Patents by Inventor Joseph I. Shapiro

Joseph I. Shapiro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Na/K-ATPase Ligand
    Publication number: 20140128356
    Abstract: Methods and compositions for detecting, treating, characterizing, and diagnosing interstitial lung and/or fibrotic diseases are described.
    Type: Application
    Filed: March 25, 2013
    Publication date: May 8, 2014
    Applicant: The University of Toledo
    Inventors: Zi-Jian Xie, Joseph I. Shapiro
  • Na/K-ATPase Ligands, Ouabain Antagonists, Assays and Uses Thereof
    Publication number: 20140031419
    Abstract: The present disclosure relates to methods of inhibiting the ATPase activity of Na/K-ATPase without stimulating the receptor function, methods of blocking Na/K-ATPase interaction with Src, methods of inhibiting cell growth, and methods of abolishing ouabain-provoked signaling transduction in the heart of a subject, which includes providing an effective amount of at least one hydroxyl xanthone derivative.
    Type: Application
    Filed: October 3, 2013
    Publication date: January 30, 2014
    Applicant: The University of Toledo
    Inventors: Zi-Jian Xie, Joseph I. Shapiro, Shuyi Si, Zhongbing Zhang
  • Na/K-ATPase Ligands, Ouabain Antagonists, Assays and Uses Thereof
    Publication number: 20120302630
    Abstract: Na/K-ATPase/Src ligands, assays and uses thereof are disclosed.
    Type: Application
    Filed: September 9, 2010
    Publication date: November 29, 2012
    Applicants: CHINESE ACADEMY OF MEDICAL SCIENCES, UNIVERSITY OF TOLEDO
    Inventors: Zi-Jian Xie, Joseph I. Shapiro, Shuyi Si, Zhongbing Zhang
  • Na+K+-ATPase-specific peptide inhibitors/activators of SRC and SRC family kinases
    Patent number: 8283441
    Abstract: A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: October 9, 2012
    Assignee: University of Toledo
    Inventors: Zijian Xie, Joseph I. Shapiro, Jiang Tian
  • Peg-albumin composition having at least one protected thiol region as a platform for medications
    Publication number: 20120010144
    Abstract: This composition comprises a polyethylene glycol-albumin composition having at least one protected thiol region wherein the composition comprises PEG-AlbCys34 with Cys-34 preserved as a thiol. The albumin is linked to medications such as, antioxidants with a reduced sulfhydryl group through the Cys 34 residing on the albumin. The compositions are useful in treating patients.
    Type: Application
    Filed: April 2, 2010
    Publication date: January 12, 2012
    Inventors: Ragheb Assaly, John David Digman, Joseph I Shapiro
  • NaK-ATPase-Derived Peptide SRC Inhibitors and Ouabain Antagonists and Uses Thereof
    Publication number: 20110245167
    Abstract: A novel Src inhibitor that targets the Na/K-ATPase/Src receptor complex and antagonizes ouabain-induced protein kinase cascades and uses thereof are disclosed.
    Type: Application
    Filed: December 14, 2009
    Publication date: October 6, 2011
    Applicant: THE UNIVERSITY OF TOLEDO
    Inventors: Zi-Jian Xie, Zhichuan Li, Joseph I. Shapiro
  • Albumin-based colloid composition having at least one protected thiol region, methods of making, and methods of use
    Patent number: 7884068
    Abstract: A composition comprising an albumin-based colloid composition having at least one protected thiol region, method of making the same, and method for use, including treating hypovolemic conditions such as capillary leak syndrome and shock, are disclosed.
    Type: Grant
    Filed: November 9, 2004
    Date of Patent: February 8, 2011
    Inventors: Ragheb A. Assaly, J. David Dignam, Joseph I. Shapiro
  • NA+K+-ATPase-Specific Peptide Inhibitors/Activators of SRC and SRC Family Kinases
    Publication number: 20100056446
    Abstract: A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific.
    Type: Application
    Filed: October 31, 2007
    Publication date: March 4, 2010
    Applicant: THE UNIVERSITY OF TOLEDO
    Inventors: Zijian Xie, Joseph I. Shapiro, Jiang Tian
  • Albumin-based colloid composition and method of use in treating hypovolemia and multiorgan dysfunction
    Publication number: 20100004178
    Abstract: A composition comprising an albumin-based colloid and its use in treating hypovolemic conditions such as capillary leak syndrome and shock are disclosed.
    Type: Application
    Filed: September 10, 2009
    Publication date: January 7, 2010
    Inventors: Ragheb Assaly, John D. Dignam, Joseph I. Shapiro
  • Albumin-based colloid composition and method of use in treating hypovolemia and multiorgan dysfunction
    Patent number: 7605130
    Abstract: A composition comprising an albumin-based colloid and its use in treating hypovolemic conditions such as capillary leak syndrome and shock are disclosed.
    Type: Grant
    Filed: November 6, 2007
    Date of Patent: October 20, 2009
    Assignee: Medical College of Ohio
    Inventors: Ragheb Assaly, John D. Dignam, Joseph I. Shapiro
  • Na/K-ATpase Ligand
    Publication number: 20090226513
    Abstract: This process relates to a pharmaceutical composition of an Na-K-ATPase ligand which will stimulate Na/K-ATPase signaling in a pharmaceutically acceptable vehicle. In one embodiment, the composition may be used to treat a skin disorder. In another embodiment, the composition may be used to inhibit cardiac fibrosis.
    Type: Application
    Filed: January 30, 2007
    Publication date: September 10, 2009
    Inventors: Zijian Xie, Joseph I. Shapiro
  • Albumin-based colloid composition having at least one protected thiol region, methods of making, and methods of use
    Publication number: 20080247958
    Abstract: A composition comprising an albumin-based colloid composition having at least one protected thiol region, method of making the same, and method for use, including treating hypovolemic conditions such as capillary leak syndrome and shock, are disclosed. The composition also is modified with an indicator reagent such as chromophores.
    Type: Application
    Filed: January 22, 2008
    Publication date: October 9, 2008
    Inventors: Ragheb A. Assaly, J. David Dignam, Joseph I. Shapiro
  • Albumin-based colloid composition and method of use in treating hypovolemia and multiorgan dysfunction
    Patent number: 7348312
    Abstract: A composition comprising an albumin-based colloid and its use in treating hypovolemic conditions such as capillary leak syndrome and shock are disclosed.
    Type: Grant
    Filed: March 22, 2006
    Date of Patent: March 25, 2008
    Assignee: Medical College of Ohio
    Inventors: Ragheb Assaly, John D. Dignam, Joseph I. Shapiro
  • Albumin-based colloid composition having at least one protected thiol region, methods of making, and methods of use
    Patent number: 7345150
    Abstract: A composition comprising an albumin-based colloid composition having at least one protected thiol region, method of making the same, and method for use, including treating hypovolemic conditions such as capillary leak syndrome and shock, are disclosed. The composition also is modified with an indicator reagent such as chromophores.
    Type: Grant
    Filed: October 25, 2005
    Date of Patent: March 18, 2008
    Assignee: Medical University of Toledo
    Inventors: Ragheb A. Assaly, J. David Dignam, Joseph I. Shapiro
  • Albumin-based colloid composition and method of use in treating hypovolemia and multiorgan dysfunction
    Patent number: 7037895
    Abstract: A composition comprising an albumin-based colloid and its use in treating hypovolemic conditions such as capillary leak syndrome and shock are disclosed.
    Type: Grant
    Filed: March 26, 2002
    Date of Patent: May 2, 2006
    Assignee: Medical College of Ohio
    Inventors: Ragheb Assaly, John D. Dignam, Joseph I. Shapiro
  • Albumin-based colloid composition and method of use in treating hypovolemia and multiorgan dysfunction
    Publication number: 20030004105
    Abstract: A composition comprising an albumin-based colloid and its use in treating hypovolemic conditions such as capillary leak syndrome and shock are disclosed.
    Type: Application
    Filed: March 26, 2002
    Publication date: January 2, 2003
    Inventors: Ragheb A. Assaly, John D. Dignam, Joseph I. Shapiro