Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: An approach for directing a call to a matching service of a call destination is described. A call matching manager determines that a call is to be redirected from a first voice response unit based on service data about a service and caller data about a caller. The call matching manager also queries, during the call, one or more databases corresponding to a plurality of other services to identify a matching service based on the caller data. Still further, the call matching manager initiates transfer of the call for processing by a second voice response unit via out-of-band telephony signaling using a generated reference value.

Abstract: An approach for directing a call to a matching service of a call destination is described. A call matching manager determines that a call is to be redirected from a first voice response unit based on service data about a service and caller data about a caller. The call matching manager also queries, during the call, one or more databases corresponding to a plurality of other services to identify a matching service based on the caller data. Still further, the call matching manager initiates transfer of the call for processing by a second voice response unit via out-of-band telephony signaling using a generated reference value.

Abstract: A universal adjustable insole with an arch support said insole and arch support is positioned under a foot and is sized and shaped to be removable placed within a foot support enclosure worn by a user. The insole comprises a top layer, a lower layer, a pocket between top and bottom layers corresponding to the arch-of-the-foot portion of the top pad layer for the arch support and one or several inserts free disposed inside said pocket.

Abstract: Optical signals are passed in an optical medium using an approach that facilitates the mitigation of interference. According to an example embodiment, a filtering-type approach is used with an optical signal conveyed in an optical fiber, such as a multimode fiber (MMF) or a multimode waveguide. Adaptive spatial domain signal processing, responsive to a feedback signal indicative of data conveyed in the multimode waveguide, is used to mitigate interference in optical signals conveyed in the multimode waveguide.

Abstract: A pen-based computer text input system capable of interpreting a special pre-defined set of single stroke glyphs. Each input stroke is identified with one of three categories: (1) pre-character modifier strokes, (2) character or symbol strokes, or (3) post-character modifier strokes. Pre-character modifier strokes precede character strokes and inform the present recognition system that a subsequently entered character stroke is to be modified by the pre-character modifier stroke in a pre-defined manner. Character strokes cause a character or symbol to be displayed on the display device the moment it is input on the writing tablet, interpreted in accordance with any pre-character modifier stroke. A post-character modifier stroke causes the recognition system to modify, in a pre-defined manner, a character or symbol which was previously entered and displayed. An important advantage of the present invention is its ability to provide immediate recognition of multiple stroke characters without using boxed input.

Abstract: A pen-based computer text input system capable of interpreting a special pre-defined set of single stroke glyphs. Each input stroke is identified with one of three categories: (1) pre-character modifier strokes, (2) character or symbol strokes, or (3) post-character modifier strokes. Pre-character modifier strokes precede character strokes and inform the present recognition system that a subsequently entered character stroke is to be modified by the pre-character modifier stroke in a pre-defined manner. Character strokes cause a character or symbol to be displayed on the display device the moment it is input on the writing tablet, interpreted in accordance with any pre-character modifier stroke. A post-character modifier stroke causes the recognition system to modify, in a pre-defined manner, a character or symbol which was previously entered and displayed. An important advantage of the present invention is its ability to provide immediate recognition of multiple stroke characters without using boxed input.

Abstract: A pen-based computer text input system capable of interpreting a special pre-defined set of single stroke glyphs. Each input stroke is identified with one of three categories: (1) pre-character modifier strokes, (2) character or symbol strokes, or (3) post-character modifier strokes. Pre-character modifier strokes precede character strokes and inform the present recognition system that a subsequently entered character stroke is to be modified by the pre-character modifier stroke in a pre-defined manner. Character strokes cause a character or symbol to be displayed on the display device the moment it is input on the writing tablet, interpreted in accordance with any pre-character modifier stroke. A post-character modifier stroke causes the recognition system to modify, in a pre-defined manner, a character or symbol which was previously entered and displayed. An important advantage of the present invention is its ability to provide immediate recognition of multiple stroke characters without using boxed input.