Abstract: The present application is directed to recombinant monoclonal antibodies, or antigen fragments thereof that bind a Spike protein of SARS-CoV-2. Methods of using the antibodies to treat or prevent SARS-CoV-2 (COVID-19) are also disclosed.

Abstract: In embodiments, an apparatus for computing may include a receiver; a speaker; circuitry coupled to the receiver and speaker; and a service to be operated by the circuitry to receive an instance of a message via the receiver, and to conditionally affect a provision, through the speaker, an audio notification alert of the receipt of the instance of the message. In embodiments, to conditionally affect the provision may include to bypass or cause to bypass of the provision of the audio notification alert, on determination that another audio notification alert has been or will be provided by another proximally located apparatus for receiving another instance of the same message. Other embodiments may be described and claimed.

Abstract: The present invention relates to engineered outer domain (eOD) immunogens of HIV gp120 and mutants thereof and methods of making and using the same. The present invention also includes fusions of eOD to various protein multimers to enhance immunogenicity. The mutant eODs bind to neutralizing antibody precursors. The mutant eODs can activate germline precursors on the pathway to eliciting a broadly neutralizing antibody (bnAb) response. The invention also relates to immunized knock-in mice expressing germline-reverted heavy chains. Induced antibodies showed characteristics of bnAbs and mutations that favored binding to near-native HIV-1 gp120 constructs. In contrast, native-like immunogens failed to activate precursors. The invention also relates to rational epitope design that can prime rare B cell precursors for affinity maturation to desired targets.

Abstract: The present disclosure relates to anti-HIV Env antibodies and their use in the treatment or prevention of HIV/AIDS.

Abstract: In embodiments, an apparatus for computing may include a receiver; a speaker; circuitry coupled to the receiver and speaker; and a service to be operated by the circuitry to receive an instance of a message via the receiver, and to conditionally affect a provision, through the speaker, an audio notification alert of the receipt of the instance of the message. In embodiments, to conditionally affect the provision may include to bypass or cause to bypass of the provision of the audio notification alert, on determination that another audio notification alert has been or will be provided by another proximally located apparatus for receiving another instance of the same message. Other embodiments may be described and claimed.

Abstract: In embodiments, an apparatus for computing may include a receiver; a speaker; circuitry coupled to the receiver and speaker; and a service to be operated by the circuitry to receive an instance of a message via the receiver, and to conditionally affect a provision, through the speaker, an audio notification alert of the receipt of the instance of the message. In embodiments, to conditionally affect the provision may include to bypass or cause to bypass of the provision of the audio notification alert, on determination that another audio notification alert has been or will be provided by another proximally located apparatus for receiving another instance of the same message. Other embodiments may be described and claimed.

Abstract: In embodiments, an apparatus for computing may include a receiver; a speaker; circuitry coupled to the receiver and speaker; and a service to be operated by the circuitry to receive an instance of a message via the receiver, and to conditionally affect a provision, through the speaker, an audio notification alert of the receipt of the instance of the message. In embodiments, to conditionally affect the provision may include to bypass or cause to bypass of the provision of the audio notification alert, on determination that another audio notification alert has been or will be provided by another proximally located apparatus for receiving another instance of the same message. Other embodiments may be described and claimed.

Abstract: The present invention relates to engineered outer domain (eOD) immunogens of HIV gp120 and mutants thereof and methods of making and using the same. The present invention also includes fusions of eOD to various protein multimers to enhance immunogenicity. The mutant eODs bind to neutralizing antibody precursors. The mutant eODs can activate germline precursors on the pathway to eliciting a broadly neutralizing antibody (bnAb) response. The invention also relates to immunized knock-in mice expressing germline-reverted heavy chains. Induced antibodies showed characteristics of bnAbs and mutations that favored binding to near-native HIV-1 gp120 constructs. In contrast, native-like immunogens failed to activate precursors. The invention also relates to rational epitope design that can prime rare B cell precursors for affinity maturation to desired targets.