Patents by Inventor Joseph I. DeGraw, Jr.

Joseph I. DeGraw, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phenoxy alkanol esters for treatment of allergic conditions
    Patent number: 5242936
    Abstract: Compounds of the formula: ##STR1## wherein R.sub.1 is at position 4 and either is an alkyl group of 1-6 C or is an --(CH.sub.2).sub.3 -- which is additionally linked to the phenyl at position 3 thereof;R.sub.2 is a lower alkyl of 1-3 C or is hydrogen;n.sub.1, n.sub.2 and n.sub.3 represent the number of CH.sub.2, C(R.sub.2).sub.2 and CH.sub.2 groups, respectively, wherein n.sub.1 is 2, 3, 4, 5, 6, 8, or 11, n.sub.2 is 0 or 1 and n.sub.3 is 0 andR.sub.4 is an alkyl residue of 1-12 C or is selected from phenyl and pyridyl; and their pharmaceutical compositions are useful in inhibiting the release of chemical mediators which cause allergic symptoms. Compounds, compositions, and methods for treatment of allergic conditions are disclosed.
    Type: Grant
    Filed: May 21, 1990
    Date of Patent: September 7, 1993
    Assignee: Frank M. Berger
    Inventors: Frank M. Berger, Joseph I. DeGraw, Jr., Howard L. Johnson
  • P-alkyl phenoxy alkanols for the treatment of allergic conditions
    Patent number: 5021460
    Abstract: p-Alkyl or cycloalkyl phenoxy alkanols and esters are provided having the structure: ##STR1## in which: R.sub.1 is an alkyl group having from one to six carbon atoms, preferably tertiary, and still more preferably tertiary-butul; or a bivalent cycloalkylene group condensed with the phenyl group at adjacent ring carbons thereof, such as in indane;R.sub.2 is lower alkyl having from one to three carbon atoms or hydrogen;R.sub.3 is hydroxyl or an ester group selected from the group consisting of COOR.sub.4 and OOCR.sub.4 derived from unsubstituted and hydroxy-substituted monocarboxylic acids and COOR.sub.5 OOC and OOCR.sub.
    Type: Grant
    Filed: December 22, 1988
    Date of Patent: June 4, 1991
    Assignee: Frank M. Berger
    Inventors: Frank M. Berger, Howard L. Johnson, Joseph I. DeGraw, Jr.
  • Process and composition for treatment of luekemia and process for preparing the same
    Patent number: 4753939
    Abstract: A process and composition are provided employing 10-ethyl- 10 deazaminopterin for treating leukemia, as well as other tumor systems including of ascitic character.
    Type: Grant
    Filed: June 5, 1986
    Date of Patent: June 28, 1988
    Assignees: SRI International, Sloan Kettering Institute for Cancer Research
    Inventors: Joseph I. DeGraw, Jr., Francis M. Sirotnak
  • P-Alkyl or cycloalkyl phenoxy alkanols and alkanol esters and process for the treatment of allergic conditions
    Patent number: 4543362
    Abstract: p-Alkyl or cycloalkyl phenoxy alkanols and esters are provided having the structure: ##STR1## in which: R.sub.1 is an alkyl group having from one to six carbon atoms, preferably tertiary, and still more preferably tertiary-butyl; or a bivalent cycloalkylene group condensed with the phenyl group at adjacent ring carbons thereof, such as in indane;R.sub.2 is lower alkyl having from one to three carbon atoms or hydrogen;R.sub.3 is hydroxyl or an ester group selected from the group consisting of COOR.sub.4 and OOCR.sub.4 derived from unsubstituted and hydroxy-substituted monocarboxylic acids and COOR.sub.5 OOC and OOCR.sub.
    Type: Grant
    Filed: January 13, 1984
    Date of Patent: September 24, 1985
    Assignee: Frank M. Berger
    Inventors: Frank M. Berger, Joseph I. DeGraw, Jr., Howard L. Johnson
  • T-Butyl-phenoxy-alkylene esters of benzoic and nicotinic acids, compositions containing same and their antihistaminic method of use
    Patent number: 4451474
    Abstract: p-Alkyl or cycloalkyl phenoxy alkanols and esters are provided having the structure: ##STR1## in which: R.sub.1 is an alkyl group having from one to six carbon atoms, preferably tertiary, and still more preferably tertiary-butyl; or a bivalent cycloalkylene group condensed with the phenyl group at adjacent ring carbons thereof, such as in indane;R.sub.2 is lower alkyl having from one to three carbon atoms or hydrogen;R.sub.3 is hydroxyl or an ester group selected from the group consisting of COOR.sub.4 and OOCR.sub.4 derived from unsubstituted and hydroxy-substituted monocarboxylic acids and COOR.sub.5 OOC and OOCR.sub.
    Type: Grant
    Filed: December 3, 1981
    Date of Patent: May 29, 1984
    Assignee: Frank M. Berger
    Inventors: Frank M. Berger, Joseph I. DeGraw, Jr., Howard L. Johnson
  • Process for preparing 10-deazaminopterins
    Patent number: 4433147
    Abstract: A process and composition are provided employing 10-deazaminopterin and 10-alkyl derivatives therefor for the treatment of leukemia, as well as other tumor systems including those of ascitic character, and also a process for preparing 10-deazaminopterin compounds.
    Type: Grant
    Filed: January 22, 1982
    Date of Patent: February 21, 1984
    Inventors: Joseph I. DeGraw, Jr., Francis M. Sirotnak
  • Process and composition for treatment of leukemia and process for preparing the same
    Patent number: 4393064
    Abstract: A process and composition are provided employing 10-deazaminopterin for treating leukemia and ascites tumor.
    Type: Grant
    Filed: September 17, 1979
    Date of Patent: July 12, 1983
    Assignees: SRI International, Sloan Kettering Institute for Cancer Research
    Inventors: Joseph I. DeGraw, Jr., Francis M. Sirotnak
  • 10-Alkyl-10-deazaminopterins
    Patent number: 4369319
    Abstract: A process and composition are provided employing 10-deazaminopterin and 10-alkyl derivatives thereof for the treatment of leukemia, as well as other tumor systems including those of ascitic character, and also a process for preparing 10-deazaminopterin compounds.
    Type: Grant
    Filed: February 10, 1981
    Date of Patent: January 18, 1983
    Inventors: Joseph I. DeGraw, Jr., Francis M. Sirotnak