and methods for inducing an immune response in a subject. In particular, the present invention provides compositions comprising immunostimulatory ligands (ISL) and methods of inducing an immune response in a subject therewith. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.
    Type: Application
    Filed: December 20, 2011
    Publication date: June 7, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Joseph Holoshitz, Song Ling, Xiujun Pi, Denise de Almeida
  • COMPOSITIONS AND METHODS FOR INDUCING AN IMMUNE RESPONSE
    Publication number: 20120034252
    Abstract: The present invention provides compositions and methods for inducing an immune response in a subject. In particular, the present invention provides compositions comprising immunostimulatory ligands (ISL) and methods of inducing an immune response in a subject therewith. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.
    Type: Application
    Filed: June 16, 2011
    Publication date: February 9, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Joseph Holoshitz, Song Ling, Xiujun Pi, Denise de Almeida
  • Methods and compositions for the treatment of MHC-associated conditions
    Patent number: 7208154
    Abstract: The present invention relates to methods and compositions for counteracting and reversing disease-causing signaling defects in disorders with underlying signal transduction aberrations, including but not limited to rheumatoid arthritis.
    Type: Grant
    Filed: May 13, 2004
    Date of Patent: April 24, 2007
    Assignee: Regents of the University of Michigan
    Inventors: Joseph Holoshitz, Song Ling
  • Methods and compositions for the treatment of diseases associated with signal transduction aberrations
    Patent number: 7074893
    Abstract: The present invention relates generally to therapeutic methods and compositions. More particularly, methods and compositions to counteract and reverse disease-causing signaling defects in diseases with underlying signal transduction aberrations, including but not limited to Alzheimer's Disease.
    Type: Grant
    Filed: February 25, 2004
    Date of Patent: July 11, 2006
    Assignee: Regents of the University of Michigan
    Inventors: Joseph Holoshitz, Song Ling
  • Method of treating oxidative stress-associated conditions with isopentenyl diphosphate
    Publication number: 20050215529
    Abstract: It has been found that isopentenyl diphosphate possesses antioxidant effects 1000 to 10,000 times more potent than classical antioxidants, such as ascorbic acid, ?-carotene, and ?-tocopherol, and 100 times more potent than 2-chloroadenosine. With such high potency, as disclosed herein, isopentenyl diphosphate can be used to treat or prevent one or more oxidative stress-associated conditions by administering to a host, and preferably a human being, in need thereof a therapeutically effective amount of a pharmaceutical composition containing isopentenyl diphosphate or a pharmaceutically acceptable salt thereof. Additionally, isopentenyl diphosphate can be used to treat or prevent oxidative stress-associated damage to a biomolecule by administering isopentenyl diphosphate or a pharmaceutically acceptable salt thereof to the biomolecule.
    Type: Application
    Filed: March 21, 2005
    Publication date: September 29, 2005
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Joseph Holoshitz, Jie Zheng
  • Methods and compositions for the treatment of MHC-associated conditions
    Publication number: 20050013820
    Abstract: The present invention relates to methods and compositions for counteracting and reversing disease-causing signaling defects in disorders with underlying signal transduction aberrations, including but not limited to rheumatoid arthritis.
    Type: Application
    Filed: May 13, 2004
    Publication date: January 20, 2005
    Applicant: The Regents of the University of Michigan
    Inventors: Joseph Holoshitz, Song Ling
  • Methods and compositions for the treatment of diseases associated with signal transduction aberrations
    Publication number: 20040236071
    Abstract: The present invention relates generally to therapeutic methods and compositions. More particularly, methods and compositions to counteract and reverse disease-causing signaling defects in diseases with underlying signal transduction aberrations, including but not limited to Alzheimer's Disease.
    Type: Application
    Filed: February 25, 2004
    Publication date: November 25, 2004
    Applicant: The Regents Of The University Of Michigan
    Inventors: Joseph Holoshitz, Song Ling