Patents by Inventor Joseph J. Hoffmann

Joseph J. Hoffmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Triterpene compositions and methods for use thereof
    Patent number: 8324177
    Abstract: The invention provides saponin mixtures and compounds which are isolated from the species Acacia victoriae and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.
    Type: Grant
    Filed: June 14, 2011
    Date of Patent: December 4, 2012
    Assignee: Research Development Foundation
    Inventors: Charles J. Arntzen, Mary E. Blake, Jordan U. Gutterman, Joseph J. Hoffmann, Gamini S. Jayatilake, David T. Bailey
  • TRITERPENE COMPOSITIONS AND METHODS FOR USE THEREOF
    Publication number: 20110294752
    Abstract: The invention provides novel saponin mixtures and compounds which are isolated from the species Acacia victoriae and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.
    Type: Application
    Filed: June 14, 2011
    Publication date: December 1, 2011
    Applicant: RESEARCH DEVELOPMENT FOUNDATION
    Inventors: Charles J. Arntzen, Mary E. Blake, Jordan U. Gutterman, Joseph J. Hoffmann, Gamini S. Jayatilake, David T. Bailey
  • Triterpene compositions and methods for use thereof
    Patent number: 7985435
    Abstract: The invention provides saponin mixtures and compounds which are isolated from the species Acacia victoriae and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: July 26, 2011
    Assignee: Research Development Foundation
    Inventors: Charles J. Arntzen, Mary E. Blake, Jordan U. Gutterman, Joseph J. Hoffmann, Gamini S. Jayatilake, David T. Bailey
  • TRITERPENE COMPOSITIONS AND METHODS FOR USE THEREOF
    Publication number: 20100189824
    Abstract: The invention provides novel saponin mixtures and compounds which are isolated from the species Acacia victoriae and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.
    Type: Application
    Filed: January 15, 2010
    Publication date: July 29, 2010
    Inventors: CHARLES J. ARNTZEN, Mary E. Blake, Jordan U. Gutterman, Joseph J. Hoffmann, Gamini S. Jayatilake, David T. Bailey
  • Triterpene compositions and methods for use thereof
    Patent number: 6444233
    Abstract: The invention provides novel saponin mixtures and compounds which are isolated from the species Acacia victoriae and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoid moieties are attached. The mixtures and compounds have properties related to the regulation of apoptosis and cytotoxicity of cells and exhibit potent anti-tumor effects against a variety of tumor cells.
    Type: Grant
    Filed: May 19, 1999
    Date of Patent: September 3, 2002
    Assignee: Research Development Foundation
    Inventors: Charles J. Arntzen, Mary E. Blake, Jordan U. Gutterman, Joseph J. Hoffmann, Gamini S. Jayatilake, David T. Bailey
  • Antibacterial and antifungal flavanones from Eysenhardtia texana
    Patent number: 6136849
    Abstract: An activity-guided fractionation of a methanol-dichloromethane extract obtained from the aerial parts of Eysenhardtia texana Kunth. (Fabaceae) led to the isolation of two new antibacterial and antifungal flavanones. Their structures were established as 4',5,7-trihydroxy-8-methyl-6-(3-methyl-[2-butenyl])-(2S)-flavanone and 4',5,7-trihydroxy-6-methyl-8-(3-methyl-[2-butenyl])-(2S)-flavanone on the basis of their UV, ID and 2D-NMR spectra. These compounds have potent antibacterial and antifungal activity as measured by bioassay.
    Type: Grant
    Filed: October 6, 1999
    Date of Patent: October 24, 2000
    Inventors: Joseph J. Hoffmann, Gerald A. Wachter, Jordan U. Gutterman