Patents by Inventor Joseph John Topczewski

Joseph John Topczewski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted phenethylamine derivatives
    Patent number: 10941153
    Abstract: Embodiments of the present disclosure describe substituted phenethylamine derivatives, compositions comprising the substituted phenethylamine derivatives, methods of making the substituted phenethylamine derivatives, and methods of using the phenethylamine derivatives, and the like. Exemplary compounds of the present disclosure include compounds of the formula (I) and (II): wherein X, Ra, Rb, Rc, R1, R2, R3, and R4 are defined elsewhere.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: March 9, 2021
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Joseph John Topczewski, Matthew Ryan Porter
  • SUBSTITUTED PHENETHYLAMINE DERIVATIVES
    Publication number: 20190367527
    Abstract: Embodiments of the present disclosure describe substituted phenethylamine derivatives, compositions comprising the substituted phenethylamine derivatives, methods of making the substituted phenethylamine derivatives, and methods of using the phenethylamine derivatives, and the like. Exemplary compounds of the present disclosure include compounds of the formula (I) and (II): wherein X, Ra, Rb, Rc, R1, R2, R3, and R4 are defined elsewhere.
    Type: Application
    Filed: May 31, 2019
    Publication date: December 5, 2019
    Inventors: Joseph John Topczewski, Matthew Ryan Porter
  • Compounds and methods to treat organophosphorus poisoning
    Patent number: 9884052
    Abstract: Organophosphate (OP) nerve agents and pesticides are potent inhibitors of acetylcholinesterase (AChE). Though oxime nucleophiles can reactivate an AChE-phosphyl adduct, the adduct can undergo a reaction called aging, leading to an aged-AChE adduct. The invention provides compounds and methods that can be used to reactivate an aged-AChE adduct. Such compounds and methods are useful to counteract organophosphorus poisoning.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: February 6, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Daniel M. Quinn, Joseph John Topczewski
  • COMPOUNDS AND METHODS TO TREAT ORGANOPHOSPHORUS POISONING
    Publication number: 20160151342
    Abstract: Organophosphate (OP) nerve agents and pesticides are potent inhibitors of acetylcholinesterase (AChE). Though oxime nucleophiles can reactivate an AChE-phosphyl adduct, the adduct can undergo a reaction called aging, leading to an aged-AChE adduct. The invention provides compounds and methods that can be used to reactivate an aged-AChE adduct. Such compounds and methods are useful to counteract organophosphorus poisoning.
    Type: Application
    Filed: November 24, 2015
    Publication date: June 2, 2016
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Daniel M. Quinn, Joseph John Topczewski
  • Compounds and methods to treat organophosphorus poisoning
    Patent number: 9249100
    Abstract: Organophosphate (OP) nerve agents and pesticides are potent inhibitors of acetylcholinesterase (AChE). Though oxime nucleophiles can reactivate an AChE-phosphyl adduct, the adduct can undergo a reaction called aging, leading to an aged-AChE adduct. The invention provides compounds and methods that can be used to reactivate an aged-AChE adduct. Such compounds and methods are useful to counteract organophosphorus poisoning.
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: February 2, 2016
    Assignee: University of Iowa Research Foundation
    Inventors: Daniel M. Quinn, Joseph John Topczewski
  • COMPOUNDS AND METHODS TO TREAT ORGANOPHOSPHORUS POISONING
    Publication number: 20140323473
    Abstract: Organophosphate (OP) nerve agents and pesticides are potent inhibitors of acetylcholinesterase (AChE). Though oxime nucleophiles can reactivate an AChE-phosphyl adduct, the adduct can undergo a reaction called aging, leading to an aged-AChE adduct. The invention provides compounds and methods that can be used to reactivate an aged-AChE adduct. Such compounds and methods are useful to counteract organophosphorus poisoning.
    Type: Application
    Filed: January 24, 2014
    Publication date: October 30, 2014
    Applicant: University of Iowa Research Foundation
    Inventors: Daniel Quinn, Joseph John Topczewski