Patents by Inventor Joseph J. HIGGINS

Joseph J. HIGGINS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MANUFACTURING OF STEM CELLS
    Publication number: 20250011720
    Abstract: Methods of making stem cells, e.g., with an enzyme capable of performing targeted genomic integration, are provided.
    Type: Application
    Filed: November 4, 2022
    Publication date: January 9, 2025
    Inventors: Joseph J. HIGGINS, Ray TABIBIAZAR, Omid F. HARANDI, James B. HEMPHILL
  • TRANSPOSABLE MOBILE ELEMENTS WITH ENHANCED GENOMIC SITE SELECTION
    Publication number: 20250011736
    Abstract: Gene therapy compositions and methods related to transposition are provided.
    Type: Application
    Filed: November 4, 2022
    Publication date: January 9, 2025
    Inventors: Joseph J. HIGGINS, Jesse B. OWENS, Nancy CRAIG
  • MOBILE ELEMENTS AND CHIMERIC CONSTRUCTS THEREOF
    Publication number: 20250002876
    Abstract: Gene therapy compositions and methods related to transposition are provided.
    Type: Application
    Filed: November 4, 2022
    Publication date: January 2, 2025
    Inventors: Joseph J. HIGGINS, Ray TABIBIAZAR, Nancy CRAIG
  • Transposition-based therapies
    Patent number: 11993784
    Abstract: Gene therapy compositions and methods are provided that make use of novel transposases and/or chimeric transposases for targeted transposition.
    Type: Grant
    Filed: March 29, 2023
    Date of Patent: May 28, 2024
    Assignee: Saliogen Therapeutics, Inc.
    Inventors: Joseph J. Higgins, Scott McMillan, Ray Tabibiazar
  • MAMMALIAN MOBILE ELEMENT COMPOSITIONS, SYSTEMS AND THERAPEUTIC APPLICATIONS
    Publication number: 20240002818
    Abstract: Recombinant mammalian helper enzymes for targeted transposition are described. The mammalian helper enzymes and corresponding donor DNAs can be used, e.g., for gene therapy.
    Type: Application
    Filed: November 24, 2021
    Publication date: January 4, 2024
    Inventors: Joseph J. HIGGINS, Ray TABIBIAZAR
  • TRANSPOSITION-BASED THERAPIES
    Publication number: 20230250454
    Abstract: Gene therapy compositions and methods are provided that make use of novel transposases and/or chimeric transposases for targeted transposition.
    Type: Application
    Filed: March 29, 2023
    Publication date: August 10, 2023
    Inventors: Joseph J. HIGGINS, Scott MCMILLAN, Ray TABIBIAZAR
  • TRANSPOSITION-BASED THERAPIES
    Publication number: 20230250453
    Abstract: Gene therapy compositions and methods are provided that make use of novel transposases and/or chimeric transposases for targeted transposition.
    Type: Application
    Filed: November 23, 2022
    Publication date: August 10, 2023
    Inventors: Joseph J. HIGGINS, Scott MCMILLAN, Ray TABIBIAZAR
  • COMPOSITIONS AND METHODS FOR TREATMENT OF INHERITED MACULAR DEGENERATION
    Publication number: 20230193319
    Abstract: Gene therapy compositions and methods are provided for targeting an ATP binding cassette subfamily A member 4 (ABCA4), or a functional fragment thereof, in a patient, thereby treating or mitigating Inherited Macular Degenerations including a Stargardt disease or other diseases that involve retinal degeneration.
    Type: Application
    Filed: April 29, 2021
    Publication date: June 22, 2023
    Inventors: Joseph J. HIGGINS, Scott MCMILLAN, Ray TABIBIAZAR
  • COMPOSITIONS AND METHODS FOR TREATMENT OF FAMILIAL HYPERCHOLESTEROLEMIA AND ELEVATED LOW-DENSITY LIPOPROTEIN CHOLESTEROL
    Publication number: 20230173103
    Abstract: Gene therapy compositions and methods are provided for targeting a very low-density lipoprotein receptor gene (VLDLR) and a low-density lipoprotein receptor gene (LDLR) to lower total cholesterol and/or low-density lipoprotein cholesterol (LDL-C) in a patient, thereby treating or mitigating familial hypercholesterolemia.
    Type: Application
    Filed: April 29, 2021
    Publication date: June 8, 2023
    Inventors: Joseph J. HIGGINS, Scott MCMILLAN, Ray TABIBIAZAR
  • Transposition-based therapies
    Patent number: 11542528
    Abstract: Gene therapy compositions and methods are provided that make use of transposases and/or chimeric transposases for targeted transposition, including engineered enzymes and nucleic acids encoding the same. The provided compositions and methods are suitable of treating, for example, an inherited or acquired disease in a patient, as well as treating and/or mitigating a variety of diseases.
    Type: Grant
    Filed: February 11, 2022
    Date of Patent: January 3, 2023
    Assignee: Saliogen Therapeutics, Inc.
    Inventors: Joseph J. Higgins, Scott McMillan, Ray Tabibiazar
  • TRANSPOSITION-BASED THERAPIES
    Publication number: 20220243227
    Abstract: Gene therapy compositions and methods are provided that make use of novel transposases and/or chimeric transposases for targeted transposition.
    Type: Application
    Filed: February 11, 2022
    Publication date: August 4, 2022
    Inventors: Joseph J. HIGGINS, Scott MCMILLAN, Ray TABIBIAZAR