Patents by Inventor Joseph L. Kim

Joseph L. Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex
    Publication number: 20020042046
    Abstract: The present invention relates to compositions and crystals of a hepatitis C virus protease in complex with its viral cofactor. This invention also relates to methods of using the structure coordinates of hepatitis C virus protease in complex with a synthetic NS4A to solve the structure of similar or homologous proteins or protein complexes.
    Type: Application
    Filed: September 14, 2001
    Publication date: April 11, 2002
    Applicant: Vertex Pharmaceuticals, Incorporated
    Inventors: Joseph L. Kim, Kurt A. Morgenstern, Chao Lin, Ted Fox, John A. Thomson
  • Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex
    Patent number: 6303287
    Abstract: The present invention relates to compositions and crystals of a hepatitis C virus protease in complex with its viral cofactor. This invention also relates to methods of using the structure coordinates of hepatitis C virus protease in complex with a synthetic NS4A to solve the structure of similar or homologous proteins or protein complexes.
    Type: Grant
    Filed: February 25, 1999
    Date of Patent: October 16, 2001
    Assignee: Vertex Pharmaceuticals, Incorporated
    Inventors: Joseph L. Kim, Kurt A. Morgenstern, Chao Lin, Ted Fox, John A. Thomson
  • Hepatitis C virus helicase crystals and coordinates that define helicase binding pockets
    Patent number: 6183121
    Abstract: The invention relates to the X-ray crystal structure of the hepatitis C virus helicase domain. More specifically, the invention relates to crystallized complexes of HCV helicase and an oligonucleotide, to crystallizable compositions of HCV helicase and an oligonucleotide and to methods of crystallizing an HCV helicase-oligonucleotide complex. The invention further relates to a computer programmed with the structure coordinates of the HCV helicase oligonucleotide binding pocket or the HCV helicase nucleotide triphosphate pocket wherein said computer is capable of displaying a three-dimensional representation of that binding pocket.
    Type: Grant
    Filed: August 3, 1998
    Date of Patent: February 6, 2001
    Assignee: Vertex Pharmaceuticals Inc.
    Inventors: Joseph L. Kim, Kurt A. Morgenstern, Paul R. Caron, Chao Lin
  • Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex
    Patent number: 6153579
    Abstract: The present invention relates to compositions and crystals of a hepatitis C virus protease in complex with its viral cofactor. This invention also relates to methods of using the structure coordinates of hepatitis C virus protease in complex with a synthetic NS4A to solve the structure of similar or homologous proteins or protein complexes.
    Type: Grant
    Filed: October 18, 1996
    Date of Patent: November 28, 2000
    Assignee: Vertex Pharmaceuticals, Incorporated
    Inventors: Joseph L. Kim, Kurt A. Morgenstern, Chao Lin, Ted Fox, John A. Thomson
  • Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them
    Patent number: 5978740
    Abstract: The present invention relates to crystallized molecules and molecular complexes which comprise the active site binding pocket or the FKBP12/FK506 binding pocket of calcineurin or close structural homologues to either binding pocket. This invention also relates to a data storage material encoded with the corresponding structure coordinates of those crystallized molecules or molecular complexes. Such data storage material is capable of displaying such molecules and molecular complexes as a graphical three-dimensional representation on a computer screen. In addition, this invention relates to methods of using the structure coordinates of those molecules or molecular complexes to solve the structure of homologous proteins. This invention also relates to methods of using the structure coordinates to screen and design compounds that bind to calcineurin or homologues thereof.
    Type: Grant
    Filed: August 9, 1995
    Date of Patent: November 2, 1999
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David M. Armistead, Matthew James Fitzgibbon, Mark Andrew Fleming, James P. Griffith, Eunice E. Kim, Joseph L. Kim, Michael D. Sintchak, John Allan Thomson, Keith P. Wilson