Patents by Inventor Joseph L. Herman
Joseph L. Herman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11333639Abstract: Systems, apparatuses, kits, and methods for purification and analysis of analytes having a broad range of hydrophobicities by liquid chromatography-mass spectrometry (LC-MS). Using one set of liquid chromatography columns, one set of mobile phase buffers, and, optionally, a single ionization method (e.g., electrospray ionization), a wide range of analytes can be purified and analyzed on a liquid chromatography-mass spectrometry (LC-MS) system. LC-MS purification and analysis of analytes having a broad range of partition coefficients is accomplished by selecting LC run parameters and MS system parameters that are particular to different classes of analytes without having to make column or buffer changes or any other hardware configuration changes to the LC-MS system.Type: GrantFiled: March 12, 2020Date of Patent: May 17, 2022Assignee: Cohesive Technologies, Inc.Inventors: Joseph L. Herman, Robert Dewitte, Dayana Argoti
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Patent number: 10739321Abstract: A method of multiplexing the operation of a sample preparation and analysis system is disclosed. The system includes a sample preparation system capable of preparing a first sample in accordance with a first assay that is selected from a database containing a plurality of unique assays and preparing a second sample in accordance with a second, different assay. The method includes separately transporting the first and second prepared samples to an analysis station having first and second separation channels and an analyzer comprising a mass spectrometer. The method further includes simultaneously analyzing the first prepared sample with the analyzer in accordance with the first selected assay and separating the second prepared sample with the second separation channel in accordance with the second selected assay.Type: GrantFiled: August 30, 2018Date of Patent: August 11, 2020Assignee: THERMO FISHER SCIENTIFIC OYInventors: Robert DeWitte, Juhani Siidorov, Vesa Nuotio, Raimo Salminen, Jarmo Vehkomaki, Jukka Saukkonen, Bill Ostman, Joseph M. Senteno, John Edward Brann, III, Joseph L. Herman, Jeffrey A. Zonderman, Terry N. Olney
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Publication number: 20200209203Abstract: Systems, apparatuses, kits, and methods for purification and analysis of analytes having a broad range of hydrophobicities by liquid chromatography-mass spectrometry (LC-MS). Using one set of liquid chromatography columns, one set of mobile phase buffers, and, optionally, a single ionization method (e.g., electrospray ionization), a wide range of analytes can be purified and analyzed on a liquid chromatography-mass spectrometry (LC-MS) system. LC-MS purification and analysis of analytes having a broad range of partition coefficients is accomplished by selecting LC run parameters and MS system parameters that are particular to different classes of analytes without having to make column or buffer changes or any other hardware configuration changes to the LC-MS system.Type: ApplicationFiled: March 12, 2020Publication date: July 2, 2020Inventors: Joseph L. Herman, Robert Dewitte, Dayana Argoti
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Patent number: 10627374Abstract: Systems, apparatuses, kits, and methods for purification and analysis of analytes having a broad range of hydrophobicities by liquid chromatography-mass spectrometry (LC-MS). Using one set of liquid chromatography columns, one set of mobile phase buffers, and, optionally, a single ionization method (e.g., electrospray ionization), a wide range of analytes can be purified and analyzed on a liquid chromatography-mass spectrometry (LC-MS) system. LC-MS purification and analysis of analytes having a broad range of partition coefficients is accomplished by selecting LC run parameters and MS system parameters that are particular to different classes of analytes without having to make column or buffer changes or any other hardware configuration changes to the LC-MS system.Type: GrantFiled: February 28, 2017Date of Patent: April 21, 2020Assignee: Cohesive Technologies Inc.Inventors: Joseph L. Herman, Robert Dewitte, Dayana Argoti
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Patent number: 10557835Abstract: A sample preparation and analysis system. The system includes a sample preparation system and a sample analysis system. The sample preparation system prepares samples in accordance with an assay that is selected from a database containing a plurality of unique assays. The sample analysis system includes an analyzer that is dynamically reconfigurable based on the selected assay so as to analyze the prepared sample in accordance with that selected assay. A data communication link communicates data from the sample preparation system to the sample analysis system to reconfigure the analyzer in accordance with the selected assay.Type: GrantFiled: June 29, 2015Date of Patent: February 11, 2020Assignee: THERMO FISHER SCIENTIFIC OYInventors: Robert DeWitte, Juhani Siidorov, Vesa Nuotio, Raimo Salminen, Jarmo Vehkomaki, Jukka Saukkonen, Bill Ostman, Joseph M. Senteno, John Edward Brann, III, Joseph L. Herman, Jeffrey A. Zonderman, Terry N. Olney
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Publication number: 20180372697Abstract: A method of multiplexing the operation of a sample preparation and analysis system is disclosed. The system includes a sample preparation system capable of preparing a first sample in accordance with a first assay that is selected from a database containing a plurality of unique assays and preparing a second sample in accordance with a second, different assay. The method includes separately transporting the first and second prepared samples to an analysis station having first and second separation channels and an analyzer comprising a mass spectrometer. The method further includes simultaneously analyzing the first prepared sample with the analyzer in accordance with the first selected assay and separating the second prepared sample with the second separation channel in accordance with the second selected assay.Type: ApplicationFiled: August 30, 2018Publication date: December 27, 2018Inventors: Robert DeWitte, Juhani Siidorov, Vesa Nuotio, Raimo Salminen, Jarmo Vehkomaki, Jukka Saukkonen, Bill Ostman, Joseph M. Senteno, John Edward Brann, Joseph L. Herman, Jeffrey A. Zonderman, Terry N. Olney
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Patent number: 10088460Abstract: A sample preparation and analysis system. The system 10 includes a sample preparation system 12 and a sample analysis system 14. The sample preparation system 12 prepares samples in accordance with an assay that is selected from a database containing a plurality of unique assays. The sample analysis system 14 includes an analyzer 110 that is dynamically reconfigurable based on the selected assay so as to analyze the prepared sample in accordance with that selected assay. A data communication link 27 communicates data from the sample preparation system 12 to the sample analysis system 14 to reconfigure the analyzer 110 in accordance with the selected assay.Type: GrantFiled: October 28, 2011Date of Patent: October 2, 2018Assignee: THERMO FISHER SCIENTIFIC OYInventors: Robert DeWitte, Juhani Siidorov, Vesa Nuotio, Raimo Salminen, Jarmo Vehkomaki, Jukka Saukkonen, Bill Ostman, Joseph M. Senteno, John Edward Brann, III, Joseph L. Herman, Jeffrey A. Zonderman, Terry N. Olney
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Publication number: 20170168029Abstract: Systems, apparatuses, kits, and methods for purification and analysis of analytes having a broad range of hydrophobicities by liquid chromatography-mass spectrometry (LC-MS). Using one set of liquid chromatography columns, one set of mobile phase buffers, and, optionally, a single ionization method (e.g., electrospray ionization), a wide range of analytes can be purified and analyzed on a liquid chromatography-mass spectrometry (LC-MS) system. LC-MS purification and analysis of analytes having a broad range of partition coefficients is accomplished by selecting LC run parameters and MS system parameters that are particular to different classes of analytes without having to make column or buffer changes or any other hardware configuration changes to the LC-MS system.Type: ApplicationFiled: February 28, 2017Publication date: June 15, 2017Applicant: Cohesive Technologies Inc.Inventors: Joseph L. Herman, Robert Dewitte, Dayana Argoti
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Patent number: 9625429Abstract: Systems, apparatuses, kits, and methods for purification and analysis of analytes having a broad range of hydrophobicities by liquid chromatography-mass spectrometry (LC-MS). Using one set of liquid chromatography columns, one set of mobile phase buffers, and, optionally, a single ionization method (e.g., electrospray ionization), a wide range of analytes can be purified and analyzed on a liquid chromatography-mass spectrometry (LC-MS) system. LC-MS purification and analysis of analytes having a broad range of partition coefficients is accomplished by selecting LC run parameters and MS system parameters that are particular to different classes of analytes without having to make column or buffer changes or any other hardware configuration changes to the LC-MS system.Type: GrantFiled: October 28, 2011Date of Patent: April 18, 2017Assignee: Cohesive Technologies Inc.Inventors: Joseph L. Herman, Robert Dewitte, Dayana Argoti
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Publication number: 20170082585Abstract: A sample preparation and analysis system. The system 10 includes a sample preparation system 12 and a sample analysis system 14. The sample preparation system 12 prepares samples in accordance with an assay that is selected from a database containing a plurality of unique assays. The sample analysis system 14 includes an analyzer 110 that is dynamically reconfigurable based on the selected assay so as to analyze the prepared sample in accordance with that selected assay. A data communication link 27 communicates data from the sample preparation system 12 to the sample analysis system 14 to reconfigure the analyzer 110 in accordance with the selected assay.Type: ApplicationFiled: November 29, 2016Publication date: March 23, 2017Inventors: Robert DeWitte, Juhani Siidorov, Vesa Nuotio, Raimo Salminen, Jarmo Vehkomaki, Jukka Saukkonen, Bill Ostman, Joseph M. Senteno, John Edward Brann, III, Joseph L. Herman, Jeffrey A. Zonderman, Terry N. Olney
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Publication number: 20150301002Abstract: A sample preparation and analysis system. The system includes a sample preparation system and a sample analysis system. The sample preparation system prepares samples in accordance with an assay that is selected from a database containing a plurality of unique assays. The sample analysis system includes an analyzer that is dynamically reconfigurable based on the selected assay so as to analyze the prepared sample in accordance with that selected assay. A data communication link communicates data from the sample preparation system to the sample analysis system to reconfigure the analyzer in accordance with the selected assay.Type: ApplicationFiled: June 29, 2015Publication date: October 22, 2015Inventors: Robert DeWitte, Juhani Siidorov, Vesa Nuotio, Raimo Salminen, Jarmo Vehkomaki, Jukka Saukkonen, Bill Ostman, Joseph M. Senteno, John Edward Brann, III, Joseph L. Herman, Jeffrey A. Zonderman, Terry N. Olney
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Patent number: 9063159Abstract: Systems, kits, and methods for quantitation of metabolites of vitamin D by liquid chromatography-mass spectrometry (LC-MS). The systems, kits, and methods described herein stabilize and/or promote the formation of the protonated molecular ion ([M+H]+) for the vitamin D metabolites in the ionization source (e.g., electrospray ionization (“ESI”)). Formation of the molecular ion does not involve loss of a water molecule from the parent molecule. Subsequent fragmentation of the [M+H]+ ion yields product ions that are specific to each molecular ion. The systems, kits, and methods described herein provide for no compromise in specificity and provide for a significant increase in sensitivity relative to previously described methods.Type: GrantFiled: October 28, 2011Date of Patent: June 23, 2015Assignee: Cohesive Technologies Inc.Inventors: Joseph L. Herman, Dayana Argoti
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Publication number: 20140147878Abstract: Systems, kits, and methods for quantitation of metabolites of vitamin D by liquid chromatography-mass spectrometry (LC-MS). The systems, kits, and methods described herein stabilize and/or promote the formation of the protonated molecular ion ([M+H]+) for the vitamin D metabolites in the ionization source (e.g., electrospray ionization (“ESI”)). Formation of the molecular ion does not involve loss of a water molecule from the parent molecule. Subsequent fragmentation of the [M+H]+ ion yields product ions that are specific to each molecular ion. The systems, kits, and methods described herein provide for no compromise in specificity and provide for a significant increase in sensitivity relative to previously described methods.Type: ApplicationFiled: October 28, 2011Publication date: May 29, 2014Applicant: COHESIVE TECHNOLOGIES INC.Inventors: Joseph L. Herman, Dayana Argoti
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Publication number: 20140047906Abstract: Systems, apparatuses, kits, and methods for purification and analysis of analytes having a broad range of hydrophobicities by liquid chromatography-mass spectrometry (LC-MS). Using one set of liquid chromatography columns, one set of mobile phase buffers, and, optionally, a single ionization method (e.g., electrospray ionization), a wide range of analytes can be purified and analyzed on a liquid chromatography-mass spectrometry (LC-MS) system. LC-MS purification and analysis of analytes having a broad range of partition coefficients is accomplished by selecting LC run parameters and MS system parameters that are particular to different classes of analytes without having to make column or buffer changes or any other hardware configuration changes to the LC-MS system.Type: ApplicationFiled: October 28, 2011Publication date: February 20, 2014Applicant: COHESIVE TECHNOLOGIES INC.Inventors: Joseph L. Herman, Robert Dewitte, Dayana Argoti
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Publication number: 20130295597Abstract: A sample preparation and analysis system. The system 10 includes a sample preparation system 12 and a sample analysis system 14. The sample preparation system 12 prepares samples in accordance with an assay that is selected from a database containing a plurality of unique assays. The sample analysis system 14 includes an analyzer 110 that is dynamically reconfigurable based on the selected assay so as to analyze the prepared sample in accordance with that selected assay. A data communication link 115a communicates data from the sample preparation system 12 to the sample analysis system 14 to reconfigure the analyzer 110 in accordance with the selected assay.Type: ApplicationFiled: October 28, 2011Publication date: November 7, 2013Applicant: Thermo Fisher Scientific OyInventors: Robert DeWitte, Juhani Siidorov, Vesa Nuotio, Raimo Salminen, Jarmo Vehkomaki, Jukka Saukkonen, Bill Ostman, Joseph M. Senteno, John Edward Brann, III, Joseph L. Herman, Jeffrey A. Zonderman, Terry N. Olney
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Patent number: 6660729Abstract: A non-aqueous, particle-forming, fused pyrrolocarbazole-containing composition is disclosed. Upon contact with an aqueous medium, the particle-forming composition spontaneously disperses into suspended particles, thereby forming a stable suspension that provides greatly improved bioavailability of orally administered fused pyrrolocarbazole compounds.Type: GrantFiled: October 27, 2000Date of Patent: December 9, 2003Assignee: Cephalon, Inc.Inventors: David A. Dickason, Piyush R. Patel, Vincent Corvari, Efraim Shek, Joseph L. Herman, Jeffry M. Skell
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Patent number: 6200968Abstract: A non-aqueous, particle-forming, fused pyrrolocarbazole-containing composition is disclosed. Upon contact with an aqueous medium, the particle-forming composition spontaneously disperses into suspended particles, thereby forming a stable suspension that provides greatly improved bioavailability of orally administered fused pyrrolocarbazole compounds.Type: GrantFiled: August 5, 1999Date of Patent: March 13, 2001Assignee: Cephalon, Inc.Inventors: David A. Dickason, Piyush R. Patel, Vincent Corvari, Efraim Shek, Joseph L. Herman, Jeffry M. Skell
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Patent number: 5599808Abstract: Disclosed herein are aqueous indolocarbazole solutions. In one embodiment, the invention features a solution comprising: (1) an indolocarbazole; (ii) a selected organic solvent being present in a concentration of between about 1% and about 99% by weight inclusive, (iii) a dispersant being present in a concentration of between about 0.25% and about 10% by weight inclusive; (iv) water being present in a concentration of between 0% and about 99% by weight inclusive, and (v) a polyethylene glycol being present in a concentration of between 0% and about 60% by weight inclusive.Type: GrantFiled: February 3, 1995Date of Patent: February 4, 1997Assignee: Cephalon, Inc.Inventors: Joel D. Goldstein, Joseph L. Herman
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Patent number: 4191127Abstract: A method and apparatus for galvanizing galvanizable metal in a wire-like form. A descaled wire or the like is passed vertically and upwardly through a transversely flowing stream of molten zinc after which the so-coated wire or the like is either passed into a second processing zone or is passed through a shaping orifice, or both, as desired. The resulting so-processed wire is then cooled preferably by quenching in a flowing water bath.Type: GrantFiled: November 4, 1977Date of Patent: March 4, 1980Assignee: The Joseph L. Herman Family TrustInventor: Joseph L. Herman