Patents by Inventor Joseph J. Rosa

Joseph J. Rosa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-CD4 antibody homologs useful in prophylaxis and treatment of AIDS, ARC and HIV infection
    Patent number: 5871732
    Abstract: Anti-CD4 antibody homologs, DNA sequences and recombinant DNA molecules encoding them, prophylactic, immunotherapeutic and diagnostic compositions comprising those antibody homologs, and methods for preventing or treating diseases in mammals, including humans, caused by infective agents whose primary targets are CD4.sup.+ lymphocytes. Such diseases include acquired immune deficiency syndrome ("AIDS"), AIDS related complex, and human immunodeficiency virus infection.
    Type: Grant
    Filed: November 27, 1991
    Date of Patent: February 16, 1999
    Assignee: Biogen, Inc.
    Inventors: Linda C. Burkly, Patricia L. Chisholm, David W. Thomas, Margaret D. Rosa, Joseph J. Rosa
  • Modified tissue plasminogen activators
    Patent number: 4753879
    Abstract: Modified human tissue plasminogen activators, the DNA sequences coding on expression for them and methods of making them in hosts transformed with those DNA sequences. The single chain form of these modified human t-PAs, t-PA (Lys 277.fwdarw.X), has a longer half life than the single chain form of native, or recombinant, t-PA, yet, in the two chain form these modified t-PAs have substantially the same affinity for fibrin and substantially the same activity as the two chain form of native, or recombinant, t-PA.
    Type: Grant
    Filed: August 27, 1984
    Date of Patent: June 28, 1988
    Assignee: Biogen N.V.
    Inventors: Joseph J. Rosa, Margaret D. Rosa