Patents by Inventor Joseph J. Barchi, Jr.

Joseph J. Barchi, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BIOFUNCTIONALIZED QUANTUM DOTS FOR BIOLOGICAL IMAGING
    Publication number: 20110033954
    Abstract: Novel biofunctionalized quantum dots include a mercaptoalkanoic acid linked to the surface of a nanocrystalline core and a biofunctional group linked to the surface. Biofunctionalized quantum dots are made by a novel synthesis method. Biofunctionalized quantum dots can be used in imaging or therapy applications.
    Type: Application
    Filed: July 28, 2010
    Publication date: February 10, 2011
    Applicant: The Government of the United State of America, as Represented by the Secretary, Department of Health
    Inventors: Joseph J. Barchi, JR., Serge A. Svarovsky
  • Biofunctionalized quantum dots for biological imaging
    Patent number: 7790473
    Abstract: Novel biofunctionalized quantum dots include a mercaptoalkanoic acid linked to the surface of a nanocrystalline core and a bio-functional group linked to the surface. Biofunctionalized quantum dots are made by a novel synthesis method. Biofunctionalized quantum dots can be used in imaging or therapy applications.
    Type: Grant
    Filed: November 5, 2003
    Date of Patent: September 7, 2010
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Joseph J. Barchi, Jr., Sergei A. Svarovsky
  • Conformationally locked nucleoside analogues
    Patent number: 5869666
    Abstract: Conformationally locked 4',6'-cyclopropane-fused carboxylic nucleoside analogues. The compounds are prepared by condensing a cyclopropane-fused carbocyclic allylic alcohol with substituted purine or pyrimidine bases. The condensation products are then modified to produce the adenosine, guanosine, cytidine, thymidine, and uracil nucleoside analogues. The compounds are therapeutically useful as antimetabolites, or in the preparation of anti-metabolic agents.
    Type: Grant
    Filed: March 14, 1997
    Date of Patent: February 9, 1999
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Victor E. Marquez, Juan B. Rodriguez, Marc C. Nicklaus, Joseph J. Barchi, Jr., Maqbool A. Siddiqui
  • Conformationally locked nucleoside analogs as antiherpetic agents
    Patent number: 5840728
    Abstract: A method for treatment of herpes virus infection by administering an effective virus-inhibiting amount of a cyclopropanated carbocyclic 2'-deoxynucleoside to an individual in need thereof. The nucleoside analogs are effective against herpes simplex virus types 1 and 2; Epstein-Barr Virus and human cytomegalovirus.
    Type: Grant
    Filed: August 7, 1997
    Date of Patent: November 24, 1998
    Assignee: United States of America as represented by the Department of Health and Human services
    Inventors: Victor E. Marquez, Marc C. Nicklaus, Joseph J. Barchi, Jr., Juan B. Rodriguez, Maqbool Siddiqui
  • Conformationally locked nucleoside analogues
    Patent number: 5629454
    Abstract: Conformationally locked 4',6'-cyclopropane-fused carbocyclic nucleoside analogues. The compounds are prepared by condensing a cyclopropane-fused carbocyclic allylic alcohol with substituted purine or pyrimidine bases. The condensation products are then modified to produce the adenosine, guanosine, cytidine, thymidine and uracil nucleoside analogues. The compounds are therapeutically useful as antimetabolites, or in the preparation of anti-metabolic agents.
    Type: Grant
    Filed: September 23, 1994
    Date of Patent: May 13, 1997
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Victor E. Marquez, Juan B. Rodriguez, Marc C. Nicklaus, Joseph J. Barchi, Jr., Maqbool A. Siddiqui
  • Lipophilic, aminohydrolase-activated prodrugs
    Patent number: 5459256
    Abstract: The present invention relates, in general, to prodrugs. In particular, the present invention relates to lipophilic, aminohydrolase-activated, anti-viral nucleoside prodrug compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds.
    Type: Grant
    Filed: April 10, 1991
    Date of Patent: October 17, 1995
    Assignee: The Government of the United States of America as represented by the Department of Health and Human Services
    Inventors: Victor E. Marquez, John S. Driscoll, Harry Ford, Jr., James A. Kelley, Joseph J. Barchi, Jr., Hiroaki Mitsuya, Christopher K-H. Tseng, David G. Johns, Joseph E. Tomaszewski