Patents by Inventor Joseph Italiano
Joseph Italiano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11850589Abstract: A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.Type: GrantFiled: June 24, 2022Date of Patent: December 26, 2023Assignees: The Brigham and Women's Hospital, Inc., Boston, MA;, President and Fellows of Harvard College, Vilnius UniversityInventors: Joseph Italiano, Linas Mazutis, Jonathan N. Thon, David A. Weitz
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Publication number: 20230009208Abstract: A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.Type: ApplicationFiled: June 24, 2022Publication date: January 12, 2023Inventors: Joseph Italiano, Linas Mazutis, Jonathan N. Thon, David A. Weitz
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Patent number: 11396016Abstract: A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.Type: GrantFiled: June 17, 2020Date of Patent: July 26, 2022Assignees: The Brigham and Women's Hospital, Inc., President and Fellows of Harvard College, Vilnius UniversityInventors: Joseph Italiano, Linas Mazutis, Jonathan Thon, David A. Weitz
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Publication number: 20200316597Abstract: A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.Type: ApplicationFiled: June 17, 2020Publication date: October 8, 2020Inventors: Joseph Italiano, Linas Mazutis, Jonathan Thon, David A. Weitz
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Patent number: 10710073Abstract: A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.Type: GrantFiled: May 24, 2019Date of Patent: July 14, 2020Assignees: Brigham and Women's Hospital, Inc., President and Fellows of Harvard College, Vilnius UniversityInventors: Joseph Italiano, Linas Mazutis, Jonathan N. Thon, David A. Weitz
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Publication number: 20190283027Abstract: A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.Type: ApplicationFiled: May 24, 2019Publication date: September 19, 2019Inventors: Joseph Italiano, Linas Mazutis, Jonathan N. Thon, David A. Weitz
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Patent number: 10343163Abstract: A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.Type: GrantFiled: September 20, 2017Date of Patent: July 9, 2019Assignees: The Brigham and Women's Hospital, Inc., President and Fellows of Harvard College, Vilnius UniversityInventors: Joseph Italiano, Linas Mazutis, Jonathan N. Thon, David A. Weitz
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Publication number: 20180021780Abstract: A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.Type: ApplicationFiled: September 20, 2017Publication date: January 25, 2018Inventors: Joseph Italiano, Linas Mazutis, Jonathan N. Thon, David A. Weitz
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Patent number: 9795965Abstract: A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.Type: GrantFiled: November 20, 2013Date of Patent: October 24, 2017Assignee: Brigham and Women's Hospital, Inc.Inventors: Joseph Italiano, Linas Mazutis, Jonathan N. Thon, David A. Weitz
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Publication number: 20150336095Abstract: A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.Type: ApplicationFiled: November 20, 2013Publication date: November 26, 2015Inventors: Joseph Italiano, Linas Mazutis, Jonathan N. Thon, David A. Weitz
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Publication number: 20130177928Abstract: Described herein are methods useful for normalizing any biomarker in platelets. This has application in any method in which one wishes to ascertain or compare the level of a biomarker, e.g., for diagnostic or prognostic methods relating to a biomarker of interest. Using such an approach can permit the assessment of disease status (e.g., angiogenic status) of an individual with less error than an expression value that is not normalized or that is normalized to total protein levels. Also provided are methods for selecting a normalizing protein for normalizing biomarkers in a sample, e.g., a platelet sample.Type: ApplicationFiled: November 23, 2010Publication date: July 11, 2013Applicants: THE NEWMAN-LAKKA CANCER FOUNDATION, THE BRIGHAM AND WOMEN'S HOSPITAL, INC., ORTHO-CLINICAL DIAGNOSTICS, INC.Inventors: Jon Peterson, Giannoula Klement, Joseph Italiano, Sean Downing
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Patent number: 7816236Abstract: Chemical vapor deposition methods use trisilane and a halogen-containing etchant source (such as chlorine) to selectively deposit Si-containing films over selected regions of mixed substrates. Dopant sources may be intermixed with the trisilane and the etchant source to selectively deposit doped Si-containing films. The selective deposition methods are useful in a variety of applications, such as semiconductor manufacturing.Type: GrantFiled: January 30, 2006Date of Patent: October 19, 2010Assignee: ASM America Inc.Inventors: Matthias Bauer, Chantal Arena, Ronald Bertram, Pierre Tomasini, Nyles Cody, Paul Brabant, Joseph Italiano, Paul Jacobson, Keith Doran Weeks
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Publication number: 20070224786Abstract: Methods for depositing epitaxial films such as epitaxial Ge and SiGe films. During cooling from high temperature processing to lower deposition temperatures for Ge-containing layers, Si or Ge compounds are provided to the substrate. Smooth, thin, relatively defect-free Ge or SiGe layers result. Retrograded relaxed SiGe is also provided between a relaxed, high Ge-content seed layer and an overlying strained layer.Type: ApplicationFiled: May 30, 2007Publication date: September 27, 2007Applicant: ASM AMERICA, INC.Inventors: Paul Brabant, Joseph Italiano, Chantal Arena, Pierre Tomasini, Ivo Raaijmakers, Matthias Bauer
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Publication number: 20060281322Abstract: Methods for depositing epitaxial films such as epitaxial Ge and SiGe films. During cooling from high temperature processing to lower deposition temperatures for Ge-containing layers, Si or Ge compounds are provided to the substrate. Smooth, thin, relatively defect-free Ge or SiGe layers result. Retrograded relaxed SiGe is also provided between a relaxed, high Ge-content seed layer and an overlying strained layer.Type: ApplicationFiled: August 18, 2006Publication date: December 14, 2006Inventors: Paul Brabant, Joseph Italiano, Chantal Arena, Pierre Tomasini, Ivo Raaijmakers, Matthias Bauer
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Publication number: 20060234504Abstract: Chemical vapor deposition methods use trisilane and a halogen-containing etchant source (such as chlorine) to selectively deposit Si-containing films over selected regions of mixed substrates. Dopant sources may be intermixed with the trisilane and the etchant source to selectively deposit doped Si-containing films. The selective deposition methods are useful in a variety of applications, such as semiconductor manufacturing.Type: ApplicationFiled: January 30, 2006Publication date: October 19, 2006Inventors: Matthias Bauer, Chantal Arena, Ronald Bertram, Pierre Tomasini, Nyles Cody, Paul Brabant, Joseph Italiano, Paul Jacobson, Keith Weeks
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Publication number: 20050193952Abstract: A substrate support system comprises a relatively thin circular substrate holder having a plurality of passages extending between top and bottom surfaces thereof. The substrate holder includes a single substrate support ledge or a plurality of substrate support spacer vanes configured to support a peripheral portion of the substrate backside so that a thin gap is formed between the substrate and the substrate holder. The vanes can be angled to resist backside deposition of reactant gases as the substrate holder is rotated. A hollow support member provides support to an underside of the substrate holder. The hollow support member is configured to convey gas (e.g., inert gas or cleaning gas) upward into one or more of the passages of the substrate holder. The upwardly conveyed gas flows into the gap between the substrate and the substrate holder.Type: ApplicationFiled: February 11, 2005Publication date: September 8, 2005Inventors: Matt Goodman, Jereon Stoutyesdijk, Ravinder Aggarwal, Mike Halpin, Tony Keeton, Mark Hawkins, Lee Haen, Armand Ferro, Paul Brabant, Robert Vyne, Gregory Bartlett, Joseph Italiano, Bob Haro
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Publication number: 20050092235Abstract: Methods for depositing epitaxial films such as epitaxial Ge and SiGe films. During cooling from high temperature processing to lower deposition temperatures for Ge-containing layers, Si or Ge compounds are provided to the substrate. Smooth, thin, relatively defect-free Ge or SiGe layers result. Retrograded relaxed SiGe is also provided between a relaxed, high Ge-content seed layer and an overlying strained layer.Type: ApplicationFiled: November 18, 2004Publication date: May 5, 2005Inventors: Paul Brabant, Joseph Italiano, Chantal Arena, Pierre Tomasini, Ivo Raaijmakers, Matthias Bauer