Patents by Inventor Joseph Kareh
Joseph Kareh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11351477Abstract: Techniques are described for accelerating thermal equilibrium in a chromatographic column. An apparatus comprises a chromatography column, and a plurality of temperature control units in thermal contact with the chromatography column. A method of performing liquid chromatography comprises setting an inlet of a chromatography column to a first temperature using a first temperature control unit in thermal contact with said inlet, setting an outlet of the chromatography column to a second temperature using a second temperature control unit in thermal contact with the outlet, wherein the first temperature is less than the second temperature; and injecting a sample into a liquid stream that flows through the chromatography column after the inlet is set at the first temperature and the outlet is at the second temperature.Type: GrantFiled: October 8, 2019Date of Patent: June 7, 2022Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Edouard S. P. Bouvier, Joseph Kareh
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Publication number: 20200139264Abstract: Techniques are described for accelerating thermal equilibrium in a chromatographic column. An apparatus comprises a chromatography column, and a plurality of temperature control units in thermal contact with the chromatography column. A method of performing liquid chromatography comprises setting an inlet of a chromatography column to a first temperature using a first temperature control unit in thermal contact with said inlet, setting an outlet of the chromatography column to a second temperature using a second temperature control unit in thermal contact with the outlet, wherein the first temperature is less than the second temperature; and injecting a sample into a liquid stream that flows through the chromatography column after the inlet is set at the first temperature and the outlet is at the second temperature.Type: ApplicationFiled: October 8, 2019Publication date: May 7, 2020Inventors: Edouard S.P. Bouvier, Joseph Kareh
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Patent number: 10478750Abstract: Techniques are described for accelerating thermal equilibrium in a chromatographic column. An apparatus comprises a chromatography column, and a plurality of temperature control units in thermal contact with the chromatography column. A method of performing liquid chromatography comprises setting an inlet of a chromatography column to a first temperature using a first temperature control unit in thermal contact with said inlet, setting an outlet of the chromatography column to a second temperature using a second temperature control unit in thermal contact with the outlet, wherein the first temperature is less than the second temperature; and injecting a sample into a liquid stream that flows through the chromatography column after the inlet is set at the first temperature and the outlet is at the second temperature.Type: GrantFiled: June 26, 2013Date of Patent: November 19, 2019Assignee: Waters Technologies CorporationInventors: Edouard S. P. Bouvier, Joseph Kareh
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Publication number: 20160310869Abstract: Embodiments of the present invention are directed to apparatus and methods for performing separations of compounds held in a solution. Embodiments of the present invention allow detectors to operate at constant reproducible temperatures that are lower than the temperature of fluids exiting separation devices. An apparatus of the present invention has pump means, fluid conveying means, sample injection means, separation means and heat dissipation means. The heat dissipation means is in fluid communication with the separation means for receiving the fluid and removing thermal energy.Type: ApplicationFiled: June 29, 2016Publication date: October 27, 2016Inventors: Joseph A. Kareh, David Alden Piper
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Publication number: 20150157959Abstract: Techniques are described for accelerating thermal equilibrium in a chromatographic column. An apparatus comprises a chromatography column, and a plurality of temperature control units in thermal contact with the chromatography column. A method of performing liquid chromatography comprises setting an inlet of a chromatography column to a first temperature using a first temperature control unit in thermal contact with said inlet, setting an outlet of the chromatography column to a second temperature using a second temperature control unit in thermal contact with the outlet, wherein the first temperature is less than the second temperature; and injecting a sample into a liquid stream that flows through the chromatography column after the inlet is set at the first temperature and the outlet is at the second temperature.Type: ApplicationFiled: June 26, 2013Publication date: June 11, 2015Inventors: Edouard S.P. Bouvier, Joseph Kareh
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Patent number: 9027635Abstract: A device for withdrawing heat energy from air. The device includes a layer of a substantially hydrophobic coating on a heat exchange surface. The coating has a lower surface tension than water, to repel water and prevent the formation of water condensation on the surface. For example, the coating can be a fluoropolymer such as 1,1,2,3,3,3 hexafluoropropene.Type: GrantFiled: August 24, 2005Date of Patent: May 12, 2015Assignee: Waters Technologies CorporationInventors: Douglas Wittmer, Joseph Kareh, Theodore D. Ciolkosz, Joseph A. Jarrell
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Patent number: 8956534Abstract: Disclosed is a chromatographic system and method which includes a passive pre-heater assembly. In the inventive system and method a fluid mixture is supplied from an injector to the pre-heater assembly and then to a chromatographic column having an active heating source. The pre-heater assembly includes a convoluted tube with first and second ends and a fluid passage extending centrally therebetween, first and second end fittings attached respectively to the first and second ends of the convoluted tube, and a thermally conductive film attached to an outer surface of the convoluted tube. The first end fitting is adapted for fluidly connecting the first end of the convoluted tube to the injector and the second end fitting is adapted for fluidly connecting the second end of the convoluted tube to the chromatographic column.Type: GrantFiled: August 5, 2005Date of Patent: February 17, 2015Assignee: Waters Technologies CorporationInventors: Edward J. Ognibene, Joseph A. Kareh, Uwe D. Neue, Theodore D. Ciolkosz, Richard W. Andrews, Marc Lemelin, Peyton C. Beals
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Publication number: 20130118706Abstract: An inspection device and method, the device comprising a thermoelectric module (3) with first and second conducting parts (31, 32) and a control unit (4) electrically connected to the thermoelectric module for selectively applying an electric potential to the thermoelectric module to create a temperature difference between the first and second conducting parts. The control unit comprises measuring means configured to measure transiently, in use, a voltage potential across the thermoelectric module. The control unit includes memory means for recording a measured voltage profile and further comprises comparing means (41) for comparing the measured profile with a predetermined voltage profile stored in the memory means.Type: ApplicationFiled: April 6, 2011Publication date: May 16, 2013Applicant: WATERS TECHNOLOGIES CORPORATIONInventors: Joseph A. Kareh, Theodore D. Ciolkosz, Ziad El-Massih
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Publication number: 20100278695Abstract: The invention provides improved separation media for use in chromatography and electrophoresis, or for the selective absorption of certain components of a sample mixture, especially in a preliminary stage of an analysis. Improved media according to the invention comprises first particles capable or retaining one or more of the components of a sample mixture and second particles selected to have a higher thermal conductivity than the first particles, so that the thermal conductivity of the media is higher than that of media comprising the first particles alone. The media may be incorporated in packed or capillary columns for chromatography (especially nanoflow HPLC) or for capillary electrophoresis, or may be coated on a substrate. Particular embodiments of the media may comprise mixtures of first particles comprising siliceous polymers, second particles of gold, diamond or graphite. Chromatographic columns and apparatus incorporating them are also disclosed.Type: ApplicationFiled: May 6, 2008Publication date: November 4, 2010Applicant: WATERS TECHNOLOGIES CORPORATIONInventors: David Alden Piper, Joseph A. Kareh
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Publication number: 20090211978Abstract: Disclosed is a chromatographic system and method which includes a passive pre-heater assembly. In the inventive system and method a fluid mixture is supplied from an injector to the pre-heater assembly and then to a chromatographic column having an active heating source. The pre-heater assembly includes a convoluted tube with first and second ends and a fluid passage extending centrally therebetween, first and second end fittings attached respectively to the first and second ends of the convoluted tube, and a thermally conductive film attached to an outer surface of the convoluted tube. The first end fitting is adapted for fluidly connecting the first end of the convoluted tube to the injector and the second end fitting is adapted for fluidly connecting the second end of the convoluted tube to the chromatographic column.Type: ApplicationFiled: August 5, 2005Publication date: August 27, 2009Applicant: Waters Investments LimitedInventors: Edward J. Ognibene, Joseph A. Kareh, Uwe D. Neue, Theodore D. Ciolkosz, Richard W. Andrews, Marc Lemelin, Peyton C. Beals
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Publication number: 20090159751Abstract: Embodiments of the present invention feature heat exchange surfaces having a layer or coating having a lower surface tension than water, to repel water and prevent the formation of condensate on said surface.Type: ApplicationFiled: August 24, 2005Publication date: June 25, 2009Applicant: WATERS INVESTMENTS LIMITEDInventors: Douglas P. Wittmer, Joseph Kareh, Theodore D. Ciolkosz, Joseph A. Jarrell
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Publication number: 20080314812Abstract: Embodiments of the present invention are directed to apparatus and methods for performing separations of compounds held in a solution. Embodiments of the present invention allow detectors to operate at constant reproducible temperatures that are lower than the temperature of fluids exiting separation devices. An apparatus of the present invention has pump means, fluid conveying means, sample injection means, separation means and heat dissipation means. The heat dissipation means is in fluid communication with the separation means for receiving the fluid and removing thermal energy.Type: ApplicationFiled: January 16, 2007Publication date: December 25, 2008Applicant: WATERS INVESTMENTS LIMITEDInventors: Joseph A. Kareh, David Alden Piper