Abstract: Novel compounds for treating or inhibiting leishmaniasis and other parasitic protozoan diseases are disclosed herein. The compounds bind to Leishmania tubulin, induce parasite microtubule polymerization, stall Leishmania cell division, and have broad antiparasitic activity.

Abstract: Systems that include integrated circuit dies and voltage regulator units are disclosed. Such systems may include a voltage regulator module and an integrated circuit mounted in a common system package. The voltage regulator module may include a voltage regulator circuit and one or more passive devices mounted to a common substrate, and the integrated circuit may include a System-on-a-chip. The system package may include an interconnect region that includes wires fabricated on multiple conductive layers within the interconnect region. At least one power supply terminal of the integrated circuit may be coupled to an output of the voltage regulator module via a wire included in the interconnect region.

Abstract: A medical device, such as a neurostimulator, is provided that includes a housing, a power supply, a signal generator and one or more electrodes coupled to the housing. The signal generator is configured to apply one or more electrical impulses to the one or more electrodes for a period of time, the period of time being defined as a single dose. The device is configured to switch from an activated mode and a deactivated mode after specific number of single doses have been emitted by the signal generator.

Abstract: A system and method is provided for controlling an acquisition system to obtain, based on a currently acquired set of projection data, a next set of projection data that is to be acquired using a set of learned imaging conditions. The set of learned imaging conditions are, at least in part, based on training data including projection data and dose information. In one embodiment, the initial dose and angle for obtaining the initial set of projection data are chosen at random. In another embodiment, the initial dose and angle for obtaining the initial set of projection data are chosen based on a test scan and a trained neural network for outputting the initial dose and angle using a loss function.

Abstract: Generally, an integrated circuit, an apparatus and a method for buffering analog information capture first analog information with a capture element and store at least portions of the analog information in a first passive variable resistance memory element coupled to the capture element and in a second passive variable resistance memory element. The portions of the analog information stored in the first passive variable resistance memory element and in the second passive variable resistance memory element may be the same or may be different.

Abstract: Generally, an integrated circuit, an apparatus and a method for buffering analog information capture first analog information with a capture element and store at least portions of the analog information in a first passive variable resistance memory element coupled to the capture element and in a second passive variable resistance memory element. The portions of the analog information stored in the first passive variable resistance memory element and in the second passive variable resistance memory element may be the same or may be different.