Abstract: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.

Abstract: Systems and methods for agentless remediation and recovery. In an illustrative, non-limiting embodiment, an Information Handling System (IHS) may include a Central Processing Unit (CPU); a Basic Input/Output System (BIOS) coupled to the CPU; a logic controller coupled to the CPU; and a memory coupled to the logic controller, the memory having program instructions stored thereon that, upon execution by the logic controller, cause the IHS to: during a first stage, check an operational state of a plurality of hardware components within the IHS in the absence of any involvement by the CPU or the BIOS; and during a second stage following the first stage, identify a failed hardware component amongst the plurality of hardware components in the absence of any involvement by the CPU or the BIOS.

Abstract: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I, or pharmaceutically acceptable salts thereof, Formula I or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.

Abstract: A method and system comprising a processor executing code instructions of a security filewall validation system for inspecting primitive file system operations to detect abnormal file types, abnormal file operation, or abnormal intended result files in violation of a security filewall rule set, a memory for storing the security filewall rule set describing permitted access to file types, file-paths, mounting points, data volume access rules, or data operations relating to the primitive file system operations where the security filewall validation system intercepts an attempted primitive file system operation and the security filewall validation system compares the attempted primitive file system operation including associated arguments indicating file, file location, and intended result to the security filewall rule set.

Abstract: The present invention relates to novel Silane-Containing Heterocyclic Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, A?, B, B?, R1 R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one Silane-Containing Heterocyclic Compound, and methods of using the Silane-Containing Heterocyclic Compounds for treating or preventing HCV infection in a patient.

Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

Abstract: In one or more embodiments, one or more systems, methods, and/or processes may create a task configured to configure an out-of-band system of an unconfigured information handling system and discover configured information handling systems and unconfigured information handling systems that include respective out-of-band systems operable to perform the task independently of respective main processors. The one or more systems, methods, and/or processes may provide, via a network, the task to the respective out-of-band systems of the unconfigured information handling systems. In one or more embodiments, the one or more systems, methods, and/or processes may create another task configured to unconfigure the out-of-band system that was configured via the task configured to configure the out-of-band systems and may provide, via the network, the other task to at least one information handling system that was provided the task configured to configure the out-of-band system.

Abstract: Systems and methods for agentless remediation and recovery. In an illustrative, non-limiting embodiment, an Information Handling System (IHS) may include a Central Processing Unit (CPU); a Basic Input/Output System (BIOS) coupled to the CPU; a logic controller coupled to the CPU; and a memory coupled to the logic controller, the memory having program instructions stored thereon that, upon execution by the logic controller, cause the IHS to: during a first stage, check an operational state of a plurality of hardware components within the IHS in the absence of any involvement by the CPU or the BIOS; and during a second stage following the first stage, identify a failed hardware component amongst the plurality of hardware components in the absence of any involvement by the CPU or the BIOS.

Abstract: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.

Abstract: In one or more embodiments, one or more systems, methods, and/or processes may receive, independently of a processor of the information handling system (IHS), first credential management information and may modify, independently of the processor and based on the first credential management information, credential information stored via a secure object store of the IHS. For example, modifying the credential information may include modifying the credential information such that the IHS denies access to at least a portion of the IHS based on the credential information. In one instance, denying access to at least the portion of the IHS may include disabling at least one of password, biometric information associated with a user, and an encryption key. In another instance, denying access to at least the portion of the IHS may include remapping, independently of the processor, at least one human interface device.

Abstract: In one or more embodiments, one or more systems, method, and/or processes may receive processor instructions via an out-of-band system of an information handling system (IHS) and store the processor instructions via a storage device. For example, the processor instructions may be stored via a hidden partition of the storage device. While the out-of-band system receives the processor instructions, one or more of the IHS and a processor of the IHS may be in a low-power state. For example, the processor may not execute any instructions in the low-power state. While the out-of-band system receives the processor instructions, one or more of the IHS, an operating system of the IHS, and IHS firmware of the IHS may be impaired or inoperable, and the processor instructions may provide one or more remedies and/or repairs. In one or more embodiments, the IHS may be booted after the processor instructions are stored.

Abstract: Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (I).

Abstract: In one or more embodiments, one or more systems, method, and/or processes may receive an event from an operating system and provide the event to a management controller configured to perform out-of-band tasks. The management controller may provide information based on the event to at least one subscriber. In one example, the information may include a status of an information handling system (e.g., an impairment, a hardware failure, a progress of an update, etc.). In another example, the management controller may provide information utilizing a protocol that provides a measure of reliability. For instance, the protocol may include a transmission control protocol. In one or more embodiments, the protocol may include one or more of a hypertext transfer protocol (HTTP) and a HTTP secure (HTTPS).

Abstract: Systems and methods for agentless remediation and recovery. In an illustrative, non-limiting embodiment, an Information Handling System (IHS) may include a Central Processing Unit (CPU); a Basic Input/Output System (BIOS) coupled to the CPU; a logic controller coupled to the CPU; and a memory coupled to the logic controller, the memory having program instructions stored thereon that, upon execution by the logic controller, cause the IHS to: during a first stage, check an operational state of a plurality of hardware components within the IHS in the absence of any involvement by the CPU or the BIOS; and during a second stage following the first stage, identify a failed hardware component amongst the plurality of hardware components in the absence of any involvement by the CPU or the BIOS.

Abstract: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.

Abstract: Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (I).

Abstract: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, Formula (I) or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.

Abstract: An information handling system includes a primary integrated display device housing and a second integrated display device housing attached via a hinge and a processor to determine a first relative orientation of the primary integrated display device housing to the second integrated display device housing from a plurality of orientation sensors. The processor further determines a working software application context by detecting at least a first software application running on the information handling system wherein the working software application context further includes an operating state rank of the first software application relative to other software applications.

Abstract: The present invention provides a compound of Formula (I) or the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are ERK2 inhibitors. The invention also provides a method of inhibiting ERK2 in a patient in need of such treatment comprising administering to said patient an effective amount of at least one compound of Formula (I). The invention also provides a method for treating cancer in a patient in need of such treatment, said method comprising administering to said patient an effective amount of at least one compound of Formula (I).

Abstract: Systems and methods for protected local backup. In an illustrative, non-limiting embodiment, an Information Handling System (IHS) may include one or more processors and a memory coupled to the one or more processors, the memory including program instructions stored thereon that, upon execution by the one or more processors, cause the IHS to: receive, via a file system filter driver, a request targeting a file system within a storage device, wherein the file system filter driver is owned by a backup application; and reject the request, via the file system filter driver, in response to the request having been issued by an application other than the backup application.