Patents by Inventor Joseph Joel Pollak
Joseph Joel Pollak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190145963Abstract: Apparatus and methods are described for use with a blood sample (48, 50), including measuring hemoglobin concentration within at least a portion (48) of the blood sample, by performing a first measurement on the blood sample. Mean corpuscular hemoglobin in the blood sample (48, 50) is measured, by performing a second measurement on the blood sample (48, 50). A parameter of the blood sample is determined, based on a relationship between the concentration of hemoglobin and the mean corpuscular hemoglobin. Other applications are also described.Type: ApplicationFiled: May 11, 2017Publication date: May 16, 2019Applicant: S.D. Sight Diagnostics Ltd.Inventors: Amir ZAIT, Arnon HOURI YAFIN, Dan GLUCK, Sharon PECKER, Yochay Shlomo ESHEL, Sarah LEVY SCHREIER, Joseph Joel POLLAK
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Publication number: 20190130567Abstract: Apparatus and methods are described for use with a cell sample. For each of one or more imaging fields of the cell sample, a depth scan of the cell sample is performed using a microscope. One of the depth levels is identified as being an optimum focal plane for imaging one or more entities within the sample using the microscope, at least partially in response to detecting that the depth level corresponds to a drop in image contrast relative to image contrast at other depth levels. Based upon the depth level identified as being the optimum focal plane for each of the one or more imaging fields of the cell sample, a scanning depth interval over which to perform a depth scan of the cell sample at a further imaging field is defined. Other applications are also described.Type: ApplicationFiled: December 26, 2018Publication date: May 2, 2019Applicant: S.D. SIGHT DIAGNOSTICS LTD.Inventors: Yuval Greenfield, Yonatan Bilu, Joseph Joel Pollak, Noam Yorav-Raphael
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Publication number: 20190087953Abstract: A digital microscopy method, comprising: obtaining data representative of a series of images of at least a portion of a cell sample, the images being captured by performing a depth scan using a digital microscope, the series of images being associated with a series of depth levels of the cell sample, wherein the portion encompasses a mapping field, and the mapping field comprises a plurality of focus analysis regions; and calculating, using the images, a focus configuration for at least two of the focus analysis regions within the mapping field, giving rise to data indicative of focus variations within the mapping field.Type: ApplicationFiled: August 27, 2015Publication date: March 21, 2019Applicant: S.D. Sight Diagnostics LtdInventors: Noam YORAV-RAPHAEL, Uri WOLFOVITZ, Joseph Joel POLLAK
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Patent number: 10176565Abstract: The present disclosure provides a method of determining a reference depth level within a cell sample. The method comprises obtaining data representative of a series of images captured by performing a depth scan of the cell sample using a digital microscope, the series of images being associated with a series of depth levels of the cell sample; processing said data for detecting at least one depth level corresponding to a drop in image contrast; and identifying the detected depth level as the reference depth level.Type: GrantFiled: May 23, 2014Date of Patent: January 8, 2019Assignee: S.D. SIGHT DIAGNOSTICS LTD.Inventors: Yuval Greenfield, Yonatan Bilu, Joseph Joel Pollak, Noam Yorav-Raphael
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Publication number: 20190002950Abstract: Apparatus and methods are described including introducing a cell suspension comprising red blood cells into a carrier that is a closed cavity that includes a base surface, via an inlet defined by the carrier. The cells in the cell suspension are allowed to settle on the base surface of the carrier to form a monolayer of cells on the base surface of the carrier. At least one microscope image of at least a portion of the monolayer of cells is acquired. Other applications are also described.Type: ApplicationFiled: August 21, 2018Publication date: January 3, 2019Applicant: S.D. SIGHT DIAGNOSTICS LTD.Inventors: Joseph Joel POLLAK, Arnon HOURI YAFIN, Seth J. SALPETER
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Patent number: 10093957Abstract: Provided is a method for imaging a blood sample and a kit and system for executing the method. The method includes introducing a cell suspension including red blood cells onto a base surface of a carrier having a vertical height (H) being greater than or equal to a vertical depth (h) of the cell suspension when on the base carrier, the cell suspension including a cell concentration (C) being determined by a defined function; allowing the cells in the cell suspension to settle on the base surface of the carrier to form a monolayer of cells thereon; and acquiring at least one microscope image of at least a portion of the monolayer of cells; wherein the at least one microscope image is obtained by a microscope set to Depth Of Field that is not more than 20% of the vertical height of the cell suspension settled on the base surface.Type: GrantFiled: March 29, 2016Date of Patent: October 9, 2018Assignee: S.D. SIGHT DIAGNOSTICS LTD.Inventors: Joseph Joel Pollak, Arnon Houri Yafin, Seth J. Salpeter
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Publication number: 20180246313Abstract: Apparatus and methods are described including a microscope system (11) configured to acquire one or more micro scope images of a bodily sample, an output device (34), and at least one computer processor (28). The computer processor identifies, in the one or more images, at least one element as being a pathogen candidate, and extracts, from the one or more images, at least one candidate-informative feature associated with the pathogen candidate. The compute processor extracts, from the one or more images, at least one sample-informative feature that is indicative of contextual information related to the bodily sample. The computer processor classifies a likelihood of the bodily sample being infected with a pathogenic infection, by processing the candidate-informative feature in combination with the sample-informative feature, and generates an output upon the output device, in response thereto. Other applications are also described.Type: ApplicationFiled: September 15, 2016Publication date: August 30, 2018Applicant: S.D. SIGHT DIAGNOSTICS LTDInventors: Yochay Shlomo ESHEL, Natalie LEZMY, Dan GLUCK, Arnon HOURI YAFIN, Joseph Joel POLLAK
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Patent number: 9522396Abstract: The invention discloses an apparatus and method for automatic detection of pathogens within a sample. The apparatus and method are especially useful for high-throughput and/or low-cost detection of parasites with minimal need for trained personnel. The invention entails automated microscopic data acquisition, and performing image processing of images captured from a sample using classification algorithms. Visual classification features of structures are extracted from the image and compared to visual classification features associated with known pathogens. A determination is reached whether a pathogen is present in the sample; and if present, the pathogen may be identified to a pathogen species. Diagnosis is rapid and does not require medically trained personnel.Type: GrantFiled: December 28, 2011Date of Patent: December 20, 2016Assignee: S.D. Sight Diagnostics Ltd.Inventors: Ido Bachelet, Joseph Joel Pollak, Daniel Levner, Yonatan Bilu, Noam Yorav-Raphael
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Publication number: 20160279633Abstract: Apparatus and methods are described for use with a digital camera that is configured to acquire images of a bodily sample. Two or more stains are configured to stain the bodily sample. A computer processor drives the digital camera to acquire, for each of a plurality of imaging fields of the bodily sample, two or more digital images, at least one of the images being acquired under brightfield lighting conditions, and at least one of the images being acquired under fluorescent lighting conditions. The computer processor performs image processing on the digital images, by extracting visual classification features from the digital images and analyzing the extracted visual classification features. The computer processor outputs a result of the image processing that includes an indication of one or more entities that are contained within the sample. Other applications are also described.Type: ApplicationFiled: June 6, 2016Publication date: September 29, 2016Applicant: S.D. Sight Diagnostics LtdInventors: Ido Bachelet, Joseph Joel Pollak, Daniel Levner, Yonatan Bilu, Noam Yorav-Raphael
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Publication number: 20160246046Abstract: Methods, systems and computer program products relating to digital microscopy are disclosed. A digital microscopy method may comprise capturing a plurality of overlapping images of a sample, wherein the capturing of at least one of the plurality of images is performed while the sample and a focal plane are in relative motion along an optical axis at a speed greater than zero; and processing the plurality of images using a reference criterion to determine a reference relative arrangement of the focal plane and the sample along the optical axis.Type: ApplicationFiled: August 26, 2014Publication date: August 25, 2016Applicant: S.D. Sight Diagnostics Ltd.Inventors: Noam YORAV RAPHAEL, Yuval GREENFIELD, Joseph Joel POLLAK, Yonatan BILU
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Publication number: 20160208306Abstract: Provided is a method for imaging a blood sample and a kit and system for executing the method. The method includes introducing a cell suspension including red blood cells onto a base surface of a carrier having a vertical height (H) being greater than or equal to a vertical depth (h) of the cell suspension when on the base carrier, the cell suspension including a cell concentration (C) being determined by a defined function; allowing the cells in the cell suspension to settle on the base surface of the carrier to form a monolayer of cells thereon; and acquiring at least one microscope image of at least a portion of the monolayer of cells; wherein the at least one microscope image is obtained by a microscope set to Depth Of Field that is not more than 20% of the vertical height of the cell suspension settled on the base surface.Type: ApplicationFiled: March 29, 2016Publication date: July 21, 2016Applicant: S.D. SIGHT DIAGNOSTICS LTD.Inventors: Joseph Joel POLLAK, Arnon HOURI YAFIN, Seth J. SALPETER
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Patent number: 9329129Abstract: Provided is a method for imaging a blood sample and a kit and system for executing the method. The method includes introducing a cell suspension including red blood cells onto a base surface of a carrier having a vertical height (H) being greater than or equal to a vertical depth (h) of the cell suspension when on the base carrier, the cell suspension including a cell concentration (C) being determined by a defined function; allowing the cells in the cell suspension to settle on the base surface of the carrier to form a monolayer of cells thereon; and acquiring at least one microscope image of at least a portion of the monolayer of cells; wherein the at least one microscope image is obtained by a microscope set to Depth Of Field that is not more than 20% of the vertical height of the cell suspension settled on the base surface.Type: GrantFiled: June 30, 2014Date of Patent: May 3, 2016Assignee: S.D. SIGHT DIAGNOSTICS LTD.Inventors: Joseph Joel Pollak, Arnon Houri Yafin, Seth J. Salpeter
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Publication number: 20150316477Abstract: Provided is a method for imaging a blood sample and a kit and system for executing the method. The method includes introducing a cell suspension including red blood cells onto a base surface of a carrier having a vertical height (H) being greater than or equal to a vertical depth (h) of the cell suspension when on the base carrier, the cell suspension including a cell concentration (C) being determined by a defined function; allowing the cells in the cell suspension to settle on the base surface of the carrier to form a monolayer of cells thereon; and acquiring at least one microscope image of at least a portion of the monolayer of cells; wherein the at least one microscope image is obtained by a microscope set to Depth Of Field that is not more than 20% of the vertical height of the cell suspension settled on the base surface.Type: ApplicationFiled: June 30, 2014Publication date: November 5, 2015Applicant: S.D. SIGHT DIAGNOSTICS LTD.Inventors: Joseph Joel Pollak, Arnon Houri Yafin, Seth J. Salpeter
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Publication number: 20150037806Abstract: Disclosed herein, inter alia, is method, kit and systems for detecting a pathogen infection in a bodily sample, the method comprising (i) staining said bodily sample with two or more dyes, comprising at least one dye predominantly staining DNA to thereby provide differential staining between DNA and at least one other cellular component being different from DNA; (ii) identifying at least a first stained area comprising the DNA, if exists in the sample, and at least one other stained area comprising the other cellular component; (iii) extracting structural features for the first stained area and the at least one other stained area, said structural features comprise at least one of (i) size of at least one of the first stained area and one other stained area and (ii) location of said first stained area and said at least one other stained area one with respect to the other; and (iv) determining the presence of a suspected pathogen in the bodily sample if a first stained area was identified and said structural feType: ApplicationFiled: December 27, 2012Publication date: February 5, 2015Applicant: SIGHT DIAGNOSTICS LTD.Inventors: Joseph Joel Pollak, Daniel Levner, Yonatan Bilu, Arnon Yafin, Noam Yorav-Raphael, Yuval Greenfield
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Publication number: 20140347459Abstract: The present disclosure provides a method of determining a reference depth level within a cell sample. The method comprises obtaining data representative of a series of images captured by performing a depth scan of the cell sample using a digital microscope, the series of images being associated with a series of depth levels of the cell sample; processing said data for detecting at least one depth level corresponding to a drop in image contrast; and identifying the detected depth level as the reference depth level.Type: ApplicationFiled: May 23, 2014Publication date: November 27, 2014Applicant: PARASIGHT LTD.Inventors: Yuval Greenfield, Yonatan Bilu, Joseph Joel Pollak, Noam Yorav-Raphael
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Publication number: 20120169863Abstract: The invention discloses an apparatus and method for automatic detection of pathogens within a sample. The apparatus and method are especially useful for high-throughput and/or low-cost detection of parasites with minimal need for trained personnel. The invention entails automated microscopic data acquisition, and performing image processing of images captured from a sample using classification algorithms. Visual classification features of structures are extracted from the image and compared to visual classification features associated with known pathogens. A determination is reached whether a pathogen is present in the sample; and if present, the pathogen may be identified to a pathogen species. Diagnosis is rapid and does not require medically trained personnel.Type: ApplicationFiled: December 28, 2011Publication date: July 5, 2012Inventors: Ido Bachelet, Joseph Joel Pollak, Daniel Levner, Yonatan Bilu, Noam Yorav-Raphael