Abstract: Anti-biofilm osseointegrating and/or tissue-integrating implantable biomaterial devices that optionally can elute therapeutic ions such as magnesium, silver, copper and/or zinc. In certain embodiments, the devices are engineered to produce structures suitable as implants having a relatively high surface population of zeolite. Methods of producing the devices are also disclosed.

Abstract: Anti-biofilm osseointegrating and/or tissue-integrating implantable biomaterial devices that optionally can elute therapeutic ions such as magnesium, silver, copper and/or zinc. In certain embodiments, the devices are engineered to produce structures suitable as implants having a relatively high surface population of zeolite. Methods of producing the devices are also disclosed.

Abstract: Methods of post-loading ceramic particles with antimicrobial metal cations are disclosed. In certain embodiments, the post-loaded particles are zeolites, wherein the zeolites have been incorporated into a resin and the combination is used as an implantable device. In certain embodiments, the polymer is a thermoplastic polymer such as polyaryletheretherketone (PEEK). In certain embodiments, the source of antimicrobial activity includes ion-exchangeable cations contained in a zeolite. In certain embodiments, disclosed are methods of imparting antimicrobial activity to devices by controlling the delivery of certain cations through ion-exchange via a zeolite incorporated in the device.

Abstract: Methods of post-loading ceramic particles with antimicrobial metal cations are disclosed. In certain embodiments, the post-loaded particles are zeolites, wherein the zeolites have been incorporated into a resin and the combination is used as an implantable device. In certain embodiments, the polymer is a thermoplastic polymer such as polyaryletheretherketone (PEEK). In certain embodiments, the source of antimicrobial activity includes ion-exchangeable cations contained in a zeolite. In certain embodiments, disclosed are methods of imparting antimicrobial activity to devices by controlling the delivery of certain cations through ion-exchange via a zeolite incorporated in the device.

Abstract: Anti-biofilm osseointegrating implantable devices are made by additive manufacturing. A powder formulation is made that includes a resin such as a polyarylether ketone such as PEEK, and a zeolite, and the zeolite may be loaded with one or more therapeutic metal ions, such as silver, copper and/or zinc that exhibit antimicrobial properties. The powder formulation also may include a porogen to control the porosity of the resulting three-dimensional implant device. The devices, which are osseointegrating, may include metal-loaded zeolite so as to elute antimicrobial metal ions in a therapeutically effective amount when implanted into a body and exposed to bodily fluid.

Abstract: Anti-biofilm osseointegrating implantable devices that can elute therapeutic ions such as silver are provided by powder coating implantable substrates such as metal substrates. The polymer includes a polyarylether ketone such as PEEK, and zeolite, and the zeolite may be loaded with one or more therapeutic metal ions, such as silver, copper and/or zinc that exhibit antimicrobial properties. The devices, when implanted into a body and exposed to bodily fluid, may elute antimicrobial metal ions in a therapeutically effective amount.

Abstract: Anti-biofilm osseointegrating implantable devices are made by additive manufacturing. A powder formulation is made that includes a resin such as a polyarylether ketone such as PEEK, and a zeolite, and the zeolite may be loaded with one or more therapeutic metal ions, such as silver, copper and/or zinc that exhibit antimicrobial properties. The powder formulation also may include a porogen to control the porosity of the resulting three-dimensional implant device. The devices, which are osseointegrating, may include metal-loaded zeolite so as to elute antimicrobial metal ions in a therapeutically effective amount when implanted into a body and exposed to bodily fluid.

Abstract: Methods of post-loading ceramic particles with antimicrobial metal cations are disclosed. In certain embodiments, the post-loaded particles are zeolites, wherein the zeolites have been incorporated into a resin and the combination is used as an implantable device. In certain embodiments, the polymer is a thermoplastic polymer such as polyaryletheretherketone (PEEK). In certain embodiments, the source of antimicrobial activity includes ion-exchangeable cations contained in a zeolite. In certain embodiments, disclosed are methods of imparting antimicrobial activity to devices by controlling the delivery of certain cations through ion-exchange via a zeolite incorporated in the device.

Abstract: Methods of post-loading ceramic particles with antimicrobial metal cations are disclosed. In certain embodiments, the post-loaded particles are zeolites, wherein the zeolites have been incorporated into a resin and the combination is used as an implantable device. In certain embodiments, the polymer is a thermoplastic polymer such as polyaryletheretherketone (PEEK). In certain embodiments, the source of antimicrobial activity includes ion-exchangeable cations contained in a zeolite. In certain embodiments, disclosed are methods of imparting antimicrobial activity to devices by controlling the delivery of certain cations through ion-exchange via a zeolite incorporated in the device.

Abstract: A method of controlling pathogenic fusarium fungi in agriculture through the application of a bioactive composition comprising a) an organic acid, b) at least one antimicrobial metal ion or ion source, and c) optionally, at least one surfactant.

Abstract: Seeds having applied to their surface a bioactive agrichemical composition comprising metal-acid solutions for protecting the seed from the adverse action of microorganisms.

Abstract: Methods of fabricating implantable medical devices, preferably with PEEK, having antimicrobial properties, are disclosed. The antimicrobial effect is produced by incorporating ceramic particles containing antimicrobial metal cations into molten PEEK resin, which is subsequently allowed to cool and set in its final shape achieved by injection molding, cutting and machining or other techniques.

Abstract: Seeds having applied to their surface a bioactive agrichemical composition comprising metal-acid solutions for protecting the seed from the adverse action of microorganisms.

Abstract: Bioactive agrichemical concentrates and compositions having improved bioactivity comprising combinations of acid solutions and conventional bioactive agrichemical actives or formulations.

Abstract: Keratinous fiber treatment formulations and methods of providing a long lasting set in keratinous fibers such as hair by applying a polymer system to the hair which provides a stable set to the hair which will last at least until the hair is thoroughly washed. The set is made more permanent by incorporating a reducing agent such as L-cysteine into the polymer system and allowing the system to air oxidize over time or optionally applying a second chemical oxidizing system to the treated hair which will accelerate the oxidation process and the setting rate of the hair.

Abstract: Methods of fabricating implantable medical devices, preferably with PEEK, having antimicrobial properties, are disclosed. The antimicrobial effect is produced by incorporating ceramic particles containing antimicrobial metal cations into molten PEEK resin, which is subsequently allowed to cool and set in its final shape achieved by injection molding, cutting and machining or other techniques.

Abstract: A method of protecting food or delaying the onset of food spoilage said method comprising applying a protective bioactive composition to the food or the packing or packaging in which the food is stored.

Abstract: Methods of fabricating implantable medical devices, preferably with PEEK, having antimicrobial properties, are disclosed. The antimicrobial effect is produced by incorporating ceramic particles containing antimicrobial metal cations into molten PEEK resin, which is subsequently allowed to cool and set in its final shape achieved by injection molding, cutting and machining or other techniques.

Abstract: Methods of fabricating implantable medical devices, preferably with PEEK, having antimicrobial properties, are disclosed. The antimicrobial effect is produced by incorporating ceramic particles containing antimicrobial metal cations into molten PEEK resin, which is subsequently allowed to cool and set in its final shape achieved by injection molding, cutting and machining or other techniques.

Abstract: Bioactive agrichemical concentrates and compositions having improved bioactivity comprising combinations of acid solutions and conventional bioactive agrichemical actives or formulations.