Patents by Inventor Joseph J. Ferretti

Joseph J. Ferretti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA encoding hybrid streptokinases with plasminogen fibrin binding domains
    Patent number: 5187098
    Abstract: Compositions and methods of the synthesis of hybrid streptokinase with fibrin binding domains based on gene fusion technology. Recombinant DNA methods have been used to fuse gene segments for streptokinase and for fibrin-binding domains and express the fused gene in prokaryotic microorganisms, and the respective expressed protein is subsequently obtained by biotechnologic fermentation for the purpose of use in clinical medicine.
    Type: Grant
    Filed: May 22, 1992
    Date of Patent: February 16, 1993
    Assignee: Board of Regents of the University of Oklahoma
    Inventors: Horst Malke, Joseph J. Ferretti
  • Streptokinase-coding recombinant vectors
    Patent number: 5066589
    Abstract: A recombinant vector adapted for transformation of a suitable microorganism host to produce and secrete streptokinase. The recombinant vector comprises a plasmid into which a polydeoxyribonucleotide fragment from Streptococcus equisimilis H46A which codes for streptokinase synthesis and secretion has been inserted. The transformant microorganism including this recombinant plasmid vector produces streptokinase suitable for clinical fibrinolytic usage after purification.
    Type: Grant
    Filed: June 27, 1988
    Date of Patent: November 19, 1991
    Assignee: Board of Regents of the University of Okla.
    Inventors: Joseph J. Ferretti, Horst Malke
  • Streptokinase-coding recombinant vectors
    Patent number: 4764469
    Abstract: A recombinant vector adapted for transformation of a suitable bacterial microorganism host to produce and secrete streptokinase. The recombinant vector comprises a plasmid into which a polydeoxyribonucleotide fragment from Streptococcus equisimilis H46A which codes for streptokinase synthesis and secretion has been inserted. The transformant bacterial microorganism including this recombinant plasmid vector produces streptokinase suitable for clinical fibrinolytic usage after purification.
    Type: Grant
    Filed: March 2, 1984
    Date of Patent: August 16, 1988
    Assignee: Board of Regents for the University of Oklahoma
    Inventors: Joseph J. Ferretti, Horst Malke