Abstract: De novo designed proteins with binding activity are disclosed, which were designed starting from a desired functional site and jointly filling in the missing sequence and structure needed to complete the protein, and uses of the binding proteins.

Abstract: In a circuit card assembly for use within an information processor (computer) wherein the assembly includes a fiber optic connector assembly as part thereof, there is provided means for enabling electrical connections to be made to the circuit card's circuitry in the same area as the fiber optic connector's housing so that charging of the card (to the potential of the mother board to which it will be coupled) can occur prior to coupling of the card to the board. Once the card is positioned and thus connected to the board, the charging means of the invention can be removed and a desired fiber optic connector inserted within the housing so that desired optical connections can be made with corresponding components (e.g., receiver, transmitter) which form part of the circuit card assembly. Both optical and electrical connections thus occur within the same housing.

Abstract: A rolling mill comprises a plurality of rolls, means for directing liquid coolant onto the rolls at the ingoing side of the mill and a casing or casings enclosing the directing means. The casing or casings have contact seals engaging the rolls to prevent unwanted egress of coolant onto work entering the mill. The means for directing coolant onto the rolls are mounted on one or more fixed backing supports and inflatable sealing means are arranged between the casing or casings and the fixed backing support or supports. The arrangement enables the position of the casing or casings to adjust dependent on the roll diameters.

Abstract: A rolling mill has a plurality of rolls, means to direct liquid coolant on to the rolls at the ingoing side of the mill mounted on backing supports and a casing or casings enclosing the directing means during operation. The casing or casings have contact seals engaging the rolls to prevent unwanted egress of coolant on to work entering the mill. Sealing means are provided between the casing or casings and the backing support or supports and the casing or casings can be withdrawn from the mill for maintenance purposes independently of said one or more backing supports.